Abstract
Antiparkinson therapy can be the primary cause of a range of nonmotor symptoms that include a set of complex disinhibitory psychomotor pathologies and are linked by their repetitive, reward or incentive-based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and encompass impulse control disorders (ICDs), punding, and the dopamine dysregulation syndrome (DDS). Common ICDs include pathological gambling, hypersexuality, compulsive eating, and compulsive buying. This review focuses on the phenomenology, epidemiology, and methods to identify and rate these disorders. The management of dopaminergic drug-related compulsive behaviors is discussed in the light of the current understanding of the neurobiological substrate of these disorders.
2009 Movement Disorder Society.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antiparkinson Agents / adverse effects*
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Antiparkinson Agents / therapeutic use
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Compulsive Behavior / chemically induced*
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Compulsive Behavior / epidemiology
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Compulsive Behavior / physiopathology
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Deep Brain Stimulation
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Disease Susceptibility
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Dopamine / physiology
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Dopamine Agonists / adverse effects*
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Dopamine Agonists / therapeutic use
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Female
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Gambling
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Humans
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Impulsive Behavior / chemically induced*
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Impulsive Behavior / epidemiology
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Impulsive Behavior / physiopathology
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Limbic System / drug effects
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Limbic System / physiopathology
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Male
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Parkinson Disease / drug therapy
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Parkinson Disease / psychology*
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Prevalence
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Reward
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Sexual Behavior / drug effects
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Stereotyped Behavior / drug effects
Substances
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Antiparkinson Agents
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Dopamine Agonists
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Dopamine