Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine

Joyce L W Yau; June Noble; Karen E Chapman; Jonathan R Seckl

doi:10.1016/j.molbrainres.2004.06.033

Differential regulation of variant glucocorticoid receptor mRNAs in the rat hippocampus by the antidepressant fluoxetine

Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):189-92. doi: 10.1016/j.molbrainres.2004.06.033.

Authors

Joyce L W Yau¹, June Noble, Karen E Chapman, Jonathan R Seckl

Affiliation

¹ Endocrinology Unit, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK. Joyce.Yau@ed.ac.uk

PMID: 15469896
DOI: 10.1016/j.molbrainres.2004.06.033

Abstract

Adult rats were given antidepressant drugs orally. Fluoxetine, but not moclobemide, venlafaxine, tianeptine or desipramine, increased total glucocorticoid receptor (GR) mRNA in the hippocampus after 4 weeks. Further examination revealed that GR mRNA containing the brain-specific exon 1(7) was increased across all hippocampal subregions. In contrast, expression of the major exon 1(10) and another brain-specific exon 1(5)-containing GR mRNAs were unchanged. Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antidepressive Agents, Second-Generation / administration & dosage
Antidepressive Agents, Second-Generation / pharmacology*
Brain / anatomy & histology
Brain / metabolism
Exons
Fluoxetine / administration & dosage
Fluoxetine / pharmacology*
Gene Expression Regulation
Hippocampus* / drug effects
Hippocampus* / metabolism
Protein Isoforms / genetics
Protein Isoforms / metabolism*
RNA, Messenger / metabolism*
Rats
Receptors, Glucocorticoid / genetics
Receptors, Glucocorticoid / metabolism*

Substances

Antidepressive Agents, Second-Generation
Protein Isoforms
RNA, Messenger
Receptors, Glucocorticoid
Fluoxetine