Format

Send to:

Choose Destination
See comment in PubMed Commons below
JAMA. 2004 Jul 7;292(1):81-5.

Endometrial cells derived from donor stem cells in bone marrow transplant recipients.

Author information

  • 1Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Conn 06520-8063, USA. hugh.taylor@yale.edu

Abstract

CONTEXT:

Regeneration of the endometrium in each menstrual cycle is required for reproduction. Endogenous endometrial stem cells reside in the basalis layer and serve as a source of cells that differentiate to form the endometrium. Bone marrow-derived cells have been shown to take on functions outside the hematopoietic system.

OBJECTIVE:

To investigate the possibility that cells of extrauterine origin could repopulate the endometrium.

DESIGN, SETTING, AND PATIENTS:

Endometrium from 4 HLA-mismatched bone marrow transplant recipients (1998-2002) was evaluated for donor HLA expression. Each recipient had a bone marrow donor with an HLA type that enabled determination of the origin of any cell. Endometrial biopsies also were obtained from 4 healthy control women.

MAIN OUTCOME MEASURE:

HLA type was determined by immunohistochemistry and by reverse transcription-polymerase chain reaction.

RESULTS:

Donor-derived endometrial cells were detected in endometrial biopsy samples from all bone marrow recipients and accounted for 0.2% to 48% of epithelial cells and 0.3% to 52% of stromal cells. None of the controls demonstrated HLA mismatch in endometrial samples.

CONCLUSION:

These findings demonstrate that endometrial cells can originate from donor-derived bone marrow cells and suggest that nonuterine stem cells contribute to the regeneration of endometrial tissue.

PMID:
15238594
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk