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Science. 2004 Jul 2;305(5680):90-3.

Lack of a fusion requirement for development of bone marrow-derived epithelia.

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  • 1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Analysis of developmental plasticity of bone marrow-derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs without cell-cell fusion. We use the Cre/lox system together with beta-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion.

PMID:
15232107
[PubMed - indexed for MEDLINE]
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