Migraine aura: a knockin mouse with a knockout message

Neuron. 2004 Mar 4;41(5):679-80. doi: 10.1016/s0896-6273(04)00112-6.

Abstract

Migraine aura is a sometimes disabling disorder of the brain that involves significant neurological symptoms in about 30% of patients. In this issue of Neuron, van den Maagdenberg et al. characterize a mouse with a knockin mutation known to cause familial hemiplegic migraine and provide evidence that a lowered threshold to the triggering of CSD may account for the devastating phenotype of familial hemiplegic migraine.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Humans
  • Mice
  • Mice, Knockout
  • Migraine with Aura / genetics*
  • Mutation*