Effects of doxasozine and atenolol on hemodynamics and myocardial ischemia were studied in 20 males (mean age 52.5 +/- 5.3 years) who had survived macrofocal myocardial infarction associated with arterial hypertension stage I-II. The treatment efficacy was assessed clinically, by functional and radionuclide tests. A new long-acting alpha 1-adrenoblocker doxasozine was given in a mean dose 4-8 mg/day. A course of this treatment lowered systolic arterial pressure by 8.3% and diastolic one by 8.1%. As all the patients developed sinus tachycardia on day 5-10 of doxasozine treatment, the patients received additionally beta 1-adrenoblocker atenolol (12.5-25 mg/day) which adequately controlled heart rate. The combined therapy reduced frequency and severity of angina by 34.7%, 24-h need in nitroglycerine by 37.9%, exercise tolerance--by 18.4% as well as improved myocardial perfusion. Patients with concomitant benign prostatic hyperplasia showed attenuation of disuric disorders. Side effects (vertigo, anxiety) occurred in 3 cases (15%), but were not severe enough to demand the treatment discontinuation.