Coronary artery disease and the MEF2A transcription factor

Sci Aging Knowledge Environ. 2003 Dec 3;2003(48):pe33. doi: 10.1126/sageke.2003.48.pe33.

Abstract

Coronary artery disease (CAD) that results from lesions of the vascular wall is a major cause of myocardial infarction (MI) and stroke. A human pedigree with a predisposition to CAD and MI has been shown to harbor a mutation in the MEF2A transcription factor. These findings reveal a new function for this regulator of cardiovascular development and raise intriguing questions about the underlying mechanisms of CAD.

Publication types

  • Review

MeSH terms

  • Coronary Artery Disease / genetics*
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology
  • Humans
  • MADS Domain Proteins
  • MEF2 Transcription Factors
  • Mutation
  • Myogenic Regulatory Factors
  • Transcription Factors / genetics*
  • Transcription Factors / physiology

Substances

  • DNA-Binding Proteins
  • MADS Domain Proteins
  • MEF2 Transcription Factors
  • MEF2A protein, human
  • Myogenic Regulatory Factors
  • Transcription Factors