Abstract
Coronary artery disease (CAD) that results from lesions of the vascular wall is a major cause of myocardial infarction (MI) and stroke. A human pedigree with a predisposition to CAD and MI has been shown to harbor a mutation in the MEF2A transcription factor. These findings reveal a new function for this regulator of cardiovascular development and raise intriguing questions about the underlying mechanisms of CAD.
MeSH terms
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Coronary Artery Disease / genetics*
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / physiology
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Humans
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MADS Domain Proteins
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MEF2 Transcription Factors
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Mutation
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Myogenic Regulatory Factors
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Transcription Factors / genetics*
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Transcription Factors / physiology
Substances
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DNA-Binding Proteins
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MADS Domain Proteins
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MEF2 Transcription Factors
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MEF2A protein, human
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Myogenic Regulatory Factors
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Transcription Factors