Antinociceptive effects of supraspinal rat cart (55-102) peptide in mice

Brain Res. 2003 Sep 5;983(1-2):233-6. doi: 10.1016/s0006-8993(03)03094-4.

Abstract

We investigated the effects of rat cocaine- and amphetamine-regulated transcript CART (55-102) after i.c.v. administration in mouse models of acute and persistent pain. CART was not active in the tail-flick or PPQ tests. It increased the latency to paw licking in the hot-plate test but only at doses that impaired motor function. CART produces antinociception in the formalin test in both phases. Our results suggest that CART is involved in supraspinal pain transmission.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analgesics*
  • Animals
  • Dose-Response Relationship, Drug
  • Formaldehyde
  • Hot Temperature
  • Injections, Intraventricular
  • Mice
  • Mice, Inbred ICR
  • Nerve Tissue Proteins
  • Pain Measurement / drug effects
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / pharmacology*
  • Postural Balance / drug effects
  • Rats
  • Reaction Time / drug effects

Substances

  • Analgesics
  • Nerve Tissue Proteins
  • Peptide Fragments
  • cocaine- and amphetamine-regulated transcript protein (55-102)
  • Formaldehyde