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Neuron. 2003 Jan 9;37(1):11-4.

Diversifying neural cells through order of birth and asymmetry of division.

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  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.


A key question in developmental neurobiology is how the diversity of cell types that make up the mature nervous system are generated from a common set of progenitor cells. Drosophila genes governing temporal cell fate determination and asymmetric cell divisions involving numb may represent evolutionarily conserved mechanisms for regulating cell fate diversification in the developing nervous system.

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