Abstract
In this issue of Cancer Cell, propose a single chromosomal translocation as the cause of a particularly troubling form of breast cancer, secretory carcinoma. They challenge widely held beliefs concerning breast carcinogenesis as well as beliefs concerning the absolute association of specific fusion genes with specific tumor types. Their data highlight the role of Trk signaling in breast cancer and also suggest a target for drug development.
Publication types
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Comment
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Comparative Study
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Review
MeSH terms
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Artificial Gene Fusion*
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Carcinoma, Ductal, Breast / genetics*
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Carcinoma, Ductal, Breast / metabolism
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Carcinoma, Ductal, Breast / pathology
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Child
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DNA, Recombinant / metabolism*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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ETS Translocation Variant 6 Protein
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Humans
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Protein Structure, Tertiary
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Proto-Oncogene Proteins c-ets
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Receptor, trkC / genetics
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Receptor, trkC / metabolism*
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Recombinant Fusion Proteins / metabolism*
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Repressor Proteins / chemistry
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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Retroviridae / genetics
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Transduction, Genetic
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Translocation, Genetic
Substances
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DNA, Recombinant
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DNA-Binding Proteins
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Proto-Oncogene Proteins c-ets
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RNA, Messenger
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Recombinant Fusion Proteins
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Repressor Proteins
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Receptor, trkC