This paper discusses application of the model of human occupation to the worker with an injury or disability. Concepts from the model of human occupation (MOHO) are used to frame potential work-related strengths and weaknesses. Using MOHO as a framework to understand the worker with an injury or disability provides a more complete and holistic understanding of the many factors which can affect a worker. In particular, the model illuminates how factors of capacity, motivation, lifestyle, and environment inter-relate in determining a worker's success or failure. Implications for using the model to achieve a more effective work-related practice are discussed.