Hemicrania continua responds to cyclooxygenase-2 inhibitors

Headache. 2002 Jun;42(6):530-1. doi: 10.1046/j.1526-4610.2002.02131.x.

Abstract

Background: Hemicrania continua is a primary headache disorder defined by its absolute responsiveness to indomethacin. We report the treatment response to two cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, in a series of patients with hemicrania continua.

Methods: Fourteen patients were treated, 9 with rofecoxib and 5 with celecoxib.

Results: Three patients in each group had a complete response to treatment.

Conclusion: The cyclooxygenase-2 inhibitors may represent an alternative to indomethacin in the treatment of hemicrania continua. Their mechanism of action for this potential indication is unknown.

MeSH terms

  • Celecoxib
  • Cyclooxygenase Inhibitors / therapeutic use*
  • Female
  • Humans
  • Indomethacin / therapeutic use
  • Lactones / therapeutic use*
  • Male
  • Migraine Disorders / drug therapy*
  • Pyrazoles
  • Recurrence
  • Sulfonamides / therapeutic use*
  • Sulfones

Substances

  • Cyclooxygenase Inhibitors
  • Lactones
  • Pyrazoles
  • Sulfonamides
  • Sulfones
  • rofecoxib
  • Celecoxib
  • Indomethacin