Combined factor V and VIII deficiency in Indian population

S Shetty; M Madkaikar; S Nair; A Pawar; S Baindur; A Pathare; K Ghosh; D Mohanty

doi:10.1046/j.1365-2516.2000.00421.x

Combined factor V and VIII deficiency in Indian population

Haemophilia. 2000 Sep;6(5):504-7. doi: 10.1046/j.1365-2516.2000.00421.x.

Authors

S Shetty¹, M Madkaikar, S Nair, A Pawar, S Baindur, A Pathare, K Ghosh, D Mohanty

Affiliation

¹ Institute of Immunohaematology (ICMR), 13th floor, New Multistoreyed Bldg, KEM Hospital campus, Parel Mumbai-400012, Mumbai.

PMID: 11012693
DOI: 10.1046/j.1365-2516.2000.00421.x

Abstract

The clinical and haematological heterogeneity in cases of the rare combined factor V and VIII deficiency has not been reported so far from India. Nine such cases belonging to five unrelated families have been analysed in the present study for the various haematological and clinical parameters. A very mild clinical presentation is seen in all these cases. The clinical manifestations, however, do not correlate with the plasma levels of these factors.

MeSH terms

Adolescent
Adult
Blood Coagulation Factor Inhibitors / metabolism
Blood Coagulation Tests
Child
Factor V / metabolism
Factor V Deficiency / blood
Factor V Deficiency / complications*
Factor VIII / metabolism
Family Health
Female
Hemophilia A / blood
Hemophilia A / complications*
Hemorrhage / etiology
Humans
India
Male
Middle Aged
Pregnancy
von Willebrand Factor / metabolism

Substances

Blood Coagulation Factor Inhibitors
factor V Leiden
von Willebrand Factor
Factor V
Factor VIII