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Curr Opin Cell Biol. 1999 Oct;11(5):567-72.

Controversies at the cytoplasmic face of the cadherin-based adhesion complex.

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  • 1Department of Pathology Yale University School of Medicine 310 Cedar Street, New Haven, CT 06510, USA.


Cadherin-mediated cell-cell interactions are modulated by protein interactions at the cytoplasmic face of the membrane. Recent work has shown that phosphorylation of both p120(ctn) and beta-catenin affects their interaction with cadherins and the molecular connections to the cytoskeleton. The cytoskeletal connections most probably include interactions between alpha-catenin, and/or alpha-actinin, vinculin, ZO-1, actin and possibly spectrin.

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