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Immunology. 1999 Jun;97(2):188-96.

Do self-perpetuating B lymphocytes drive human autoimmune disease?

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  • 1Centre for Rheumatology, Department of Medicine, University College London, UK.

Abstract

Normal immunological memory is thought to be underpinned by T lymphocytes. However, in rheumatoid arthritis there are indications that T-lymphocyte control has been subverted by self-perpetuating B lymphocytes. Potential mechanisms in other autoimmune states are less clear, but a number of observations suggest that misappropriation of immunological memory by B lymphocytes may be a common feature of human autoantibody-associated disease. Put simply, autoantibodies drive their own production. If so, the availability of safe B-lymphocyte-depleting agents provides a potential means for reversal of autoimmunity.

PMID:
10447731
[PubMed - indexed for MEDLINE]
PMCID:
PMC2326840
Free PMC Article
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