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The following terms were not found in PubMed: -3-nitro-2H-pyrrol-2-ylidene
Page 1
Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice.
Zhang YQ, Min HK, Hong E, Yu E, Gu SM, Yoon SS, Lee D, Lee J, Hong JT, Yun J. Zhang YQ, et al. Biomed Pharmacother. 2023 Dec 31;169:115860. doi: 10.1016/j.biopha.2023.115860. Epub 2023 Nov 9. Biomed Pharmacother. 2023. PMID: 37948992 Free article.
Here, we used the ICSS model to evaluate the abuse potential of 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; dextroamphetamine; alpha-Pyrrolidinobutyrophenone (alpha-PBT); 4'-Fluoro-4-methylaminorex (4-FPO); methamphetamine; larocaine; phentermine; p …
Here, we used the ICSS model to evaluate the abuse potential of 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; d …
Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Horton DB, et al. J Pharmacol Exp Ther. 2011 Oct;339(1):286-97. doi: 10.1124/jpet.111.184770. Epub 2011 Jul 21. J Pharmacol Exp Ther. 2011. PMID: 21778282 Free PMC article.
The aim of the current study was to determine the pharmacological effect of replacement of the N-methyl moiety with a chiral N-1,2-dihydroxypropyl (N-1,2-diol) moiety, which enhances water solubility, altering the configuration of the N-1,2-diol moiety …
The aim of the current study was to determine the pharmacological effect of replacement of the N-methyl moiety with a chiral N-1 …
The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine.
Ferreira RCM, Castor MGM, Piscitelli F, Di Marzo V, Duarte IDG, Romero TRL. Ferreira RCM, et al. J Pain. 2018 May;19(5):487-495. doi: 10.1016/j.jpain.2017.12.002. Epub 2017 Dec 13. J Pain. 2018. PMID: 29247851 Free article.
The tissue levels of anandamide (AEA), 2-arachidonoylglycerol, palmitoylethanolamide, and oleoylethanolamide were measured using liquid chromatography coupled to single quadrupole mass spectrometry. The administration of the cannabinoid receptor type 1 (CB(1)) antag …
The tissue levels of anandamide (AEA), 2-arachidonoylglycerol, palmitoylethanolamide, and oleoylethanolamide were measured using liquid chro …
Synthesis of N-substituted 3-(2-aryl-2-oxoethyl)-3-hydroxyindolin-2-ones and their conversion to N-substituted (E)-3-(2-aryl-2-oxoethylidene)indolin-2-ones: synthetic sequence, spectroscopic characterization and structures of four 3-hydroxy compounds and five oxoethylidene products.
Becerra D, Castillo J, Insuasty B, Cobo J, Glidewell C. Becerra D, et al. Acta Crystallogr C Struct Chem. 2020 May 1;76(Pt 5):433-445. doi: 10.1107/S2053229620004143. Epub 2020 Apr 20. Acta Crystallogr C Struct Chem. 2020. PMID: 32367824 Free PMC article.
In each of (RS)-1-benzyl-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]indolin-2-one, C(24)H(21)NO(4), (Ic), and (RS)-1-benzyl-3-{2-[4-(dimethylamino)phenyl]-2-oxoethyl}-3-hydroxyindolin-2-one, C(25)H(24)N(2)O(3), (Id), inversion-related pairs of molecul …
In each of (RS)-1-benzyl-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]indolin-2-one, C(24)H(21)NO(4), (Ic), and (RS)- …
New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders.
Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP. Lee NR, et al. AAPS J. 2018 Feb 9;20(2):29. doi: 10.1208/s12248-018-0192-y. AAPS J. 2018. PMID: 29427069 Free PMC article.
Lobelane inhibited neurochemical and behavioral effects of methamphetamine, but tolerance developed to its behavioral efficacy in reducing methamphetamine self-administration, preventing further development. The lobelane analog, R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-meth …
Lobelane inhibited neurochemical and behavioral effects of methamphetamine, but tolerance developed to its behavioral efficacy in reducing m …
Synthesis and study on analgesic effects of 1-[1-(4-methylphenyl) (cyclohexyl)] 4-piperidinol and 1-[1-(4-methoxyphenyl) (cyclohexyl)] 4-piperidinol as two new phencyclidine derivatives.
Ahmadi A, Khalili M, Abbassi S, Javadi M, Mahmoudi A, Hajikhani R. Ahmadi A, et al. Arzneimittelforschung. 2009;59(4):202-6. doi: 10.1055/s-0031-1296386. Arzneimittelforschung. 2009. PMID: 19517897
Phencyclidine (1-(1-phenylcyclohexyl) piperidine; CAS 956-90-1; PCP, I) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties have been studied. In this work, new methyl and methoxy hydroxyl d …
Phencyclidine (1-(1-phenylcyclohexyl) piperidine; CAS 956-90-1; PCP, I) has shown analgesic effects. Some of its …
Design, Synthesis, and Anti-Cervical Cancer and Reversal of Tumor Multidrug Resistance Activity of Novel Nitrogen-Containing Heterocyclic Chalcone Derivatives.
Yang Z, Liu ZY, Ablise M, Maimaiti A, Mutalipu Z, Alimujiang Y, Aihaiti A. Yang Z, et al. Molecules. 2023 Jun 3;28(11):4537. doi: 10.3390/molecules28114537. Molecules. 2023. PMID: 37299013 Free PMC article.
Following preliminary conformational analysis, compound 6f ((E)-1-(2-hydroxy-5-((4-hydroxypiperidin-1-yl)methyl)-4-methoxyphenyl)-3-(4-((4-methylpiperidin-1-yl)methyl)phenyl)prop-2-en-1-one) exhibited significant antiprolife …
Following preliminary conformational analysis, compound 6f ((E)-1-(2-hydroxy-5-((4-hydroxypiperidin-1-yl)methyl)-4 …
The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.
Jiang SK, Zhang M, Tian ZL, Wang M, Zhao R, Wang LL, Li SS, Liu M, Li JY, Zhang MZ, Guan DW. Jiang SK, et al. Eur J Pharmacol. 2015 Aug 15;761:1-10. doi: 10.1016/j.ejphar.2015.04.018. Epub 2015 Apr 23. Eur J Pharmacol. 2015. PMID: 25912803
The monoacylglycerol lipase (MAGL) inhibitor (4-nitrophenyl)4-[bis(1,3-benzodioxol -5-yl)-hydroxymethyl]piperidine-1-carboxylate (JZL184) has been previously reported to reduce inflammation in colitis and acute lung injury in mice, which provide a new strateg …
The monoacylglycerol lipase (MAGL) inhibitor (4-nitrophenyl)4-[bis(1,3-benzodioxol -5-yl)-hydroxymethyl]piperidine-1-ca …
The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.
Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L. Roth BL, et al. PLoS One. 2013;8(3):e59334. doi: 10.1371/journal.pone.0059334. Epub 2013 Mar 19. PLoS One. 2013. PMID: 23527166 Free PMC article.
The ketamine analogues methoxetamine ((RS)-2-(ethylamino)-2-(3-methoxyphenyl)cyclohexanone) and 3-MeO-PCE (N-ethyl-1-(3-methoxyphenyl)cyclohexanamine) and the 3- and 4-methoxy analogues of phencyclidine, (1-[1-(3-methoxyphenyl)cyclohexyl]piperidine and …
The ketamine analogues methoxetamine ((RS)-2-(ethylamino)-2-(3-methoxyphenyl)cyclohexanone) and 3-MeO-PCE (N-ethyl-1-(3-methoxyphenyl …
18 results