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(1,3-Dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones. A series of novel central nervous system depressants.
Butler DE, Wise LD, DeWald HA. Butler DE, et al. J Med Chem. 1984 Nov;27(11):1396-400. doi: 10.1021/jm00377a003. J Med Chem. 1984. PMID: 6492070
A series of novel (1,3-dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones was synthesized. ...This report focuses on the synthesis and structure-activity relationships of these compounds. (5-Amino-1-ethyl-3-methyl-1H-pyrazol-4-yl)(2-chlorophenyl) methanone (21) was the …
A series of novel (1,3-dialkyl-5-amino-1H-pyrazol-4-yl)arylmethanones was synthesized. ...This report focuses on the synthesis and st …
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
Andersen KE, Lau J, Lundt BF, Petersen H, Huusfeldt PO, Suzdak PD, Swedberg MD. Andersen KE, et al. Bioorg Med Chem. 2001 Nov;9(11):2773-85. doi: 10.1016/s0968-0896(01)00148-1. Bioorg Med Chem. 2001. PMID: 11597457
In a previous series of potent GABA uptake inhibitors published from this laboratory, we noticed that asymmetry in the substitution pattern of the bis-aromatic moiety in known GABA uptake inhibitors such as 4 [1-(4,4-diphenyl-3-butenyl)-3-piperidinecarboxylic acid] and 5 [ …
In a previous series of potent GABA uptake inhibitors published from this laboratory, we noticed that asymmetry in the substitution pattern …