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N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta.
J Pharmacol Exp Ther. 2006 Jul;318(1):124-31. doi: 10.1124/jpet.106.101477. Epub 2006 Apr 12.
J Pharmacol Exp Ther. 2006.
PMID: 16611852
We hypothesized that IB-MECA may protect the heart at reperfusion by preventing the opening of mitochondrial permeability transition pore (mPTP) through inactivation of glycogen synthase kinase (GSK) 3beta. IB-MECA (1 microM) applied during reperfusion reduced infarct size …
We hypothesized that IB-MECA may protect the heart at reperfusion by preventing the opening of mitochondrial permeability transition pore (m …
Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways.
Zhu H, Liu X, Wang X, Li Y, Ma F, Tan B, Zhou P, Fu F, Su R.
Zhu H, et al.
Eur J Pharmacol. 2023 Oct 15;957:176038. doi: 10.1016/j.ejphar.2023.176038. Epub 2023 Aug 30.
Eur J Pharmacol. 2023.
PMID: 37657742
MAIN METHODS: The effects of the Gbetagamma inhibitor 3',4',5',6'-tetrahydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one (gallein) and antagonistic peptide betaARKct (beta-adrenergic receptor kinase C-terminal fragment) on DOM-induced HTR were studied via an HTR test. ...More …
MAIN METHODS: The effects of the Gbetagamma inhibitor 3',4',5',6'-tetrahydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one (gallein) and a …
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