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The effect of e-, i-, and n-nitric oxide synthase inhibition on colonic motility in normal and muscular dystrophy (mdx) mice.
Tameyasu T, Ogura S, Ogihara K. Tameyasu T, et al. Jpn J Physiol. 2004 Dec;54(6):555-66. doi: 10.2170/jjphysiol.54.555. Jpn J Physiol. 2004. PMID: 15760488 Free article.
The frequency of migrating motor complexes (MMC) was higher in the proximal than in the distal segments in mdx colon (0.56 vs. 0.25 cpm) and in the control colon (0.7 vs. 0.25 cpm), and there was no difference when mdx was compared to control segments. High concentrations of NOS …
The frequency of migrating motor complexes (MMC) was higher in the proximal than in the distal segments in mdx colon (0.56 vs. 0.25 cpm) and …
Involvement of calcium/calmodulin-dependent protein kinase II to endotoxin-induced vascular hyporeactivity in rat superior mesenteric artery.
Ozveren E, Korkmaz B, Buharalioglu CK, Tunctan B. Ozveren E, et al. Pharmacol Res. 2006 Sep;54(3):208-18. doi: 10.1016/j.phrs.2006.05.001. Epub 2006 May 12. Pharmacol Res. 2006. PMID: 16777431
Incubation with endotoxin (100 microg ml(-1)) for 4h caused vascular hyporeactivity to norepinephrine which was completely abolished by phenylene-1,3-bis[ethane-2-isothiourea] dihydrobromide (1,3-PBIT), a selective iNOS inhibitor, methyl arachidonyl fl …
Incubation with endotoxin (100 microg ml(-1)) for 4h caused vascular hyporeactivity to norepinephrine which was completely abolished by phen …
Inhibition of extracellular signal-regulated kinase (ERK1/2) activity reverses endotoxin-induced hypotension via decreased nitric oxide production in rats.
Tunctan B, Korkmaz B, Dogruer ZN, Tamer L, Atik U, Buharalioglu CK. Tunctan B, et al. Pharmacol Res. 2007 Jul;56(1):56-64. doi: 10.1016/j.phrs.2007.03.006. Epub 2007 Apr 13. Pharmacol Res. 2007. PMID: 17524662
Selective inhibition of iNOS with phenylene-1,3-bis[ethane-2-isothiourea] dihydrobromide (1,3-PBIT) (10 mg kg(-1), i.p.; 1h after endotoxin) did not change the endotoxin-induced increase in ERK1/2 activity. ...
Selective inhibition of iNOS with phenylene-1,3-bis[ethane-2-isothiourea] dihydrobromide (1,3-PBIT) (10 mg kg(-1 …
Extracellular signal-regulated kinase (ERK1/2) contributes to endotoxin-induced hyporeactivity via nitric oxide and prostacyclin production in rat aorta.
Korkmaz B, Ozveren E, Buharalioglu CK, Tunctan B. Korkmaz B, et al. Pharmacology. 2006;78(3):123-8. doi: 10.1159/000095962. Epub 2006 Sep 27. Pharmacology. 2006. PMID: 17008773
The endotoxin-induced increase in the EC(50) value of norepinephrine was decreased by phenylene-1,3-bis[ethane-2-isothiourea] dihydrobromide (1,3-PBIT), a selective inducible NO synthase inhibitor, and U0126, a selective inhibitor of ERK1/2 phosphoryla …
The endotoxin-induced increase in the EC(50) value of norepinephrine was decreased by phenylene-1,3-bis[ethane-2-isothiourea] dihydrobrom …
Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU. Tunctan B, et al. Nitric Oxide. 2013 Sep 1;33:18-41. doi: 10.1016/j.niox.2013.05.001. Epub 2013 May 14. Nitric Oxide. 2013. PMID: 23684565 Free PMC article.