Sexual differentiation of the central nervous system

Science. 1981 Mar 20;211(4488):1294-302. doi: 10.1126/science.6163211.

Abstract

Sexual differentiation of reproductive and behavior patterns is largely effected by hormones produced by the gonads. In many higher vertebrates, an integral part of this process is the induction of permanent and essentially irreversible sex differences in central nervous function, in response to gonadal hormones secreted early in development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Androgens / metabolism
  • Androgens / physiology
  • Animals
  • Birds / physiology
  • Brain / metabolism
  • Central Nervous System / embryology*
  • Central Nervous System / physiology
  • Estrogens / physiology
  • Female
  • Humans
  • Male
  • Mammals / physiology
  • Morphogenesis
  • Ovary / metabolism
  • Receptors, Cell Surface / metabolism
  • Receptors, Steroid / metabolism
  • Sex Characteristics
  • Sex Determination Analysis
  • Sex Differentiation*
  • Testis / metabolism
  • Time Factors
  • alpha-Fetoproteins / physiology

Substances

  • Androgens
  • Estrogens
  • Receptors, Cell Surface
  • Receptors, Steroid
  • alpha-Fetoproteins