Acute vs. chronic EEG effects in maprotiline- and in clomipramine-treated depressive inpatients and the prediction of therapeutic outcome

G Ulrich; H J Haug; E Fähndrich

doi:10.1016/0165-0327(94)90020-5

Acute vs. chronic EEG effects in maprotiline- and in clomipramine-treated depressive inpatients and the prediction of therapeutic outcome

J Affect Disord. 1994 Nov;32(3):213-7. doi: 10.1016/0165-0327(94)90020-5.

Authors

G Ulrich¹, H J Haug, E Fähndrich

Affiliation

¹ Psychiatrische Klinik und Poliklinik, Freie Universität Berlin, Germany.

PMID: 7852663
DOI: 10.1016/0165-0327(94)90020-5

Abstract

Patients treated with the norepinephrine uptake inhibitor maprotiline showed an opposite tendency between acute and chronic effect of EEG. Whereas the acute effect indicated a decrease upon EEG vigilance, the chronic effect indicated an increase. Under clomipramine which acts upon different transmitter systems in a complex, up to now not fully understood way, acute and chronic EEG effects could not be differentiated.

MeSH terms

Adult
Aged
Clomipramine / administration & dosage
Clomipramine / pharmacology*
Clomipramine / therapeutic use*
Depressive Disorder / diagnosis
Depressive Disorder / drug therapy*
Dose-Response Relationship, Drug
Electroencephalography / drug effects*
Female
Humans
Male
Maprotiline / administration & dosage
Maprotiline / pharmacology*
Maprotiline / therapeutic use*
Middle Aged
Treatment Outcome

Substances

Maprotiline
Clomipramine