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Toxicogenomics in drug discovery and development -- making an impact.

Wills Q, Mitchell C.

Altern Lab Anim. 2009 Sep;37 Suppl 1:33-7.PMID: 19807202 [PubMed - in process]Related articles

The Potential of Embryonic Stem Cells Combined with -Omics Technologies as Model Systems for Toxicology.

Winkler J, Sotiriadou I, Chen S, Hescheler J, Sachinidis A.

Curr Med Chem. 2009 Nov 17. [Epub ahead of print]PMID: 19929785 [PubMed - as supplied by publisher]Related articles

Carbon tetrachloride affects inflammation-related biochemical networks in the mouse liver as identified by a customized cDNA microarray system.

Inadera H, Tachibana S, Suzuki A, Shimomura A.

Environ Health Prev Med. 2009 Nov 13. [Epub ahead of print]PMID: 19911120 [PubMed - as supplied by publisher]Related articles

STITCH 2: an interaction network database for small molecules and proteins.

Kuhn M, Szklarczyk D, Franceschini A, Campillos M, von Mering C, Jensen LJ, Beyer A, Bork P.

Nucleic Acids Res. 2009 Nov 6. [Epub ahead of print]PMID: 19897548 [PubMed - as supplied by publisher]Related articlesFree article

Characterization of Peroxisome Proliferator-Activated Receptor {alpha} (PPAR{alpha}) - Independent Effects of PPAR{alpha} Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate Also Activates the Constitutive Activated Receptor.

Ren H, Aleksunes LM, Wood C, Vallanat B, George MH, Klaassen CD, Corton JC.

Toxicol Sci. 2009 Oct 22. [Epub ahead of print]PMID: 19850644 [PubMed - as supplied by publisher]Related articles

Environmental toxicogenomics: A post-genomic approach to analysing biological responses to environmental toxins.

Jayapal M, Bhattacharjee RN, Melendez AJ, Hande MP.

Int J Biochem Cell Biol. 2009 Oct 29. [Epub ahead of print]PMID: 19836462 [PubMed - as supplied by publisher]Related articles

Causality assessment in drug-induced liver injury.

Hayashi PH.

Semin Liver Dis. 2009 Nov;29(4):348-56. Epub 2009 Oct 13.PMID: 19826968 [PubMed - in process]Related articles

Text mining and manual curation of chemical-gene-disease networks for the comparative toxicogenomics database (CTD).

Wiegers TC, Davis AP, Cohen KB, Hirschman L, Mattingly CJ.

BMC Bioinformatics. 2009 Oct 8;10:326.PMID: 19814812 [PubMed - in process]Related articlesFree article

CYP2A13, ADH1B, and ADH1C Gene Polymorphisms and Pancreatic Cancer Risk.

Mohelnikova-Duchonova B, Vrana D, Holcatova I, Ryska M, Smerhovsky Z, Soucek P.

Pancreas. 2009 Oct 2. [Epub ahead of print]PMID: 19812523 [PubMed - as supplied by publisher]Related articles

Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment.

Zhang L, Freeman LE, Nakamura J, Hecht SS, Vandenberg JJ, Smith MT, Sonawane BR.

Environ Mol Mutagen. 2009 Sep 29. [Epub ahead of print]PMID: 19790261 [PubMed - as supplied by publisher]Related articles

The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population.

Vrana D, Pikhart H, Mohelnikova-Duchonova B, Holcatova I, Strnad R, Slamova A, Schejbalova M, Ryska M, Susova S, Soucek P.

Mutat Res. 2009 Sep 26. [Epub ahead of print]PMID: 19786118 [PubMed - as supplied by publisher]Related articles

Looking back to the future: from the development of the gene concept to toxicogenomics.

Choudhuri S.

Toxicol Mech Methods. 2009 May;19(4):263-77. Review.PMID: 19778216 [PubMed - indexed for MEDLINE]Related articles

Genotoxicity of cigarette smoking in maternal and newborn lymphocytes.

de Assis KR, Ladeira MS, Bueno RC, Dos Santos BF, Dalben I, Salvadori DM.

Mutat Res. 2009 Sep-Oct;679(1-2):72-8. Epub 2009 Feb 11.PMID: 19773089 [PubMed - in process]Related articles

Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety.

Anderson N, Meier T, Borlak J.

Toxicol Sci. 2009 Dec;112(2):507-20. Epub 2009 Sep 21.PMID: 19770483 [PubMed - in process]Related articles

Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

Kondo C, Minowa Y, Uehara T, Okuno Y, Nakatsu N, Ono A, Maruyama T, Kato I, Yamate J, Yamada H, Ohno Y, Urushidani T.

Toxicology. 2009 Nov 9;265(1-2):15-26. Epub 2009 Sep 15.PMID: 19761811 [PubMed - indexed for MEDLINE]Related articles

Global transcriptome analysis of the Mycobacterium bovis BCG response to sodium hypochlorite.

Jang HJ, Nde C, Toghrol F, Bentley WE.

Appl Microbiol Biotechnol. 2009 Nov;85(1):127-40.PMID: 19756581 [PubMed - in process]Related articles

Human cell toxicogenomic analysis of bromoacetic acid: A regulated drinking water disinfection by-product.

Muellner MG, Attene-Ramos MS, Hudson ME, Wagner ED, Plewa MJ.

Environ Mol Mutagen. 2009 Sep 14. [Epub ahead of print]PMID: 19753638 [PubMed - as supplied by publisher]Related articles

Impact of the circadian clock on in vitro genotoxic risk assessment assays.

Destici E, Oklejewicz M, Nijman R, Tamanini F, van der Horst GT.

Mutat Res. 2009 Sep 12. [Epub ahead of print]PMID: 19751845 [PubMed - as supplied by publisher]Related articles

Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead.

Ruden DM, Chen L, Possidente D, Possidente B, Rasouli P, Wang L, Lu X, Garfinkel MD, Hirsch HV, Page GP.

Neurotoxicology. 2009 Nov;30(6):898-914. Epub 2009 Sep 6.PMID: 19737576 [PubMed - in process]Related articles

Gene expression profiling in rat liver treated with compounds inducing elevation of bilirubin.

Hirode M, Horinouchi A, Uehara T, Ono A, Miyagishima T, Yamada H, Nagao T, Ohno Y, Urushidani T.

Hum Exp Toxicol. 2009 Apr;28(4):231-44.PMID: 19734275 [PubMed - in process]Related articles