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Items: 1 to 20 of 39

1.

IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

Chakrabarty P, Li A, Ceballos-Diaz C, Eddy JA, Funk CC, Moore B, DiNunno N, Rosario AM, Cruz PE, Verbeeck C, Sacino A, Nix S, Janus C, Price ND, Das P, Golde TE.

Neuron. 2015 Feb 4;85(3):519-33. doi: 10.1016/j.neuron.2014.11.020. Epub 2015 Jan 22.

2.

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.

Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL.

J Neurosci. 2014 Mar 12;34(11):3826-40. doi: 10.1523/JNEUROSCI.5171-13.2014.

3.

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.

Verbeeck C, Deng Q, Dejesus-Hernandez M, Taylor G, Ceballos-Diaz C, Kocerha J, Golde T, Das P, Rademakers R, Dickson DW, Kukar T.

Mol Neurodegener. 2012 Oct 10;7:53. doi: 10.1186/1750-1326-7-53.

4.

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology.

Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE.

Mol Neurodegener. 2012 Aug 14;7:39. doi: 10.1186/1750-1326-7-39.

5.

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition.

Chakrabarty P, Tianbai L, Herring A, Ceballos-Diaz C, Das P, Golde TE.

Mol Neurodegener. 2012 Jul 29;7:36. doi: 10.1186/1750-1326-7-36.

6.

Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.

Hanna A, Iremonger K, Das P, Dickson D, Golde T, Janus C.

Alzheimers Res Ther. 2012 Jun 14;4(3):21. doi: 10.1186/alzrt124.

7.

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains.

Moore BD, Chakrabarty P, Levites Y, Kukar TL, Baine AM, Moroni T, Ladd TB, Das P, Dickson DW, Golde TE.

Alzheimers Res Ther. 2012 May 23;4(3):18. doi: 10.1186/alzrt121.

8.

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.

Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, Golde TE.

J Biol Chem. 2011 Nov 18;286(46):39804-12. doi: 10.1074/jbc.M111.274696. Epub 2011 Aug 25.

9.

Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.

Chakrabarty P, Ceballos-Diaz C, Lin WL, Beccard A, Jansen-West K, McFarland NR, Janus C, Dickson D, Das P, Golde TE.

Nat Neurosci. 2011 Jun;14(6):694-6. doi: 10.1038/nn.2829. Epub 2011 May 15.

10.

Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy.

Wang A, Das P, Switzer RC 3rd, Golde TE, Jankowsky JL.

J Neurosci. 2011 Mar 16;31(11):4124-36. doi: 10.1523/JNEUROSCI.5077-10.2011.

11.

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo.

Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, Golde TE.

Mol Neurodegener. 2011 Feb 16;6:16. doi: 10.1186/1750-1326-6-16.

12.

Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.

Meckler X, Roseman J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, Thinakaran G.

J Neurosci. 2010 Dec 1;30(48):16160-9. doi: 10.1523/JNEUROSCI.4436-10.2010.

13.

IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice.

Chakrabarty P, Ceballos-Diaz C, Beccard A, Janus C, Dickson D, Golde TE, Das P.

J Immunol. 2010 May 1;184(9):5333-43. doi: 10.4049/jimmunol.0903382. Epub 2010 Apr 5.

14.

Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.

Chakrabarty P, Jansen-West K, Beccard A, Ceballos-Diaz C, Levites Y, Verbeeck C, Zubair AC, Dickson D, Golde TE, Das P.

FASEB J. 2010 Feb;24(2):548-59. doi: 10.1096/fj.09-141754. Epub 2009 Oct 13.

15.

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.

Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ.

Mol Neurodegener. 2009 May 6;4:19. doi: 10.1186/1750-1326-4-19.

16.

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.

McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG.

Neurobiol Dis. 2009 Apr;34(1):163-77.

17.

Quantitative and mechanistic studies of Abeta immunotherapy.

Golde TE, Das P, Levites Y.

CNS Neurol Disord Drug Targets. 2009 Mar;8(1):31-49. Review.

PMID:
19275635
18.

A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.

Spilman P, Lessard P, Sattavat M, Bush C, Tousseyn T, Huang EJ, Giles K, Golde T, Das P, Fauq A, Prusiner SB, Dearmond SJ.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10595-600. doi: 10.1073/pnas.0803671105. Epub 2008 Jul 22.

19.

Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells.

Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA.

Blood. 2008 Sep 1;112(5):1813-21. doi: 10.1182/blood-2008-03-144980. Epub 2008 Jun 11.

20.

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.

Buxbaum JN, Ye Z, Reixach N, Friske L, Levy C, Das P, Golde T, Masliah E, Roberts AR, Bartfai T.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2681-6. doi: 10.1073/pnas.0712197105. Epub 2008 Feb 12.

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