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Results: 1 to 20 of 86

Select item 237604811.

Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, Depinho RA, Cantley LC, Kimmelman AC.

Nature. 2013 Jun 12. doi: 10.1038/nature12317. [Epub ahead of print] No abstract available.

PMID:: 23760481; [PubMed - as supplied by publisher]

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Select item 237167172.

Tyrosine Kinase BMX Phosphorylates Phosphotyrosine-Primed Motif Mediating the Activation of Multiple Receptor Tyrosine Kinases.

Chen S, Jiang X, Gewinner CA, Asara JM, Simon NI, Cai C, Cantley LC, Balk SP.

Sci Signal. 2013 May 28;6(277):ra40. doi: 10.1126/scisignal.2003936.

PMID:: 23716717; [PubMed - in process]

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Select item 237151543.

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer.

Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman AC, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK.

Cancer Discov. 2013 May 28. [Epub ahead of print]

PMID:: 23715154; [PubMed - as supplied by publisher]

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Select item 236667604.

Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism.

Shinoda G, Shyh-Chang N, de Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ.

Stem Cells. 2013 May 10. doi: 10.1002/stem.1423. [Epub ahead of print]

PMID:: 23666760; [PubMed - as supplied by publisher]

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Select item 236444685.

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.

Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Bryan Tsou MF.

Nat Cell Biol. 2013 Jun;15(6):591-601. doi: 10.1038/ncb2739. Epub 2013 May 5.

PMID:: 23644468; [PubMed - in process]

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Select item 236043196.

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G.

Nat Cell Biol. 2013 May;15(5):491-501. doi: 10.1038/ncb2720. Epub 2013 Apr 21.

PMID:: 23604319; [PubMed - in process]

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Select item 235499157.

Structure of a protozoan virus from the human genitourinary parasite Trichomonas vaginalis.

Parent KN, Takagi Y, Cardone G, Olson NH, Ericsson M, Yang M, Lee Y, Asara JM, Fichorova RN, Baker TS, Nibert ML.

MBio. 2013 Apr 2;4(2). doi:pii: e00056-13. 10.1128/mBio.00056-13.

PMID:: 23549915; [PubMed - in process]

Free PMC Article

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Select item 235356018.

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC.

Nature. 2013 Apr 4;496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27.

PMID:: 23535601; [PubMed - indexed for MEDLINE]

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Select item 234538069.

AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC.

Mol Cell. 2013 Mar 28;49(6):1167-75. doi: 10.1016/j.molcel.2013.01.035. Epub 2013 Feb 28.

PMID:: 23453806; [PubMed - indexed for MEDLINE]

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Select item 2342970310.

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

Ben-Sahra I, Howell JJ, Asara JM, Manning BD.

Science. 2013 Mar 15;339(6125):1323-8. doi: 10.1126/science.1228792. Epub 2013 Feb 21.

PMID:: 23429703; [PubMed - indexed for MEDLINE]

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Select item 2334884011.

Centriole distal appendages promote membrane docking, leading to cilia initiation.

Tanos BE, Yang HJ, Soni R, Wang WJ, Macaluso FP, Asara JM, Tsou MF.

Genes Dev. 2013 Jan 15;27(2):163-8. doi: 10.1101/gad.207043.112.

PMID:: 23348840; [PubMed - indexed for MEDLINE]

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Select item 2332230212.

Loss of RBF1 changes glutamine catabolism.

Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ.

Genes Dev. 2013 Jan 15;27(2):182-96. doi: 10.1101/gad.206227.112. Epub 2013 Jan 15.

PMID:: 23322302; [PubMed - indexed for MEDLINE]

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Select item 2320711413.

Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates.

Webhofer C, Gormanns P, Reckow S, Lebar M, Maccarrone G, Ludwig T, Pütz B, Asara JM, Holsboer F, Sillaber I, Zieglgänsberger W, Turck CW.

J Psychiatr Res. 2013 Mar;47(3):289-98. doi: 10.1016/j.jpsychires.2012.11.003. Epub 2012 Dec 1.

PMID:: 23207114; [PubMed - in process]

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Select item 2311801214.

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.

Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC.

Science. 2013 Jan 11;339(6116):222-6. doi: 10.1126/science.1226603. Epub 2012 Nov 1.

PMID:: 23118012; [PubMed - indexed for MEDLINE]

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Select item 2302712815.

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.

Oncogene. 2012 Oct 1. doi: 10.1038/onc.2012.427. [Epub ahead of print]

PMID:: 23027128; [PubMed - as supplied by publisher]

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Select item 2298811016.

Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS).

Breitkopf SB, Yuan M, Pihan GA, Asara JM.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16190-5. doi: 10.1073/pnas.1212759109. Epub 2012 Sep 17.

PMID:: 22988110; [PubMed - indexed for MEDLINE]

Free PMC Article

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Select item 2293249217.

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization.

Mack HI, Zheng B, Asara JM, Thomas SM.

Autophagy. 2012 Aug;8(8):1197-214. doi: 10.4161/auto.20586. Epub 2012 Aug 1.

PMID:: 22932492; [PubMed - indexed for MEDLINE]

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Select item 2292275718.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG.

Nat Chem Biol. 2012 Oct;8(10):839-47. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

PMID:: 22922757; [PubMed - indexed for MEDLINE]

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Select item 2291575119.

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer.

Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, Cantley LC, Wulf GM.

Cancer Discov. 2012 Nov;2(11):1048-63. doi: 10.1158/2159-8290.CD-11-0336. Epub 2012 Aug 22.

PMID:: 22915751; [PubMed - indexed for MEDLINE]

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Select item 2280745620.

Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells.

Li M, Aliotta JM, Asara JM, Tucker L, Quesenberry P, Lally M, Ramratnam B.

Proteomics. 2012 Jul;12(13):2203-11. doi: 10.1002/pmic.201100376.

PMID:: 22807456; [PubMed - indexed for MEDLINE]

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44 free full-text articles in PubMed Central

Structure of a protozoan virus from the human genitourinary parasite Trichomonas vaginalis. [MBio. 2013]
Structure of a protozoan virus from the human genitourinary parasite Trichomonas vaginalis.
Parent KN, Takagi Y, Cardone G, Olson NH, Ericsson M, Yang M, Lee Y, Asara JM, Fichorova RN, Baker TS, et al. MBio. 2013 Apr 2; 4(2). Epub 2013 Apr 2.
Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS). [Proc Natl Acad Sci U S A. 2012]
Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS).
Breitkopf SB, Yuan M, Pihan GA, Asara JM. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16190-5. Epub 2012 Sep 17.
SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. [Cell Rep. 2012]
SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, et al. Cell Rep. 2012 May 31; 1(5):434-43.