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Items: 1 to 20 of 56

1.

Polymorphisms in mismatch repair genes are associated with risk and microsatellite instability of gastric cancer, and interact with life exposures.

Zhu H, Li X, Zhang X, Chen D, Li D, Ren J, Gu H, Shu Y, Wang D.

Gene. 2016 Mar 15;579(1):52-7. doi: 10.1016/j.gene.2015.12.050. Epub 2015 Dec 24.

PMID:
26724419
2.

Chromothripsis and Kataegis Induced by Telomere Crisis.

Maciejowski J, Li Y, Bosco N, Campbell PJ, de Lange T.

Cell. 2015 Dec 17;163(7):1641-54. doi: 10.1016/j.cell.2015.11.054.

PMID:
26687355
3.

Gain-of-function somatic mutations contribute to inflammation and blood vessel damage that lead to Alzheimer dementia: a hypothesis.

Marchesi VT.

FASEB J. 2016 Feb;30(2):503-6. doi: 10.1096/fj.15-282285. Epub 2015 Nov 2.

PMID:
26527064
4.

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N.

Immunity. 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25.

PMID:
26320659
5.

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.

Gray EE, Treuting PM, Woodward JJ, Stetson DB.

J Immunol. 2015 Sep 1;195(5):1939-43. doi: 10.4049/jimmunol.1500969. Epub 2015 Jul 29.

PMID:
26223655
6.

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome.

Lim YW, Sanz LA, Xu X, Hartono SR, Chédin F.

Elife. 2015 Jul 16;4. doi: 10.7554/eLife.08007.

7.

Enriching CRISPR-Cas9 targeted cells by co-targeting the HPRT gene.

Liao S, Tammaro M, Yan H.

Nucleic Acids Res. 2015 Nov 16;43(20):e134. doi: 10.1093/nar/gkv675. Epub 2015 Jun 29.

8.

Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.

Yuan F, Dutta T, Wang L, Song L, Gu L, Qian L, Benitez A, Ning S, Malhotra A, Deutscher MP, Zhang Y.

J Biol Chem. 2015 May 22;290(21):13344-53. doi: 10.1074/jbc.M115.653915. Epub 2015 Apr 8.

9.

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.

Grieves JL, Fye JM, Harvey S, Grayson JM, Hollis T, Perrino FW.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5117-22. doi: 10.1073/pnas.1423804112. Epub 2015 Apr 6.

10.

Genome-wide analysis of 5-hmC in the peripheral blood of systemic lupus erythematosus patients using an hMeDIP-chip.

Sui W, Tan Q, Yang M, Yan Q, Lin H, Ou M, Xue W, Chen J, Zou T, Jing H, Guo L, Cao C, Sun Y, Cui Z, Dai Y.

Int J Mol Med. 2015 May;35(5):1467-79. doi: 10.3892/ijmm.2015.2149. Epub 2015 Mar 19.

PMID:
25813249
11.

Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release.

Cuadrado E, Michailidou I, van Bodegraven EJ, Jansen MH, Sluijs JA, Geerts D, Couraud PO, De Filippis L, Vescovi AL, Kuijpers TW, Hol EM.

J Immunol. 2015 Apr 15;194(8):3623-33. doi: 10.4049/jimmunol.1401334. Epub 2015 Mar 13.

12.

Human disease phenotypes associated with mutations in TREX1.

Rice GI, Rodero MP, Crow YJ.

J Clin Immunol. 2015 Apr;35(3):235-43. doi: 10.1007/s10875-015-0147-3. Epub 2015 Mar 4. Review.

PMID:
25731743
13.

Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1.

Crow YJ, Chase DS, Lowenstein Schmidt J, Szynkiewicz M, Forte GM, Gornall HL, Oojageer A, Anderson B, Pizzino A, Helman G, Abdel-Hamid MS, Abdel-Salam GM, Ackroyd S, Aeby A, Agosta G, Albin C, Allon-Shalev S, Arellano M, Ariaudo G, Aswani V, Babul-Hirji R, Baildam EM, Bahi-Buisson N, Bailey KM, Barnerias C, Barth M, Battini R, Beresford MW, Bernard G, Bianchi M, Billette de Villemeur T, Blair EM, Bloom M, Burlina AB, Carpanelli ML, Carvalho DR, Castro-Gago M, Cavallini A, Cereda C, Chandler KE, Chitayat DA, Collins AE, Sierra Corcoles C, Cordeiro NJ, Crichiutti G, Dabydeen L, Dale RC, D'Arrigo S, De Goede CG, De Laet C, De Waele LM, Denzler I, Desguerre I, Devriendt K, Di Rocco M, Fahey MC, Fazzi E, Ferrie CD, Figueiredo A, Gener B, Goizet C, Gowrinathan NR, Gowrishankar K, Hanrahan D, Isidor B, Kara B, Khan N, King MD, Kirk EP, Kumar R, Lagae L, Landrieu P, Lauffer H, Laugel V, La Piana R, Lim MJ, Lin JP, Linnankivi T, Mackay MT, Marom DR, Marques Lourenço C, McKee SA, Moroni I, Morton JE, Moutard ML, Murray K, Nabbout R, Nampoothiri S, Nunez-Enamorado N, Oades PJ, Olivieri I, Ostergaard JR, Pérez-Dueñas B, Prendiville JS, Ramesh V, Rasmussen M, Régal L, Ricci F, Rio M, Rodriguez D, Roubertie A, Salvatici E, Segers KA, Sinha GP, Soler D, Spiegel R, Stödberg TI, Straussberg R, Swoboda KJ, Suri M, Tacke U, Tan TY, te Water Naude J, Wee Teik K, Thomas MM, Till M, Tonduti D, Valente EM, Van Coster RN, van der Knaap MS, Vassallo G, Vijzelaar R, Vogt J, Wallace GB, Wassmer E, Webb HJ, Whitehouse WP, Whitney RN, Zaki MS, Zuberi SM, Livingston JH, Rozenberg F, Lebon P, Vanderver A, Orcesi S, Rice GI.

Am J Med Genet A. 2015 Feb;167A(2):296-312. doi: 10.1002/ajmg.a.36887. Epub 2015 Jan 16.

14.

Familial chilblain lupus due to a novel mutation in the exonuclease III domain of 3' repair exonuclease 1 (TREX1).

Günther C, Berndt N, Wolf C, Lee-Kirsch MA.

JAMA Dermatol. 2015 Apr;151(4):426-31. doi: 10.1001/jamadermatol.2014.3438.

PMID:
25517357
15.

Neuropathology and genetics of cerebroretinal vasculopathies.

Kolar GR, Kothari PH, Khanlou N, Jen JC, Schmidt RE, Vinters HV.

Brain Pathol. 2014 Sep;24(5):510-8. doi: 10.1111/bpa.12178. Review.

PMID:
25323666
16.

The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response.

Miyazaki T, Kim YS, Yoon J, Wang H, Suzuki T, Morse HC 3rd.

J Biol Chem. 2014 Nov 21;289(47):32548-58. doi: 10.1074/jbc.M114.547331. Epub 2014 Oct 2.

17.

TREX1 C-terminal frameshift mutations in the systemic variant of retinal vasculopathy with cerebral leukodystrophy.

DiFrancesco JC, Novara F, Zuffardi O, Forlino A, Gioia R, Cossu F, Bolognesi M, Andreoni S, Saracchi E, Frigeni B, Stellato T, Tolnay M, Winkler DT, Remida P, Isimbaldi G, Ferrarese C.

Neurol Sci. 2015 Feb;36(2):323-30. doi: 10.1007/s10072-014-1944-9. Epub 2014 Sep 12.

PMID:
25213617
18.

Genetic variation in Trex1 affects HIV-1 disease progression.

Booiman T, Setiawan LC, Kootstra NA.

AIDS. 2014 Nov 13;28(17):2517-21. doi: 10.1097/QAD.0000000000000436.

PMID:
25162766
19.

Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing.

Ellyard JI, Jerjen R, Martin JL, Lee AY, Field MA, Jiang SH, Cappello J, Naumann SK, Andrews TD, Scott HS, Casarotto MG, Goodnow CC, Chaitow J, Pascual V, Hertzog P, Alexander SI, Cook MC, Vinuesa CG.

Arthritis Rheumatol. 2014 Dec;66(12):3382-6.

20.

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors.

Eckard SC, Rice GI, Fabre A, Badens C, Gray EE, Hartley JL, Crow YJ, Stetson DB.

Nat Immunol. 2014 Sep;15(9):839-45. doi: 10.1038/ni.2948. Epub 2014 Jul 27.

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