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    Results: 1 to 20 of 91

    1.

    Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

    Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T.

    Cell. 2013 Feb 28;152(5):1008-20. doi: 10.1016/j.cell.2013.01.056.

    PMID:
    23452850
    [PubMed - indexed for MEDLINE]
    2.

    Interplay between menin and K-Ras in regulating lung adenocarcinoma.

    Wu Y, Feng ZJ, Gao SB, Matkar S, Xu B, Duan HB, Lin X, Li SH, Hua X, Jin GH.

    J Biol Chem. 2012 Nov 16;287(47):40003-11. doi: 10.1074/jbc.M112.382416. Epub 2012 Oct 1.

    PMID:
    23027861
    [PubMed - indexed for MEDLINE]
    3.

    Constitutional NRAS mutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia.

    Kraoua L, Journel H, Bonnet P, Amiel J, Pouvreau N, Baumann C, Verloes A, Cavé H.

    Am J Med Genet A. 2012 Oct;158A(10):2407-11. doi: 10.1002/ajmg.a.35513. Epub 2012 Aug 7.

    PMID:
    22887781
    [PubMed - indexed for MEDLINE]
    4.

    Case report: Noonan syndrome with multiple giant cell lesions and review of the literature.

    Karbach J, Coerdt W, Wagner W, Bartsch O.

    Am J Med Genet A. 2012 Sep;158A(9):2283-9. doi: 10.1002/ajmg.a.35493. Epub 2012 Jul 27. Review.

    PMID:
    22848035
    [PubMed - indexed for MEDLINE]
    5.

    RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.

    Saha M, Carriere A, Cheerathodi M, Zhang X, Lavoie G, Rush J, Roux PP, Ballif BA.

    Biochem J. 2012 Oct 1;447(1):159-66. doi: 10.1042/BJ20120938.

    PMID:
    22827337
    [PubMed - indexed for MEDLINE]
    6.

    Response to growth hormone therapy in children with Noonan syndrome: correlation with or without PTPN11 gene mutation.

    Choi JH, Lee BH, Jung CW, Kim YM, Jin HY, Kim JM, Kim GH, Hwang JS, Yang SW, Lee J, Yoo HW.

    Horm Res Paediatr. 2012;77(6):388-93.

    PMID:
    22777296
    [PubMed - indexed for MEDLINE]
    7.

    DOK3 negatively regulates LPS responses and endotoxin tolerance.

    Peng Q, O'Loughlin JL, Humphrey MB.

    PLoS One. 2012;7(6):e39967. doi: 10.1371/journal.pone.0039967. Epub 2012 Jun 27.

    PMID:
    22761938
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    8.

    Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.

    Kwan DH, Yung LY, Ye RD, Wong YH.

    J Cell Biochem. 2012 Nov;113(11):3486-97. doi: 10.1002/jcb.24225.

    PMID:
    22711498
    [PubMed - indexed for MEDLINE]
    9.

    Prevalence of sequence variants in the RAS-mitogen activated protein kinase signaling pathway in pre-adolescent children with hypertrophic cardiomyopathy.

    Kaski JP, Syrris P, Shaw A, Alapi KZ, Cordeddu V, Esteban MT, Jenkins S, Ashworth M, Hammond P, Tartaglia M, McKenna WJ, Elliott PM.

    Circ Cardiovasc Genet. 2012 Jun;5(3):317-26. doi: 10.1161/CIRCGENETICS.111.960468. Epub 2012 May 15.

    PMID:
    22589294
    [PubMed - indexed for MEDLINE]
    10.

    Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers.

    Cheung HW, Du J, Boehm JS, He F, Weir BA, Wang X, Butaney M, Sequist LV, Luo B, Engelman JA, Root DE, Meyerson M, Golub TR, Jänne PA, Hahn WC.

    Cancer Discov. 2011 Dec;1(7):608-25. doi: 10.1158/2159-8290.CD-11-0046. Epub 2011 Oct 17.

    PMID:
    22586683
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    11.

    A rasopathy phenotype with severe congenital hypertrophic obstructive cardiomyopathy associated with a PTPN11 mutation and a novel variant in SOS1.

    Fahrner JA, Frazier A, Bachir S, Walsh MF, Applegate CD, Thompson R, Halushka MK, Murphy AM, Gunay-Aygun M.

    Am J Med Genet A. 2012 Jun;158A(6):1414-21. doi: 10.1002/ajmg.a.35363. Epub 2012 May 14.

    PMID:
    22585553
    [PubMed - indexed for MEDLINE]
    12.

    Decreased bone mineralization in children with Noonan syndrome: another consequence of dysregulated RAS MAPKinase pathway?

    Choudhry KS, Grover M, Tran AA, O'Brian Smith E, Ellis KJ, Lee BH.

    Mol Genet Metab. 2012 Jun;106(2):237-40. doi: 10.1016/j.ymgme.2012.04.003. Epub 2012 Apr 11.

    PMID:
    22551697
    [PubMed - indexed for MEDLINE]
    13.

    Alterations in RAS-MAPK genes in 200 Spanish patients with Noonan and other neuro-cardio-facio-cutaneous syndromes. Genotype and cardiopathy.

    Ezquieta B, Santomé JL, Carcavilla A, Guillén-Navarro E, Pérez-Aytés A, Sánchez del Pozo J, García-Miñaur S, Castillo E, Alonso M, Vendrell T, Santana A, Maroto E, Galbis L.

    Rev Esp Cardiol (Engl Ed). 2012 May;65(5):447-55. doi: 10.1016/j.recesp.2011.12.016. Epub 2012 Mar 31. English, Spanish.

    PMID:
    22465605
    [PubMed - indexed for MEDLINE]
    14.

    Type II cGMP-dependent protein kinase inhibits EGF-induced MAPK/JNK signal transduction in breast cancer cells.

    Lan T, Chen Y, Sang J, Wu Y, Wang Y, Jiang L, Tao Y.

    Oncol Rep. 2012 Jun;27(6):2039-44. doi: 10.3892/or.2012.1726. Epub 2012 Mar 15.

    PMID:
    22427012
    [PubMed - indexed for MEDLINE]
    15.

    Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.

    Nag A, Monine M, Perelson AS, Goldstein B.

    PLoS One. 2012;7(3):e28758. doi: 10.1371/journal.pone.0028758. Epub 2012 Mar 1.

    PMID:
    22396725
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    16.

    Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.

    McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

    Biochemistry. 2012 Mar 13;51(10):2122-35. doi: 10.1021/bi3000534. Epub 2012 Mar 2.

    PMID:
    22360309
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    17.

    Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.

    Ferrero GB, Picco G, Baldassarre G, Flex E, Isella C, Cantarella D, Corà D, Chiesa N, Crescenzio N, Timeus F, Merla G, Mazzanti L, Zampino G, Rossi C, Silengo M, Tartaglia M, Medico E.

    Hum Mutat. 2012 Apr;33(4):703-9. doi: 10.1002/humu.22026. Epub 2012 Feb 14.

    PMID:
    22253195
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    18.

    SOS1 over-expression in genital skin fibroblasts from hirsute women: a putative role of the SOS1/RAS pathway in the pathogenesis of hirsutism.

    Minella D, Wannenes F, Biancolella M, Amati F, Testa B, Nardone A, Bueno S, Fabbri A, Lauro D, Novelli G, Moretti C.

    J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):615-26.

    PMID:
    22217993
    [PubMed - indexed for MEDLINE]
    19.

    Laminin-α1 LG4-5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-κB transcription factors but also has adverse effects.

    Zhou YW, Munoz J, Jiang D, Jarrett HW.

    Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C902-14. doi: 10.1152/ajpcell.00118.2011. Epub 2011 Dec 7.

    PMID:
    22159078
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    20.

    Short stature and its treatment in Turner and Noonan syndromes.

    Chacko EM, Rapaport R.

    Curr Opin Endocrinol Diabetes Obes. 2012 Feb;19(1):40-6. doi: 10.1097/MED.0b013e32834ed64e. Review.

    PMID:
    22157403
    [PubMed - indexed for MEDLINE]

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