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    Results: 1 to 20 of 36

    1.

    SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.

    Fleming NI, Jorissen RN, Mouradov D, Christie M, Sakthianandeswaren A, Palmieri M, Day F, Li S, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Zhu HJ, Mariadason JM, Burgess AW, Busam D, Zhao Q, Strausberg RL, Gibbs P, Sieber OM.

    Cancer Res. 2013 Jan 15;73(2):725-35. doi: 10.1158/0008-5472.CAN-12-2706. Epub 2012 Nov 8.

    PMID:
    23139211
    [PubMed - indexed for MEDLINE]
    2.

    Identification and analysis of the human hyaluronan synthase 1 gene promoter reveals Smad3- and Sp3-mediated transcriptional induction.

    Chen L, Neville RD, Michael DR, Martin J, Luo DD, Thomas DW, Phillips AO, Bowen T.

    Matrix Biol. 2012 Sep-Oct;31(7-8):373-9. doi: 10.1016/j.matbio.2012.10.002. Epub 2012 Nov 1.

    PMID:
    23123404
    [PubMed - indexed for MEDLINE]
    3.

    Smad3 linker phosphorylation attenuates Smad3 transcriptional activity and TGF-β1/Smad3-induced epithelial-mesenchymal transition in renal epithelial cells.

    Bae E, Kim SJ, Hong S, Liu F, Ooshima A.

    Biochem Biophys Res Commun. 2012 Oct 26;427(3):593-9. doi: 10.1016/j.bbrc.2012.09.103. Epub 2012 Sep 27.

    PMID:
    23022526
    [PubMed - indexed for MEDLINE]
    4.

    Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling.

    Hirschhorn T, Barizilay L, Smorodinsky NI, Ehrlich M.

    PLoS One. 2012;7(8):e43459. doi: 10.1371/journal.pone.0043459. Epub 2012 Aug 22.

    PMID:
    22927969
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    5.

    Long-term smoking mediated down-regulation of Smad3 induces resistance to carboplatin in non-small cell lung cancer.

    Samanta D, Kaufman J, Carbone DP, Datta PK.

    Neoplasia. 2012 Jul;14(7):644-55.

    PMID:
    22904681
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    6.

    Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.

    Kohn EA, Yang YA, Du Z, Nagano Y, Van Schyndle CM, Herrmann MA, Heldman M, Chen JQ, Stuelten CH, Flanders KC, Wakefield LM.

    Mol Cancer Res. 2012 Oct;10(10):1389-99. doi: 10.1158/1541-7786.MCR-12-0136-T. Epub 2012 Aug 9.

    PMID:
    22878587
    [PubMed - indexed for MEDLINE]
    7.

    Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients.

    Kumarasinghe DD, Sullivan T, Kuliwaba JS, Fazzalari NL, Atkins GJ.

    Osteoarthritis Cartilage. 2012 Nov;20(11):1357-66. doi: 10.1016/j.joca.2012.07.005. Epub 2012 Jul 20.

    PMID:
    22820497
    [PubMed - indexed for MEDLINE]
    8.

    Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program.

    Estarás C, Akizu N, García A, Beltrán S, de la Cruz X, Martínez-Balbás MA.

    Development. 2012 Aug;139(15):2681-91. doi: 10.1242/dev.078345.

    PMID:
    22782721
    [PubMed - indexed for MEDLINE]
    Free Article
    9.

    Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway.

    Bruce DL, Macartney T, Yong W, Shou W, Sapkota GP.

    Cell Signal. 2012 Nov;24(11):1999-2006. doi: 10.1016/j.cellsig.2012.07.003. Epub 2012 Jul 7.

    PMID:
    22781750
    [PubMed - indexed for MEDLINE]
    10.

    Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.

    Mise N, Savai R, Yu H, Schwarz J, Kaminski N, Eickelberg O.

    J Biol Chem. 2012 Sep 7;287(37):31393-405. doi: 10.1074/jbc.M112.357624. Epub 2012 Jul 9.

    PMID:
    22778267
    [PubMed - indexed for MEDLINE]
    11.

    Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells.

    Boudreau HE, Casterline BW, Rada B, Korzeniowska A, Leto TL.

    Free Radic Biol Med. 2012 Oct 1;53(7):1489-99. doi: 10.1016/j.freeradbiomed.2012.06.016. Epub 2012 Jun 19.

    PMID:
    22728268
    [PubMed - indexed for MEDLINE]
    12.

    Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease.

    Wu Q, Wang J, Skubutyte R, Kepler CK, Huang Z, Anderson DG, Shapiro IM, Risbud MV.

    Arthritis Rheum. 2012 Oct;64(10):3324-33. doi: 10.1002/art.34570.

    PMID:
    22674034
    [PubMed - indexed for MEDLINE]
    13.

    Aggressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants.

    van der Linde D, van de Laar IM, Bertoli-Avella AM, Oldenburg RA, Bekkers JA, Mattace-Raso FU, van den Meiracker AH, Moelker A, van Kooten F, Frohn-Mulder IM, Timmermans J, Moltzer E, Cobben JM, van Laer L, Loeys B, De Backer J, Coucke PJ, De Paepe A, Hilhorst-Hofstee Y, Wessels MW, Roos-Hesselink JW.

    J Am Coll Cardiol. 2012 Jul 31;60(5):397-403. doi: 10.1016/j.jacc.2011.12.052. Epub 2012 May 23.

    PMID:
    22633655
    [PubMed - indexed for MEDLINE]
    14.

    Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.

    Grönroos E, Kingston IJ, Ramachandran A, Randall RA, Vizán P, Hill CS.

    Mol Cell Biol. 2012 Jul;32(14):2904-16. doi: 10.1128/MCB.00231-12. Epub 2012 May 21.

    PMID:
    22615489
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    15.

    Mechanical stretch increases Smad3-dependent CCN2 expression in inner meniscus cells.

    Furumatsu T, Kanazawa T, Miyake Y, Kubota S, Takigawa M, Ozaki T.

    J Orthop Res. 2012 Nov;30(11):1738-45. doi: 10.1002/jor.22142. Epub 2012 May 10.

    PMID:
    22576977
    [PubMed - indexed for MEDLINE]
    16.

    Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts.

    Nelson EF, Huang CW, Ewel JM, Chang AA, Yuan C.

    Mol Vis. 2012;18:479-87. Epub 2012 Feb 18.

    PMID:
    22393274
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    17.

    Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer.

    Samanta D, Gonzalez AL, Nagathihalli N, Ye F, Carbone DP, Datta PK.

    Cancer Prev Res (Phila). 2012 Mar;5(3):453-63. doi: 10.1158/1940-6207.CAPR-11-0313. Epub 2012 Jan 9.

    PMID:
    22232600
    [PubMed - indexed for MEDLINE]
    18.

    A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells.

    Di X, Andrews DM, Tucker CJ, Yu L, Moore AB, Zheng X, Castro L, Hermon T, Xiao H, Dixon D.

    Exp Mol Med. 2012 Apr 30;44(4):281-92. doi: 10.3858/emm.2012.44.4.024.

    PMID:
    22228119
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    19.

    Phenotypic spectrum of the SMAD3-related aneurysms-osteoarthritis syndrome.

    van de Laar IM, van der Linde D, Oei EH, Bos PK, Bessems JH, Bierma-Zeinstra SM, van Meer BL, Pals G, Oldenburg RA, Bekkers JA, Moelker A, de Graaf BM, Matyas G, Frohn-Mulder IM, Timmermans J, Hilhorst-Hofstee Y, Cobben JM, Bruggenwirth HT, van Laer L, Loeys B, De Backer J, Coucke PJ, Dietz HC, Willems PJ, Oostra BA, De Paepe A, Roos-Hesselink JW, Bertoli-Avella AM, Wessels MW.

    J Med Genet. 2012 Jan;49(1):47-57. doi: 10.1136/jmedgenet-2011-100382.

    PMID:
    22167769
    [PubMed - indexed for MEDLINE]
    20.

    Hypothesis: human umbilical cord blood-derived stromal cells regulate the Foxp3 expression of regulatory T cells through the TGF-β1/Smad3 pathway.

    Zhang C, Zhang X, Chen XH.

    Cell Biochem Biophys. 2012 Apr;62(3):463-6. doi: 10.1007/s12013-011-9328-8.

    PMID:
    22161558
    [PubMed - indexed for MEDLINE]

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