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    Results: 18

    1.

    Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.

    Hayes SD, Liu H, MacDonald E, Sanderson CM, Coulson JM, Clague MJ, Urbé S.

    J Biol Chem. 2012 Dec 14;287(51):43007-18. doi: 10.1074/jbc.M112.386938. Epub 2012 Oct 26.

    PMID:
    23105109
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    2.

    Reversal of multidrug resistance by gefitinib via RAF1/ERK pathway in pancreatic cancer cell line.

    Xiao Z, Ding N, Xiao G, Wang S, Wu Y, Tang L.

    Anat Rec (Hoboken). 2012 Dec;295(12):2122-8. doi: 10.1002/ar.22552. Epub 2012 Aug 21.

    PMID:
    22907845
    [PubMed - indexed for MEDLINE]
    3.

    Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.

    Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T.

    Mol Cell Biol. 2012 Oct;32(19):3872-90. doi: 10.1128/MCB.00751-12. Epub 2012 Jul 23.

    PMID:
    22826437
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    4.

    Prenatal diagnosis of hypoplastic left heart syndrome associated with Noonan Syndrome and de novo RAF1 mutation.

    Schulz S, Fröber R, Kraus C, Schneider U.

    Prenat Diagn. 2012 Oct;32(10):1016-8. doi: 10.1002/pd.3938. Epub 2012 Jul 23. No abstract available.

    PMID:
    22821648
    [PubMed - indexed for MEDLINE]
    5.

    Microduplication of 3p25.2 encompassing RAF1 associated with congenital heart disease suggestive of Noonan syndrome.

    Luo C, Yang YF, Yin BL, Chen JL, Huang C, Zhang WZ, Wang J, Zhang H, Yang JF, Tan ZP.

    Am J Med Genet A. 2012 Aug;158A(8):1918-23. doi: 10.1002/ajmg.a.35471. Epub 2012 Jul 11.

    PMID:
    22786616
    [PubMed - indexed for MEDLINE]
    6.

    Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.

    Deiss K, Kisker C, Lohse MJ, Lorenz K.

    J Biol Chem. 2012 Jul 6;287(28):23407-17. doi: 10.1074/jbc.M112.363812. Epub 2012 May 17.

    PMID:
    22610096
    [PubMed - indexed for MEDLINE]
    7.

    Two cases of LEOPARD syndrome--RAF1 mutations firstly described in children.

    Kuburović V, Vukomanović V, Carcavilla A, Ezquieta-Zubicaray B, Kuburović N.

    Turk J Pediatr. 2011 Nov-Dec;53(6):687-91.

    PMID:
    22389993
    [PubMed - indexed for MEDLINE]
    Free Article
    8.

    Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.

    Buscaino A, White SA, Houston DR, Lejeune E, Simmer F, de Lima Alves F, Diyora PT, Urano T, Bayne EH, Rappsilber J, Allshire RC.

    PLoS Genet. 2012 Feb;8(2):e1002499. doi: 10.1371/journal.pgen.1002499. Epub 2012 Feb 2.

    PMID:
    22319459
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    9.

    Is Raf1 a nexus for cardiac hypertrophic signaling in human disease?

    Del Re DP, Sadoshima J.

    J Mol Cell Cardiol. 2011 Jul;51(1):1-3. doi: 10.1016/j.yjmcc.2011.04.004. Epub 2011 Apr 22. No abstract available.

    PMID:
    21539844
    [PubMed - indexed for MEDLINE]
    10.

    EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling.

    Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC.

    Cancer Cell. 2011 Jan 18;19(1):86-100. doi: 10.1016/j.ccr.2010.10.035. Epub 2011 Jan 6.

    PMID:
    21215703
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    11.

    Hepatitis B virus regulates Raf1 expression in HepG2.2.15 cells by enhancing its promoter activity.

    Tian Y, Hu Y, Wang Z, Chen K, Zhang L, Wang L, Ren M, Huang A, Tang H.

    Arch Virol. 2011 May;156(5):869-74. doi: 10.1007/s00705-010-0901-z. Epub 2011 Jan 5.

    PMID:
    21207082
    [PubMed - indexed for MEDLINE]
    12.

    Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations.

    Longoni M, Moncini S, Cisternino M, Morella IM, Ferraiuolo S, Russo S, Mannarino S, Brazzelli V, Coi P, Zippel R, Venturin M, Riva P.

    Am J Med Genet A. 2010 Sep;152A(9):2176-84. doi: 10.1002/ajmg.a.33564.

    PMID:
    20683980
    [PubMed - indexed for MEDLINE]
    13.

    Decreased expression of FGFR1, SOS1, RAF1 genes in cryptorchidism.

    Hadziselimovic NO, de Geyter Ch, Demougin P, Oakeley EJ, Hadziselimovic F.

    Urol Int. 2010;84(3):353-61. doi: 10.1159/000288242. Epub 2010 Apr 13.

    PMID:
    20389169
    [PubMed - indexed for MEDLINE]
    Free Article
    14.

    Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein.

    Yoshiki S, Matsunaga-Udagawa R, Aoki K, Kamioka Y, Kiyokawa E, Matsuda M.

    Mol Biol Cell. 2010 Mar 15;21(6):1088-96. doi: 10.1091/mbc.E09-06-0455. Epub 2010 Jan 13.

    PMID:
    20071468
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    15.

    Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.

    Kobayashi T, Aoki Y, Niihori T, Cavé H, Verloes A, Okamoto N, Kawame H, Fujiwara I, Takada F, Ohata T, Sakazume S, Ando T, Nakagawa N, Lapunzina P, Meneses AG, Gillessen-Kaesbach G, Wieczorek D, Kurosawa K, Mizuno S, Ohashi H, David A, Philip N, Guliyeva A, Narumi Y, Kure S, Tsuchiya S, Matsubara Y.

    Hum Mutat. 2010 Mar;31(3):284-94. doi: 10.1002/humu.21187.

    PMID:
    20052757
    [PubMed - indexed for MEDLINE]
    16.

    Tumor spectrum in children with Noonan syndrome and SOS1 or RAF1 mutations.

    Denayer E, Devriendt K, de Ravel T, Van Buggenhout G, Smeets E, Francois I, Sznajer Y, Craen M, Leventopoulos G, Mutesa L, Vandecasseye W, Massa G, Kayserili H, Sciot R, Fryns JP, Legius E.

    Genes Chromosomes Cancer. 2010 Mar;49(3):242-52. doi: 10.1002/gcc.20735.

    PMID:
    19953625
    [PubMed - indexed for MEDLINE]
    17.

    Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.

    Jones DT, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP.

    Oncogene. 2009 May 21;28(20):2119-23. doi: 10.1038/onc.2009.73. Epub 2009 Apr 13.

    PMID:
    19363522
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    18.

    PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.

    Ko JM, Kim JM, Kim GH, Yoo HW.

    J Hum Genet. 2008;53(11-12):999-1006. doi: 10.1007/s10038-008-0343-6. Epub 2008 Nov 20.

    PMID:
    19020799
    [PubMed - indexed for MEDLINE]

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