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    Results: 1 to 20 of 39

    1.

    Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications.

    Corvetta D, Chayka O, Gherardi S, D'Acunto CW, Cantilena S, Valli E, Piotrowska I, Perini G, Sala A.

    J Biol Chem. 2013 Mar 22;288(12):8332-41. doi: 10.1074/jbc.M113.454280. Epub 2013 Jan 28.

    PMID:
    23362253
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    2.

    A MYCN-amplified cell line derived from a long-term event-free survivor among our sixteen established neuroblastoma cell lines.

    Sugimoto T, Gotoh T, Yagyu S, Kuroda H, Iehara T, Hosoi H, Ohta S, Ohira M, Nakagawara A.

    Cancer Lett. 2013 Apr 30;331(1):115-21. doi: 10.1016/j.canlet.2012.12.011. Epub 2012 Dec 23.

    PMID:
    23268333
    [PubMed - indexed for MEDLINE]
    3.

    MYCN-mediated overexpression of mitotic spindle regulatory genes and loss of p53-p21 function jointly support the survival of tetraploid neuroblastoma cells.

    Gogolin S, Batra R, Harder N, Ehemann V, Paffhausen T, Diessl N, Sagulenko V, Benner A, Gade S, Nolte I, Rohr K, König R, Westermann F.

    Cancer Lett. 2013 Apr 30;331(1):35-45. doi: 10.1016/j.canlet.2012.11.028. Epub 2012 Nov 24.

    PMID:
    23186832
    [PubMed - indexed for MEDLINE]
    4.

    Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.

    Veschi V, Petroni M, Cardinali B, Dominici C, Screpanti I, Frati L, Bartolazzi A, Gulino A, Giannini G.

    PLoS One. 2012;7(11):e49139. doi: 10.1371/journal.pone.0049139. Epub 2012 Nov 9.

    PMID:
    23152863
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    5.

    Redefining functional MYCN gene signatures in neuroblastoma.

    Shohet JM.

    Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19041-2. doi: 10.1073/pnas.1217598109. Epub 2012 Nov 8. No abstract available.

    PMID:
    23139408
    [PubMed - indexed for MEDLINE]
    Free Article
    6.

    Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.

    Valentijn LJ, Koster J, Haneveld F, Aissa RA, van Sluis P, Broekmans ME, Molenaar JJ, van Nes J, Versteeg R.

    Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19190-5. doi: 10.1073/pnas.1208215109. Epub 2012 Oct 22.

    PMID:
    23091029
    [PubMed - indexed for MEDLINE]
    Free Article
    7.

    Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome.

    Schramm A, Schowe B, Fielitz K, Heilmann M, Martin M, Marschall T, Köster J, Vandesompele J, Vermeulen J, de Preter K, Koster J, Versteeg R, Noguera R, Speleman F, Rahmann S, Eggert A, Morik K, Schulte JH.

    Br J Cancer. 2012 Oct 9;107(8):1409-17. doi: 10.1038/bjc.2012.391.

    PMID:
    23047593
    [PubMed - indexed for MEDLINE]
    8.

    LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

    Molenaar JJ, Domingo-Fernández R, Ebus ME, Lindner S, Koster J, Drabek K, Mestdagh P, van Sluis P, Valentijn LJ, van Nes J, Broekmans M, Haneveld F, Volckmann R, Bray I, Heukamp L, Sprüssel A, Thor T, Kieckbusch K, Klein-Hitpass L, Fischer M, Vandesompele J, Schramm A, van Noesel MM, Varesio L, Speleman F, Eggert A, Stallings RL, Caron HN, Versteeg R, Schulte JH.

    Nat Genet. 2012 Nov;44(11):1199-206. doi: 10.1038/ng.2436. Epub 2012 Oct 7.

    PMID:
    23042116
    [PubMed - indexed for MEDLINE]
    9.

    CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.

    Valli E, Trazzi S, Fuchs C, Erriquez D, Bartesaghi R, Perini G, Ciani E.

    Biochim Biophys Acta. 2012 Nov-Dec;1819(11-12):1173-85. doi: 10.1016/j.bbagrm.2012.08.001. Epub 2012 Aug 19.

    PMID:
    22921766
    [PubMed - indexed for MEDLINE]
    10.

    Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastoma.

    Schramm A, Köster J, Marschall T, Martin M, Schwermer M, Fielitz K, Büchel G, Barann M, Esser D, Rosenstiel P, Rahmann S, Eggert A, Schulte JH.

    Int J Cancer. 2013 Feb 1;132(3):E106-15. doi: 10.1002/ijc.27787. Epub 2012 Sep 26.

    PMID:
    22907398
    [PubMed - indexed for MEDLINE]
    11.

    NLRR1 enhances EGF-mediated MYCN induction in neuroblastoma and accelerates tumor growth in vivo.

    Hossain S, Takatori A, Nakamura Y, Suenaga Y, Kamijo T, Nakagawara A.

    Cancer Res. 2012 Sep 1;72(17):4587-96. doi: 10.1158/0008-5472.CAN-12-0943. Epub 2012 Jul 19.

    PMID:
    22815527
    [PubMed - indexed for MEDLINE]
    12.

    Inhibition of cyclin-dependent kinase 1-induced cell death in neuroblastoma cells through the microRNA-34a-MYCN-survivin pathway.

    Chen Y, Tsai YH, Tseng SH.

    Surgery. 2013 Jan;153(1):4-16. doi: 10.1016/j.surg.2012.03.030. Epub 2012 Jun 15.

    PMID:
    22703967
    [PubMed - indexed for MEDLINE]
    13.

    A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma.

    Sottile F, Gnemmi I, Cantilena S, D'Acunto WC, Sala A.

    Oncotarget. 2012 May;3(5):535-45.

    PMID:
    22619121
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    14.

    Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.

    Schönherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, Djos A, Martinsson T, Christensen JG, Palmer RH, Hallberg B.

    Oncogene. 2012 Dec 13;31(50):5193-200. doi: 10.1038/onc.2012.12. Epub 2012 Jan 30.

    PMID:
    22286764
    [PubMed - indexed for MEDLINE]
    15.

    Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression.

    Kruspig B, Nilchian A, Bejarano I, Orrenius S, Zhivotovsky B, Gogvadze V.

    Cell Mol Life Sci. 2012 Jun;69(12):2091-9. doi: 10.1007/s00018-012-0918-4.

    PMID:
    22286068
    [PubMed - indexed for MEDLINE]
    16.

    Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.

    Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA.

    Sci Transl Med. 2012 Jan 4;4(115):115ra3. doi: 10.1126/scitranslmed.3002977.

    PMID:
    22218692
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    17.

    Locoregional MYCN-amplified neuroblastoma.

    Morales La Madrid A, Volchenboum S, Gastier-Foster JM, Pyatt R, Liu D, Pytel P, Lavarino C, Rodriguez E, Cohn SL.

    Pediatr Blood Cancer. 2012 Oct;59(4):736-8. doi: 10.1002/pbc.24003. Epub 2012 Jan 1.

    PMID:
    22213566
    [PubMed - indexed for MEDLINE]
    18.

    miRNA expression profiling of the murine TH-MYCN neuroblastoma model reveals similarities with human tumors and identifies novel candidate miRNAs.

    Terrile M, Bryan K, Vaughan L, Hallsworth A, Webber H, Chesler L, Stallings RL.

    PLoS One. 2011;6(12):e28356. doi: 10.1371/journal.pone.0028356. Epub 2011 Dec 2.

    PMID:
    22164278
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    19.

    Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

    Korshunov A, Remke M, Kool M, Hielscher T, Northcott PA, Williamson D, Pfaff E, Witt H, Jones DT, Ryzhova M, Cho YJ, Wittmann A, Benner A, Weiss WA, von Deimling A, Scheurlen W, Kulozik AE, Clifford SC, Peter Collins V, Westermann F, Taylor MD, Lichter P, Pfister SM.

    Acta Neuropathol. 2012 Apr;123(4):515-27. doi: 10.1007/s00401-011-0918-8. Epub 2011 Dec 9.

    PMID:
    22160402
    [PubMed - indexed for MEDLINE]
    20.

    Correlation between the number of segmental chromosome aberrations and the age at diagnosis of diploid neuroblastomas without MYCN amplification.

    Souzaki R, Tajiri T, Teshiba R, Kinoshita Y, Yosue R, Kohashi K, Oda Y, Taguchi T.

    J Pediatr Surg. 2011 Dec;46(12):2228-32. doi: 10.1016/j.jpedsurg.2011.09.005.

    PMID:
    22152855
    [PubMed - indexed for MEDLINE]

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