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Results: 1 to 20 of 39

1.

UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.

Kim JH, Sharma A, Dhar SS, Lee SH, Gu B, Chan CH, Lin HK, Lee MG.

Cancer Res. 2014 Mar 15;74(6):1705-17. doi: 10.1158/0008-5472.CAN-13-1896. Epub 2014 Feb 3.

PMID:
24491801
[PubMed - indexed for MEDLINE]
2.

Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.

Gossage L, Murtaza M, Slatter AF, Lichtenstein CP, Warren A, Haynes B, Marass F, Roberts I, Shanahan SJ, Claas A, Dunham A, May AP, Rosenfeld N, Forshew T, Eisen T.

Genes Chromosomes Cancer. 2014 Jan;53(1):38-51. doi: 10.1002/gcc.22116. Epub 2013 Oct 29.

PMID:
24166983
[PubMed - indexed for MEDLINE]
3.

Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines.

McLaughlin-Drubin ME, Park D, Munger K.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16175-80. doi: 10.1073/pnas.1310432110. Epub 2013 Sep 17.

PMID:
24046371
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.

Poon SL, Pang ST, McPherson JR, Yu W, Huang KK, Guan P, Weng WH, Siew EY, Liu Y, Heng HL, Chong SC, Gan A, Tay ST, Lim WK, Cutcutache I, Huang D, Ler LD, Nairismägi ML, Lee MH, Chang YH, Yu KJ, Chan-On W, Li BK, Yuan YF, Qian CN, Ng KF, Wu CF, Hsu CL, Bunte RM, Stratton MR, Futreal PA, Sung WK, Chuang CK, Ong CK, Rozen SG, Tan P, Teh BT.

Sci Transl Med. 2013 Aug 7;5(197):197ra101. doi: 10.1126/scitranslmed.3006086.

PMID:
23926199
[PubMed - indexed for MEDLINE]
5.

MLL2 and KDM6A mutations in patients with Kabuki syndrome.

Miyake N, Koshimizu E, Okamoto N, Mizuno S, Ogata T, Nagai T, Kosho T, Ohashi H, Kato M, Sasaki G, Mabe H, Watanabe Y, Yoshino M, Matsuishi T, Takanashi J, Shotelersuk V, Tekin M, Ochi N, Kubota M, Ito N, Ihara K, Hara T, Tonoki H, Ohta T, Saito K, Matsuo M, Urano M, Enokizono T, Sato A, Tanaka H, Ogawa A, Fujita T, Hiraki Y, Kitanaka S, Matsubara Y, Makita T, Taguri M, Nakashima M, Tsurusaki Y, Saitsu H, Yoshiura K, Matsumoto N, Niikawa N.

Am J Med Genet A. 2013 Sep;161(9):2234-43. doi: 10.1002/ajmg.a.36072. Epub 2013 Aug 2.

PMID:
23913813
[PubMed - indexed for MEDLINE]
6.

The mutational landscape of adenoid cystic carcinoma.

Ho AS, Kannan K, Roy DM, Morris LG, Ganly I, Katabi N, Ramaswami D, Walsh LA, Eng S, Huse JT, Zhang J, Dolgalev I, Huberman K, Heguy A, Viale A, Drobnjak M, Leversha MA, Rice CE, Singh B, Iyer NG, Leemans CR, Bloemena E, Ferris RL, Seethala RR, Gross BE, Liang Y, Sinha R, Peng L, Raphael BJ, Turcan S, Gong Y, Schultz N, Kim S, Chiosea S, Shah JP, Sander C, Lee W, Chan TA.

Nat Genet. 2013 Jul;45(7):791-8. doi: 10.1038/ng.2643. Epub 2013 May 19.

PMID:
23685749
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC.

Ibragimova I, Maradeo ME, Dulaimi E, Cairns P.

Epigenetics. 2013 May;8(5):486-93. doi: 10.4161/epi.24552. Epub 2013 May 1.

PMID:
23644518
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The histone demethylase UTX regulates stem cell migration and hematopoiesis.

Thieme S, Gyárfás T, Richter C, Özhan G, Fu J, Alexopoulou D, Muders MH, Michalk I, Jakob C, Dahl A, Klink B, Bandola J, Bachmann M, Schröck E, Buchholz F, Stewart AF, Weidinger G, Anastassiadis K, Brenner S.

Blood. 2013 Mar 28;121(13):2462-73. doi: 10.1182/blood-2012-08-452003. Epub 2013 Jan 30.

PMID:
23365460
[PubMed - indexed for MEDLINE]
Free Article
9.

Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate.

Lindgren AM, Hoyos T, Talkowski ME, Hanscom C, Blumenthal I, Chiang C, Ernst C, Pereira S, Ordulu Z, Clericuzio C, Drautz JM, Rosenfeld JA, Shaffer LG, Velsher L, Pynn T, Vermeesch J, Harris DJ, Gusella JF, Liao EC, Morton CC.

Hum Genet. 2013 May;132(5):537-52. doi: 10.1007/s00439-013-1263-x. Epub 2013 Jan 25.

PMID:
23354975
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1.

Wang WP, Tzeng TY, Wang JY, Lee DC, Lin YH, Wu PC, Chen YP, Chiu IM, Chi YH.

PLoS One. 2012;7(12):e52556. doi: 10.1371/journal.pone.0052556. Epub 2012 Dec 18.

PMID:
23272250
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Histone lysine demethylases in breast cancer.

Paolicchi E, Crea F, Farrar WL, Green JE, Danesi R.

Crit Rev Oncol Hematol. 2013 May;86(2):97-103. doi: 10.1016/j.critrevonc.2012.11.008. Epub 2012 Dec 23.

PMID:
23266085
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The mitochondrial and autosomal mutation landscapes of prostate cancer.

Lindberg J, Mills IG, Klevebring D, Liu W, Neiman M, Xu J, Wikström P, Wiklund P, Wiklund F, Egevad L, Grönberg H.

Eur Urol. 2013 Apr;63(4):702-8. doi: 10.1016/j.eururo.2012.11.053. Epub 2012 Dec 5.

PMID:
23265383
[PubMed - indexed for MEDLINE]
13.

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

Dubuc AM, Remke M, Korshunov A, Northcott PA, Zhan SH, Mendez-Lago M, Kool M, Jones DT, Unterberger A, Morrissy AS, Shih D, Peacock J, Ramaswamy V, Rolider A, Wang X, Witt H, Hielscher T, Hawkins C, Vibhakar R, Croul S, Rutka JT, Weiss WA, Jones SJ, Eberhart CG, Marra MA, Pfister SM, Taylor MD.

Acta Neuropathol. 2013 Mar;125(3):373-84. doi: 10.1007/s00401-012-1070-9. Epub 2012 Nov 25.

PMID:
23184418
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.

Bunt J, Hasselt NA, Zwijnenburg DA, Koster J, Versteeg R, Kool M.

Acta Neuropathol. 2013 Mar;125(3):385-94. doi: 10.1007/s00401-012-1069-2. Epub 2012 Nov 18.

PMID:
23179372
[PubMed - indexed for MEDLINE]
15.

Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid.

Forthun RB, Sengupta T, Skjeldam HK, Lindvall JM, McCormack E, Gjertsen BT, Nilsen H.

PLoS One. 2012;7(11):e48992. doi: 10.1371/journal.pone.0048992. Epub 2012 Nov 14.

PMID:
23155442
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

KDM6A point mutations cause Kabuki syndrome.

Miyake N, Mizuno S, Okamoto N, Ohashi H, Shiina M, Ogata K, Tsurusaki Y, Nakashima M, Saitsu H, Niikawa N, Matsumoto N.

Hum Mutat. 2013 Jan;34(1):108-10. doi: 10.1002/humu.22229. Epub 2012 Oct 17.

PMID:
23076834
[PubMed - indexed for MEDLINE]
17.

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.

Liu J, Lee W, Jiang Z, Chen Z, Jhunjhunwala S, Haverty PM, Gnad F, Guan Y, Gilbert HN, Stinson J, Klijn C, Guillory J, Bhatt D, Vartanian S, Walter K, Chan J, Holcomb T, Dijkgraaf P, Johnson S, Koeman J, Minna JD, Gazdar AF, Stern HM, Hoeflich KP, Wu TD, Settleman J, de Sauvage FJ, Gentleman RC, Neve RM, Stokoe D, Modrusan Z, Seshagiri S, Shames DS, Zhang Z.

Genome Res. 2012 Dec;22(12):2315-27. doi: 10.1101/gr.140988.112. Epub 2012 Oct 2.

PMID:
23033341
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.

Shpargel KB, Sengoku T, Yokoyama S, Magnuson T.

PLoS Genet. 2012 Sep;8(9):e1002964. doi: 10.1371/journal.pgen.1002964. Epub 2012 Sep 27.

PMID:
23028370
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Loss of PBRM1 expression is associated with renal cell carcinoma progression.

Pawłowski R, Mühl SM, Sulser T, Krek W, Moch H, Schraml P.

Int J Cancer. 2013 Jan 15;132(2):E11-7. doi: 10.1002/ijc.27822. Epub 2012 Oct 3.

PMID:
22949125
[PubMed - indexed for MEDLINE]
20.

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.

Jiang W, Wang J, Zhang Y.

Cell Res. 2013 Jan;23(1):122-30. doi: 10.1038/cr.2012.119. Epub 2012 Aug 21.

PMID:
22907667
[PubMed - indexed for MEDLINE]
Free PMC Article

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