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Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory.
Neurobiol Dis. 2013 Jan;49:128-36. doi: 10.1016/j.nbd.2012.08.007. Epub 2012 Aug 25.
Neurobiol Dis. 2013.
PMID: 22926191
Free PMC article.
Despite the widespread use of antiretroviral therapy that effectively limits viral replication, memory impairment remains a dilemma for HIV infected people. In the CNS, HIV infection of astrocytes leads to the production of the HIV-1 Nef protein without viral …
Despite the widespread use of antiretroviral therapy that effectively limits viral replication, memory impairment remains a dilemma for H …
TGFbetaRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment.
Chompre G, Martinez-Orengo N, Cruz M, Porter JT, Noel RJ Jr.
Chompre G, et al.
J Neuroinflammation. 2019 Dec 11;16(1):262. doi: 10.1186/s12974-019-1664-4.
J Neuroinflammation. 2019.
PMID: 31829243
Free PMC article.
BACKGROUND: HIV-1-associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable viral loads and may be caused by early viral proteins expressed by latently infected cells. Astrocytes represent an HIV reservoir in th …
BACKGROUND: HIV-1-associated neurocognitive disorders (HAND) progression is related to continued inflammation despite undetectable vi …
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