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Results: 1 to 20 of 25

1.

Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.

Yamamoto T, Tsutsumi N, Tochio H, Ohnishi H, Kubota K, Kato Z, Shirakawa M, Kondo N.

Mol Immunol. 2014 Mar;58(1):66-76. doi: 10.1016/j.molimm.2013.11.008. Epub 2013 Dec 5.

PMID:
24316379
[PubMed - indexed for MEDLINE]
2.

IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B.

Over B, Ziegler S, Foermer S, Weber AN, Bode KA, Heeg K, Bekeredjian-Ding I.

Eur J Immunol. 2013 Jun;43(6):1630-42. doi: 10.1002/eji.201243217. Epub 2013 Apr 30.

PMID:
23519847
[PubMed - indexed for MEDLINE]
3.

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans.

von Bernuth H, Picard C, Puel A, Casanova JL.

Eur J Immunol. 2012 Dec;42(12):3126-35. doi: 10.1002/eji.201242683. Review.

PMID:
23255009
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Translational science and the hidden research system in universities and academic hospitals: a case study.

Lander B, Atkinson-Grosjean J.

Soc Sci Med. 2011 Feb;72(4):537-44. doi: 10.1016/j.socscimed.2010.11.019. Epub 2010 Nov 27.

PMID:
21168250
[PubMed - indexed for MEDLINE]
5.

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

Picard C, von Bernuth H, Ghandil P, Chrabieh M, Levy O, Arkwright PD, McDonald D, Geha RS, Takada H, Krause JC, Creech CB, Ku CL, Ehl S, Maródi L, Al-Muhsen S, Al-Hajjar S, Al-Ghonaium A, Day-Good NK, Holland SM, Gallin JI, Chapel H, Speert DP, Rodriguez-Gallego C, Colino E, Garty BZ, Roifman C, Hara T, Yoshikawa H, Nonoyama S, Domachowske J, Issekutz AC, Tang M, Smart J, Zitnik SE, Hoarau C, Kumararatne DS, Thrasher AJ, Davies EG, Bethune C, Sirvent N, de Ricaud D, Camcioglu Y, Vasconcelos J, Guedes M, Vitor AB, Rodrigo C, Almazán F, Méndez M, Aróstegui JI, Alsina L, Fortuny C, Reichenbach J, Verbsky JW, Bossuyt X, Doffinger R, Abel L, Puel A, Casanova JL.

Medicine (Baltimore). 2010 Nov;89(6):403-25. doi: 10.1097/MD.0b013e3181fd8ec3.

PMID:
21057262
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Toll-like receptor responses in IRAK-4-deficient neutrophils.

van Bruggen R, Drewniak A, Tool AT, Jansen M, van Houdt M, Geissler J, van den Berg TK, Chapel H, Kuijpers TW.

J Innate Immun. 2010;2(3):280-7. doi: 10.1159/000268288. Epub 2009 Dec 16.

PMID:
20375545
[PubMed - indexed for MEDLINE]
7.

Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.

Brown KL, Falsafi R, Kum W, Hamill P, Gardy JL, Davidson DJ, Turvey S, Finlay BB, Speert DP, Hancock RE.

J Transl Med. 2010 Jan 27;8:6. doi: 10.1186/1479-5876-8-6.

PMID:
20105294
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

IRAK-4 inhibitors for inflammation.

Wang Z, Wesche H, Stevens T, Walker N, Yeh WC.

Curr Top Med Chem. 2009;9(8):724-37. Review.

PMID:
19689377
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency.

Bouma G, Doffinger R, Patel SY, Peskett E, Sinclair JC, Barcenas-Morales G, Cerron-Gutierrez L, Kumararatne DS, Davies EG, Thrasher AJ, Burns SO.

Br J Haematol. 2009 Oct;147(1):153-6. doi: 10.1111/j.1365-2141.2009.07838.x. Epub 2009 Aug 5. No abstract available.

PMID:
19663824
[PubMed - indexed for MEDLINE]
10.

Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency.

Singh A, Zarember KA, Kuhns DB, Gallin JI.

J Immunol. 2009 May 15;182(10):6410-7. doi: 10.4049/jimmunol.0802512.

PMID:
19414794
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Flow cytometric investigation of neutrophil oxidative burst and apoptosis in physiological and pathological situations.

Elbim C, Lizard G.

Cytometry A. 2009 Jun;75(6):475-81. doi: 10.1002/cyto.a.20726. Review.

PMID:
19358285
[PubMed - indexed for MEDLINE]
Free Article
12.

Staphylococcal pericarditis, and liver and paratracheal abscesses as presentations in two new cases of interleukin-1 receptor associated kinase 4 deficiency.

Comeau JL, Lin TJ, Macken MB, Li B, Ku CL, von Bernuth H, Casanova JL, Issekutz AC.

Pediatr Infect Dis J. 2008 Feb;27(2):170-4. doi: 10.1097/INF.0b013e318157ad01.

PMID:
18174872
[PubMed - indexed for MEDLINE]
13.

Recurrent systemic pneumococcal disease and IRAK4 deficiency.

Turvey SE, Speert DP.

Pediatr Infect Dis J. 2007 Nov;26(11):1074; author reply 1074. No abstract available.

PMID:
17984826
[PubMed - indexed for MEDLINE]
14.

Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses.

Zhang SY, Jouanguy E, Sancho-Shimizu V, von Bernuth H, Yang K, Abel L, Picard C, Puel A, Casanova JL.

Immunol Rev. 2007 Dec;220:225-36. Review.

PMID:
17979850
[PubMed - indexed for MEDLINE]
15.

Inherited human IRAK-4 deficiency: an update.

Picard C, von Bernuth H, Ku CL, Yang K, Puel A, Casanova JL.

Immunol Res. 2007;38(1-3):347-52. Review.

PMID:
17917042
[PubMed - indexed for MEDLINE]
16.

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Maródi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, Casanova JL.

J Exp Med. 2007 Oct 1;204(10):2407-22. Epub 2007 Sep 24.

PMID:
17893200
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.

Hoarau C, Gérard B, Lescanne E, Henry D, François S, Lacapère JJ, El Benna J, Dang PM, Grandchamp B, Lebranchu Y, Gougerot-Pocidalo MA, Elbim C.

J Immunol. 2007 Oct 1;179(7):4754-65.

PMID:
17878374
[PubMed - indexed for MEDLINE]
Free Article
18.

Recurrent infection with genetically identical pneumococcal isolates in a patient with interleukin-1 receptor-associated kinase-4 deficiency.

Szabó J, Dobay O, Erdos M, Borbély A, Rozgonyi F, Maródi L.

J Med Microbiol. 2007 Jun;56(Pt 6):863-5.

PMID:
17510276
[PubMed - indexed for MEDLINE]
Free Article
19.

Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses.

McDonald DR, Brown D, Bonilla FA, Geha RS.

J Allergy Clin Immunol. 2006 Dec;118(6):1357-62. Epub 2006 Sep 25.

PMID:
17157666
[PubMed - indexed for MEDLINE]
20.

IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells.

Davidson DJ, Currie AJ, Bowdish DM, Brown KL, Rosenberger CM, Ma RC, Bylund J, Campsall PA, Puel A, Picard C, Casanova JL, Turvey SE, Hancock RE, Devon RS, Speert DP.

J Immunol. 2006 Dec 1;177(11):8202-11.

PMID:
17114497
[PubMed - indexed for MEDLINE]
Free PMC Article

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