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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1943 1
1946 1
1947 1
1948 2
1951 2
1952 1
1953 2
1954 1
1955 9
1956 8
1957 5
1958 3
1959 7
1960 7
1961 11
1962 11
1963 25
1964 50
1965 37
1966 45
1967 75
1968 76
1969 97
1970 81
1971 104
1972 103
1973 103
1974 101
1975 100
1976 108
1977 98
1978 100
1979 107
1980 102
1981 108
1982 140
1983 139
1984 145
1985 175
1986 144
1987 125
1988 128
1989 135
1990 144
1991 149
1992 192
1993 203
1994 207
1995 232
1996 321
1997 431
1998 571
1999 726
2000 883
2001 991
2002 1136
2003 1180
2004 1245
2005 1376
2006 1439
2007 1370
2008 1300
2009 1280
2010 1286
2011 1263
2012 1214
2013 1270
2014 1243
2015 1252
2016 1186
2017 1125
2018 1107
2019 1216
2020 1229
2021 1211
2022 1225
2023 1077
2024 342

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32,211 results

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Page 1
Homocysteine metabolism.
Selhub J. Selhub J. Annu Rev Nutr. 1999;19:217-46. doi: 10.1146/annurev.nutr.19.1.217. Annu Rev Nutr. 1999. PMID: 10448523 Review.
Severe hyperhomocysteinemia is due to rare genetic defects resulting in deficiencies in cystathionine beta synthase, methylenetetrahydrofolate reductase, or in enzymes involved in methyl-B12 synthesis and homocysteine methylation. ...More recent studies with human b …
Severe hyperhomocysteinemia is due to rare genetic defects resulting in deficiencies in cystathionine beta synthase, methylenetetrahy …
Homocysteine and Hyperhomocysteinaemia.
Zaric BL, Obradovic M, Bajic V, Haidara MA, Jovanovic M, Isenovic ER. Zaric BL, et al. Curr Med Chem. 2019;26(16):2948-2961. doi: 10.2174/0929867325666180313105949. Curr Med Chem. 2019. PMID: 29532755 Review.
Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans. ...Consequently, the level of the total Hcy in the serum is influenced by the presence or absence of these vitamins. An elevated level of the Hcy, hyperhomocysteinemia …
Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans. ...Consequently, the level of th …
Hyperhomocysteinemia and cardiovascular diseases.
Guieu R, Ruf J, Mottola G. Guieu R, et al. Ann Biol Clin (Paris). 2022 Feb 1;80(1):7-14. doi: 10.1684/abc.2021.1694. Ann Biol Clin (Paris). 2022. PMID: 35129442 Review.
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an intermediate metabolite in the methionine cycle. Hcy is present in plasma, with normal levels between 5 and 15 mumol/L, a slightly elevated level …
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, which is not acquired through the diet, but rather synthesized as an interm …
Homocysteine Modification in Protein Structure/Function and Human Disease.
Jakubowski H. Jakubowski H. Physiol Rev. 2019 Jan 1;99(1):555-604. doi: 10.1152/physrev.00003.2018. Physiol Rev. 2019. PMID: 30427275 Free article. Review.
Although homocysteine is considered to be a nonprotein amino acid, studies over the past 2 decades have led to discoveries of protein-related homocysteine metabolism and mechanisms by which homocysteine can become a component of proteins. Homocysteine- …
Although homocysteine is considered to be a nonprotein amino acid, studies over the past 2 decades have led to discoveries of protein …
Role of homocysteine in the development of cardiovascular disease.
Ganguly P, Alam SF. Ganguly P, et al. Nutr J. 2015 Jan 10;14:6. doi: 10.1186/1475-2891-14-6. Nutr J. 2015. PMID: 25577237 Free PMC article. Review.
The question, therefore, arises as to whether or not homocysteine is able to selectively stimulate the release of excitatory amino acids in stroke. ...The present review will thus summarize both central and peripheral effects of homocysteine and will highlight some …
The question, therefore, arises as to whether or not homocysteine is able to selectively stimulate the release of excitatory amino ac …
Hyperhomocysteinemia in Cardiovascular Diseases: Revisiting Observational Studies and Clinical Trials.
Guéant JL, Guéant-Rodriguez RM, Oussalah A, Zuily S, Rosenberg I. Guéant JL, et al. Thromb Haemost. 2023 Mar;123(3):270-282. doi: 10.1055/a-1952-1946. Epub 2022 Sep 28. Thromb Haemost. 2023. PMID: 36170884 Free article. Review.
We reviewed the main data of this controversy and formulated conclusions to be translated in clinical practice.Homocysteine-lowering trials have been performed in cardiovascular subjects with moderate but not intermediate/severe hyperhomocysteinemia despite the dose …
We reviewed the main data of this controversy and formulated conclusions to be translated in clinical practice.Homocysteine-lowering …
Homocysteine and Gliotoxicity.
Wyse ATS, Bobermin LD, Dos Santos TM, Quincozes-Santos A. Wyse ATS, et al. Neurotox Res. 2021 Jun;39(3):966-974. doi: 10.1007/s12640-021-00359-5. Epub 2021 Mar 30. Neurotox Res. 2021. PMID: 33786757 Review.
Severe hyperhomocysteinemic patients can present neurological symptoms and structural brain abnormalities, of which the pathogenesis is poorly understood. Moreover, a possible link between homocysteine (mild hyperhomocysteinemia) and neurodegenerative/neuropsychiatr …
Severe hyperhomocysteinemic patients can present neurological symptoms and structural brain abnormalities, of which the pathogenesis is poor …
Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID).
Hainsworth AH, Yeo NE, Weekman EM, Wilcock DM. Hainsworth AH, et al. Biochim Biophys Acta. 2016 May;1862(5):1008-17. doi: 10.1016/j.bbadis.2015.11.015. Epub 2015 Dec 9. Biochim Biophys Acta. 2016. PMID: 26689889 Free PMC article. Review.
Homocysteine is produced physiologically in all cells, and is present in plasma of healthy individuals (plasma [HCy]: 3-10muM). While rare genetic mutations (CBS, MTHFR) cause severe hyperhomocysteinemia ([HCy]: 100-200muM), mild-moderate hyperhomocysteinemia …
Homocysteine is produced physiologically in all cells, and is present in plasma of healthy individuals (plasma [HCy]: 3-10muM). While …
[Homocysteine metabolism].
Hashimoto T, Shinohara Y, Hasegawa H. Hashimoto T, et al. Yakugaku Zasshi. 2007 Oct;127(10):1579-92. doi: 10.1248/yakushi.127.1579. Yakugaku Zasshi. 2007. PMID: 17917419 Free article. Review. Japanese.
In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in children with elevated plasma homocysteine concentrations and homocystinuria. On the basis of this observation, he proposed that elevated plasma homocysteine (hyper …
In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in children with elevated plasma homocyst …
Hyperhomocysteinemia and thrombosis.
Lee R, Frenkel EP. Lee R, et al. Hematol Oncol Clin North Am. 2003 Feb;17(1):85-102. doi: 10.1016/s0889-8588(02)00090-4. Hematol Oncol Clin North Am. 2003. PMID: 12627664 Review.
Homocysteine remains an enigmatic marker for vascular disease. Studies have shown hyperhomocysteinemia is a risk factor for VTE, cerebrovascular disease, and coronary artery disease. ...Until there is evidence that treatment improves outcomes, testing for homocys …
Homocysteine remains an enigmatic marker for vascular disease. Studies have shown hyperhomocysteinemia is a risk factor for VT …
32,211 results
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