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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1966 1
1970 1
1975 1
1976 3
1977 2
1978 4
1979 3
1980 3
1981 4
1982 12
1983 18
1984 57
1985 173
1986 815
1987 2213
1988 3755
1989 4557
1990 5887
1991 6918
1992 7551
1993 8010
1994 8142
1995 9137
1996 9686
1997 9789
1998 10554
1999 10472
2000 10071
2001 10115
2002 9962
2003 10478
2004 11070
2005 11892
2006 12520
2007 13330
2008 13521
2009 13576
2010 14595
2011 15669
2012 16201
2013 16952
2014 17570
2015 17216
2016 17372
2017 16792
2018 16437
2019 16781
2020 18281
2021 18574
2022 17929
2023 16435
2024 5326

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425,982 results

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Page 1
Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011-2014).
Li X, Zhang L, Tian Y, Song Y, Zhan P, Liu X. Li X, et al. Expert Opin Ther Pat. 2014 Nov;24(11):1199-227. doi: 10.1517/13543776.2014.964685. Epub 2014 Oct 14. Expert Opin Ther Pat. 2014. PMID: 25313716 Review.
INTRODUCTION: There is a continuous need for next-generation non-nucleoside RT inhibitors (NNRTIs) with different resistance profiles, improved safety, excellent tolerability, and favorable physicochemical properties. ...Several newly emerging structure-based …
INTRODUCTION: There is a continuous need for next-generation non-nucleoside RT inhibitors (NNRTIs) with different resis …
Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.
Famiglini V, Silvestri R. Famiglini V, et al. Molecules. 2016 Feb 16;21(2):221. doi: 10.3390/molecules21020221. Molecules. 2016. PMID: 26891289 Free PMC article. Review.
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug res …
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since …
HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: SAR and Lead Optimization Using CoMFA and CoMSIA Studies (1995-2016).
Vanangamudi M, Poongavanam V, Namasivayam V. Vanangamudi M, et al. Curr Med Chem. 2017 Nov 17;24(34):3774-3812. doi: 10.2174/0929867324666170705122851. Curr Med Chem. 2017. PMID: 28685686 Review.
BACKGROUND: Design of inhibitors for HIV-1 reverse transcriptase inhibition (HIV-1 RT) is one of the successful chemotherapies for the treatment of HIV infection. Among the inhibitors available for HIV-1 RT, non-nu …
BACKGROUND: Design of inhibitors for HIV-1 reverse transcriptase inhibition (HIV-1 RT) is one of the succ …
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif.
Li W, Li X, De Clercq E, Zhan P, Liu X. Li W, et al. Eur J Med Chem. 2015 Sep 18;102:167-79. doi: 10.1016/j.ejmech.2015.07.043. Epub 2015 Jul 26. Eur J Med Chem. 2015. PMID: 26276432 Review.
The poor pharmacokinetics, side effects and particularly the rapid emergence of drug resistance compromise the efficiency of the clinically used anti-HIV drugs. Therefore, the discovery of novel and effective NNRTIs is still an extremely primary mission. Arylthioacetanilid …
The poor pharmacokinetics, side effects and particularly the rapid emergence of drug resistance compromise the efficiency of the clinically …
Rilpivirine.
Sanford M. Sanford M. Drugs. 2012 Mar 5;72(4):525-41. doi: 10.2165/11208590-000000000-00000. Drugs. 2012. PMID: 22356290 Review.
Rilpivirine is an orally administered, non-nucleoside reverse transcriptase inhibitor that is a component drug in combination therapy for antiretroviral-naive patients with HIV-1 infection. ...Rilpivirine 25 mg once daily recipients had a …
Rilpivirine is an orally administered, non-nucleoside reverse transcriptase inhibitor that is a component …
Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine.
Cihlar T, Ray AS. Cihlar T, et al. Antiviral Res. 2010 Jan;85(1):39-58. doi: 10.1016/j.antiviral.2009.09.014. Epub 2009 Nov 1. Antiviral Res. 2010. PMID: 19887088 Review.
Twenty-five years ago, nucleoside analog 3'-azidothymidine (AZT) was shown to efficiently block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts via the selective inhibition of HIV reverse transcriptase (RT) by its …
Twenty-five years ago, nucleoside analog 3'-azidothymidine (AZT) was shown to efficiently block the replication of HIV in cell cultur …
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future.
De Clercq E. De Clercq E. Chem Biodivers. 2004 Jan;1(1):44-64. doi: 10.1002/cbdv.200490012. Chem Biodivers. 2004. PMID: 17191775 Review.
Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent ingredient of the drug combination schemes that are currently used in the treatment of human immunodeficiency virus type 1 (HIV-1) infections. ...NNRTIs …
Non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent ingredient of the d …
Twenty years of HIV-1 non-nucleoside reverse transcriptase inhibitors: time to reevaluate their toxicity.
Blas-Garcia A, Esplugues JV, Apostolova N. Blas-Garcia A, et al. Curr Med Chem. 2011;18(14):2186-95. doi: 10.2174/092986711795656180. Curr Med Chem. 2011. PMID: 21521162 Review.
Twenty years of effective clinical application have consolidated non-nucleoside reverse transcriptase inhibitors (NNRTI) as essential components of the Highly Active Antiretroviral Therapy (HAART) employed in the treatment of Human Immunodeficie …
Twenty years of effective clinical application have consolidated non-nucleoside reverse transcriptase inhibit …
The HIV-1 non-nucleoside reverse transcriptase inhibitors (part V): capravirine and its analogues.
Li X, Zhan P, De Clercq E, Liu X. Li X, et al. Curr Med Chem. 2012;19(36):6138-49. Curr Med Chem. 2012. PMID: 22934811 Review.
Consequently, clinical trials were discontinued after phase IIb. Notwithstanding, with aim to obtain novel inhibitors against drug-resistant HIV-1 strains, an in-depth analysis of the particular binding mode of capravirine, together with the wide use of analogue-bas …
Consequently, clinical trials were discontinued after phase IIb. Notwithstanding, with aim to obtain novel inhibitors against drug-re …
Synthesis and anti-HIV activity of non-nucleoside reverse-transcriptase inhibitor DB02 phosphate derivatives based on water-soluble optimization.
Wang JB, Ma MD, Lu N, Yang YZ, Yang JX, Li YM, Xie CQ, Ma NY, Luo RH, Wang YP, Yang LM, Zhang HB, Zheng YT, He YP. Wang JB, et al. Drug Dev Res. 2023 May;84(3):423-432. doi: 10.1002/ddr.22036. Epub 2023 Feb 8. Drug Dev Res. 2023. PMID: 36751971
To improve the water solubility of anti-human immunodeficiency virus (HIV) agent DB02, an excellent non-nucleoside reverse-transcriptase inhibitor (NNRTI) obtained in our previous efforts, we designed and synthesized four phosphate deriva …
To improve the water solubility of anti-human immunodeficiency virus (HIV) agent DB02, an excellent non-nucleoside r …
425,982 results
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