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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1899 1
1905 1
1908 1
1912 1
1913 1
1917 1
1919 1
1922 1
1923 2
1924 1
1925 2
1926 5
1927 2
1928 5
1929 1
1930 4
1932 2
1934 2
1935 3
1936 1
1937 1
1938 1
1939 3
1940 2
1941 2
1942 2
1943 4
1944 3
1945 33
1946 123
1947 159
1948 152
1949 159
1950 232
1951 245
1952 245
1953 268
1954 282
1955 265
1956 402
1957 625
1958 729
1959 602
1960 471
1961 529
1962 563
1963 900
1964 1449
1965 1121
1966 1283
1967 1734
1968 2354
1969 2521
1970 2578
1971 2910
1972 2977
1973 2989
1974 3115
1975 3005
1976 2759
1977 2790
1978 2670
1979 3067
1980 3214
1981 3182
1982 3426
1983 3590
1984 3773
1985 3852
1986 3840
1987 3752
1988 3990
1989 4215
1990 4411
1991 4504
1992 4542
1993 4663
1994 4727
1995 4708
1996 4837
1997 5285
1998 5364
1999 5521
2000 5924
2001 6135
2002 6867
2003 7221
2004 7966
2005 8977
2006 10016
2007 10896
2008 11605
2009 12618
2010 13478
2011 14481
2012 15684
2013 16566
2014 17327
2015 17602
2016 17687
2017 18079
2018 18464
2019 18728
2020 19899
2021 19886
2022 18619
2023 16555
2024 5632

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428,128 results

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Page 1
Metformin in 2019.
Flory J, Lipska K. Flory J, et al. JAMA. 2019 May 21;321(19):1926-1927. doi: 10.1001/jama.2019.3805. JAMA. 2019. PMID: 31009043 Free PMC article. Review.
Metformin is the first-line pharmacologic treatment for type 2 diabetes and the most commonly prescribed drug for this condition worldwide, either alone or in combination with insulin or other glucose-lowering therapies. Metformin is a biguanide, a drug class of her …
Metformin is the first-line pharmacologic treatment for type 2 diabetes and the most commonly prescribed drug for this condition worldwide, …
Metformin: update on mechanisms of action and repurposing potential.
Foretz M, Guigas B, Viollet B. Foretz M, et al. Nat Rev Endocrinol. 2023 Aug;19(8):460-476. doi: 10.1038/s41574-023-00833-4. Epub 2023 May 2. Nat Rev Endocrinol. 2023. PMID: 37130947 Free PMC article. Review.
Early evidence highlighted the liver as the major organ involved in the effect of metformin on reducing blood levels of glucose. However, increasing evidence points towards other sites of action that might also have an important role, including the gastrointestinal …
Early evidence highlighted the liver as the major organ involved in the effect of metformin on reducing blood levels of glucose …
Metformin: historical overview.
Bailey CJ. Bailey CJ. Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3. Diabetologia. 2017. PMID: 28776081
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also known as goat's rue), a traditional herbal medicine in Europe, found to be rich in …
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 di …
Metformin: clinical use in type 2 diabetes.
Sanchez-Rangel E, Inzucchi SE. Sanchez-Rangel E, et al. Diabetologia. 2017 Sep;60(9):1586-1593. doi: 10.1007/s00125-017-4336-x. Epub 2017 Aug 2. Diabetologia. 2017. PMID: 28770321 Review.
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patients with type 2 diabetes mellitus. ...Other benefits have also been described, including improvements in certain lipids, inflammatory marker …
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patie …
Clinical pharmacokinetics of metformin.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM. Graham GG, et al. Clin Pharmacokinet. 2011 Feb;50(2):81-98. doi: 10.2165/11534750-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241070 Review.
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, a guanidine derivative found in Galega officinalis (French lilac). ...An intron variant of OCT1 (single nucleotide polymorphism [SNP] rs622342) has been assoc …
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide developed from galegine, a guanidine deriva …
A review of phenformin, metformin, and imeglimin.
Yendapally R, Sikazwe D, Kim SS, Ramsinghani S, Fraser-Spears R, Witte AP, La-Viola B. Yendapally R, et al. Drug Dev Res. 2020 Jun;81(4):390-401. doi: 10.1002/ddr.21636. Epub 2020 Jan 9. Drug Dev Res. 2020. PMID: 31916629 Review.
Diabetes mellitus is a serious metabolic disorder affecting millions of people worldwide. Phenformin and metformin are biguanide antidiabetic agents that are conveniently synthesized in a single-step chemical reaction. Phenformin was once used to lower blood …
Diabetes mellitus is a serious metabolic disorder affecting millions of people worldwide. Phenformin and metformin are biguanide anti …
Metformin: new applications for an old drug.
Naseri A, Sanaie S, Hamzehzadeh S, Seyedi-Sahebari S, Hosseini MS, Gholipour-Khalili E, Rezazadeh-Gavgani E, Majidazar R, Seraji P, Daneshvar S, Rezazadeh-Gavgani E. Naseri A, et al. J Basic Clin Physiol Pharmacol. 2022 Dec 7;34(2):151-160. doi: 10.1515/jbcpp-2022-0252. eCollection 2023 Mar 1. J Basic Clin Physiol Pharmacol. 2022. PMID: 36474458 Review.
Metformin is a biguanide, evolved as one of the most widely used medicines. The applications of this component include but are not limited to reducing blood glucose, weight loss, and polycystic ovary syndrome. ...There is evidence of the beneficial effects of …
Metformin is a biguanide, evolved as one of the most widely used medicines. The applications of this component include but are not li …
Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice.
Nishiyama K, Ono M, Tsuno T, Inoue R, Fukunaka A, Okuyama T, Kyohara M, Togashi Y, Fukushima S, Atsumi T, Sato A, Tsurumoto A, Sakai C, Fujitani Y, Terauchi Y, Ito S, Shirakawa J. Nishiyama K, et al. Endocrinology. 2023 Jun 26;164(8):bqad095. doi: 10.1210/endocr/bqad095. Endocrinology. 2023. PMID: 37314160
Imeglimin, metformin, or Imeg + Met treatment had no significant effects on glucose tolerance, insulin sensitivity, respiratory exchange ratio, or locomotor activity in db/db mice. The responsiveness of insulin secretion to glucose was recovered by Imeg + Met treatm …
Imeglimin, metformin, or Imeg + Met treatment had no significant effects on glucose tolerance, insulin sensitivity, respiratory excha …
The Metformin Paradox.
Weijers RNM, Bekedam DJ. Weijers RNM, et al. Curr Diabetes Rev. 2020;16(2):143-147. doi: 10.2174/1573399814666181119145750. Curr Diabetes Rev. 2020. PMID: 30451115 Review.
This deficiency lowers membrane flexibility, which in turn, reduces the amount of all functional Class I glucose transporters, and thereby reduces glucose-mediated ATP production. This leads to an increase in essentially saturated free fatty acid (FFA) levels for fa …
This deficiency lowers membrane flexibility, which in turn, reduces the amount of all functional Class I glucose transporters, and th …
Dorzagliatin: First Approval.
Syed YY. Syed YY. Drugs. 2022 Dec;82(18):1745-1750. doi: 10.1007/s40265-022-01813-0. Drugs. 2022. PMID: 36449148 Review.
Dorzagliatin improves glycaemic control by activating pancreatic and hepatic glucokinase in a glucose-dependent manner. In September 2022, dorzagliatin (with diet control and exercise) as monotherapy and as an add-on to metformin (when glycaemic control is inadequate with …
Dorzagliatin improves glycaemic control by activating pancreatic and hepatic glucokinase in a glucose-dependent manner. In September …
428,128 results
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