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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1834 1
1883 1
1910 1
1915 1
1916 1
1918 1
1931 1
1932 1
1937 1
1938 1
1939 1
1940 3
1941 3
1942 2
1943 2
1944 1
1945 4
1946 14
1947 26
1948 34
1949 43
1950 35
1951 49
1952 92
1953 61
1954 65
1955 91
1956 87
1957 86
1958 69
1959 81
1960 100
1961 86
1962 92
1963 150
1964 210
1965 187
1966 206
1967 222
1968 239
1969 263
1970 240
1971 264
1972 280
1973 319
1974 391
1975 676
1976 739
1977 737
1978 687
1979 850
1980 767
1981 827
1982 816
1983 981
1984 1022
1985 1096
1986 1048
1987 1175
1988 1225
1989 1511
1990 1676
1991 1810
1992 1928
1993 2027
1994 2247
1995 2280
1996 2477
1997 2922
1998 3055
1999 3285
2000 3405
2001 3690
2002 3976
2003 4320
2004 4851
2005 5423
2006 6037
2007 6253
2008 6787
2009 7174
2010 7846
2011 8452
2012 9163
2013 9988
2014 10926
2015 11954
2016 12116
2017 12806
2018 14036
2019 14586
2020 16356
2021 17954
2022 18156
2023 17128
2024 6280

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251,143 results

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Page 1
Hyperuricemia and Cardiovascular Disease.
Zhang S, Wang Y, Cheng J, Huangfu N, Zhao R, Xu Z, Zhang F, Zheng W, Zhang D. Zhang S, et al. Curr Pharm Des. 2019;25(6):700-709. doi: 10.2174/1381612825666190408122557. Curr Pharm Des. 2019. PMID: 30961478 Review.
Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney …
Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the developme …
Asymptomatic hyperuricemia: is it really asymptomatic?
Yip K, Cohen RE, Pillinger MH. Yip K, et al. Curr Opin Rheumatol. 2020 Jan;32(1):71-79. doi: 10.1097/BOR.0000000000000679. Curr Opin Rheumatol. 2020. PMID: 31688126 Review.
However, the significance of asymptomatic hyperuricemia - hyperuricemia in the absence of gout - continues to be debated. ...SUMMARY: Accumulating evidence suggests that asymptomatic hyperuricemia contributes to the comorbidities with which it associates and …
However, the significance of asymptomatic hyperuricemia - hyperuricemia in the absence of gout - continues to be debated. ...S …
Mouse models for human hyperuricaemia: a critical review.
Lu J, Dalbeth N, Yin H, Li C, Merriman TR, Wei WH. Lu J, et al. Nat Rev Rheumatol. 2019 Jul;15(7):413-426. doi: 10.1038/s41584-019-0222-x. Nat Rev Rheumatol. 2019. PMID: 31118497 Review.
This Review provides an overview of the mouse models of hyperuricaemia and the relevance of these models to human hyperuricaemia, with an emphasis on those models generated through genetic modifications. The challenges in developing and comparing mouse models of …
This Review provides an overview of the mouse models of hyperuricaemia and the relevance of these models to human hyperuricaemia …
An update on the genetics of hyperuricaemia and gout.
Major TJ, Dalbeth N, Stahl EA, Merriman TR. Major TJ, et al. Nat Rev Rheumatol. 2018 Jun;14(6):341-353. doi: 10.1038/s41584-018-0004-x. Nat Rev Rheumatol. 2018. PMID: 29740155 Review.
Mendelian randomization studies using urate-associated genetic variants as unconfounded surrogates for lifelong urate exposure have not supported claims that urate is causal for metabolic conditions that are comorbidities of hyperuricaemia and gout. Genetic studies have al …
Mendelian randomization studies using urate-associated genetic variants as unconfounded surrogates for lifelong urate exposure have not supp …
Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease.
Borghi C, Agabiti-Rosei E, Johnson RJ, Kielstein JT, Lurbe E, Mancia G, Redon J, Stack AG, Tsioufis KP. Borghi C, et al. Eur J Intern Med. 2020 Oct;80:1-11. doi: 10.1016/j.ejim.2020.07.006. Epub 2020 Jul 29. Eur J Intern Med. 2020. PMID: 32739239 Review.
During the last century, there has been an increasing prevalence of hyperuricaemia noted in many populations. While uric acid is usually discussed in the context of gout, hyperuricaemia is also associated with hypertension, chronic kidney disease, hypertriglyceridae …
During the last century, there has been an increasing prevalence of hyperuricaemia noted in many populations. While uric acid is usua …
Asymptomatic hyperuricaemia: a silent activator of the innate immune system.
Joosten LAB, Crişan TO, Bjornstad P, Johnson RJ. Joosten LAB, et al. Nat Rev Rheumatol. 2020 Feb;16(2):75-86. doi: 10.1038/s41584-019-0334-3. Epub 2019 Dec 10. Nat Rev Rheumatol. 2020. PMID: 31822862 Free PMC article. Review.
Asymptomatic hyperuricaemia affects ~20% of the general population in the USA, with variable rates in other countries. ...This Review summarizes what is known about the role of urate in the inflammatory response. Further research is needed to define the role of asym …
Asymptomatic hyperuricaemia affects ~20% of the general population in the USA, with variable rates in other countries. ...This Review …
Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options.
Bardin T, Richette P. Bardin T, et al. BMC Med. 2017 Jul 3;15(1):123. doi: 10.1186/s12916-017-0890-9. BMC Med. 2017. PMID: 28669352 Free PMC article. Review.
Numerous epidemiological studies have shown the association of asymptomatic hyperuricaemia with the above-mentioned diseases and cardiovascular risk factors. ...Thus, large randomised placebo-controlled trials are still needed to assess the benefits of treating asymptomati …
Numerous epidemiological studies have shown the association of asymptomatic hyperuricaemia with the above-mentioned diseases and card …
Hyperuricemia and gout.
Lioté F. Lioté F. Curr Rheumatol Rep. 2003 Jun;5(3):227-34. doi: 10.1007/s11926-003-0072-y. Curr Rheumatol Rep. 2003. PMID: 12744816 Review.
This review of the literature will focus on new insights on the pathogenesis of idiopathic hyperuricemia, and on secondary hyperuricemia and gout. There are also important advances on the pathophysiology of acute gout, especially as a self-limited process (switch fr …
This review of the literature will focus on new insights on the pathogenesis of idiopathic hyperuricemia, and on secondary hyperur …
Mechanisms and rationale for uricase use in patients with gout.
Schlesinger N, Pérez-Ruiz F, Lioté F. Schlesinger N, et al. Nat Rev Rheumatol. 2023 Oct;19(10):640-649. doi: 10.1038/s41584-023-01006-3. Epub 2023 Sep 8. Nat Rev Rheumatol. 2023. PMID: 37684360 Review.
Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay urate-lowering therapy (ULT) for treating hyperuricaemia in patients with gout. However, not all patients receiving oral ULT achieve the target serum urate level, in part because some pat …
Xanthine oxidase inhibitors such as allopurinol and febuxostat have been the mainstay urate-lowering therapy (ULT) for treating hyperuric …
Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial.
Doehner W, Anker SD, Butler J, Zannad F, Filippatos G, Ferreira JP, Salsali A, Kaempfer C, Brueckmann M, Pocock SJ, Januzzi JL, Packer M. Doehner W, et al. Eur Heart J. 2022 Sep 21;43(36):3435-3446. doi: 10.1093/eurheartj/ehac320. Eur Heart J. 2022. PMID: 35788657 Free PMC article. Clinical Trial.
RESULTS: Hyperuricaemia was prevalent in 53% of patients with no sex differences. ...Empagliflozin induced a rapid and sustained reduction of SUA levels and of clinical events related to hyperuricaemia. The benefit of empagliflozin on the primary outcome was observe …
RESULTS: Hyperuricaemia was prevalent in 53% of patients with no sex differences. ...Empagliflozin induced a rapid and sustained redu …
251,143 results
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