Tag Team Ubiquitin Ligases

Gary Kleiger; Raymond Deshaies

doi:10.1016/j.cell.2016.08.014

Tag Team Ubiquitin Ligases

Cell. 2016 Aug 25;166(5):1080-1081. doi: 10.1016/j.cell.2016.08.014.

Authors

Gary Kleiger¹, Raymond Deshaies²

Affiliations

¹ Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, 4505 South Maryland Parkway, Las Vegas, NV 89154, USA.
² Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Blvd, Pasadena, CA 91125, USA; Howard Hughes Medical Institute. Electronic address: deshaies@caltech.edu.

PMID: 27565338
DOI: 10.1016/j.cell.2016.08.014

Abstract

Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.

Publication types

Comment

MeSH terms

Cullin Proteins
Humans
Ubiquitin*
Ubiquitin-Protein Ligases*

Substances

Cullin Proteins
Ubiquitin
Ubiquitin-Protein Ligases

Grants and funding

R01 GM065997/GM/NIGMS NIH HHS/United States