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Morphological profiling of small molecules.
Ziegler S, Sievers S, Waldmann H. Ziegler S, et al. Cell Chem Biol. 2021 Mar 18;28(3):300-319. doi: 10.1016/j.chembiol.2021.02.012. Cell Chem Biol. 2021. PMID: 33740434 Free article. Review.
Profiling approaches such as gene expression or proteome profiling generate small-molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased manner and have become indispensable tools in the evaluation of bioactive small molec …
Profiling approaches such as gene expression or proteome profiling generate small-molecule bioactivity profiles that de …
Morphological subprofile analysis for bioactivity annotation of small molecules.
Pahl A, Schölermann B, Lampe P, Rusch M, Dow M, Hedberg C, Nelson A, Sievers S, Waldmann H, Ziegler S. Pahl A, et al. Cell Chem Biol. 2023 Jul 20;30(7):839-853.e7. doi: 10.1016/j.chembiol.2023.06.003. Epub 2023 Jun 28. Cell Chem Biol. 2023. PMID: 37385259
Fast prediction of the mode of action (MoA) for bioactive compounds would immensely foster bioactivity annotation in compound collections and may early on reveal off-targets in chemical biology research and drug discovery. Morphological profiling, e.g., using the Ce …
Fast prediction of the mode of action (MoA) for bioactive compounds would immensely foster bioactivity annotation in compound collections an …