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Results: 1 to 20 of 250

1.

The lumped constant for the galactose analog 2-18F-fluoro-2-deoxy-D-galactose is increased in patients with parenchymal liver disease.

Mikkelsen KS, Sørensen M, Frisch K, Villadsen GE, Bibby BM, Keiding S.

J Nucl Med. 2014 Apr;55(4):590-4. doi: 10.2967/jnumed.113.125559. Epub 2014 Mar 3.

PMID:
24591487
[PubMed - indexed for MEDLINE]
2.

Homozygosity mapping identifies a GALK1 mutation as the cause of autosomal recessive congenital cataracts in 4 adult siblings.

Chacon-Camacho OF, Buentello-Volante B, Velázquez-Montoya R, Ayala-Ramirez R, Zenteno JC.

Gene. 2014 Jan 25;534(2):218-21. doi: 10.1016/j.gene.2013.10.057. Epub 2013 Nov 7.

PMID:
24211322
[PubMed - indexed for MEDLINE]
3.

Survival of primary human hepatocytes and death of induced pluripotent stem cells in media lacking glucose and arginine.

Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.

PLoS One. 2013 Aug 14;8(8):e71897. doi: 10.1371/journal.pone.0071897. eCollection 2013.

PMID:
23967260
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Role of Arg228 in the phosphorylation of galactokinase: the mechanism of GHMP kinases by quantum mechanics/molecular mechanics studies.

Huang M, Li X, Zou JW, Timson DJ.

Biochemistry. 2013 Jul 16;52(28):4858-68. doi: 10.1021/bi400228e. Epub 2013 Jul 1.

PMID:
23786354
[PubMed - indexed for MEDLINE]
5.

Static and dynamic interactions between GALK enzyme and known inhibitors: guidelines to design new drugs for galactosemic patients.

Chiappori F, Merelli I, Milanesi L, Marabotti A.

Eur J Med Chem. 2013 May;63:423-34. doi: 10.1016/j.ejmech.2013.02.021. Epub 2013 Feb 27.

PMID:
23517731
[PubMed - indexed for MEDLINE]
6.

Chemoenzymatic synthesis of mono- and di-fluorinated Thomsen-Friedenreich (T) antigens and their sialylated derivatives.

Yan J, Chen X, Wang F, Cao H.

Org Biomol Chem. 2013 Feb 7;11(5):842-8. doi: 10.1039/c2ob26989a. Epub 2012 Dec 14.

PMID:
23241945
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Galactokinase deficiency induced cataracts in Indian infants: identification of 4 novel mutations in GALK gene.

Singh R, Ram J, Kaur G, Prasad R.

Curr Eye Res. 2012 Oct;37(10):949-54. doi: 10.3109/02713683.2012.688162. Epub 2012 May 25.

PMID:
22632133
[PubMed - indexed for MEDLINE]
8.

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.

Lavy T, Kumar PR, He H, Joshua-Tor L.

Genes Dev. 2012 Feb 1;26(3):294-303. doi: 10.1101/gad.182691.111.

PMID:
22302941
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Evaluation of analogues of GalNAc as substrates for enzymes of the mammalian GalNAc salvage pathway.

Pouilly S, Bourgeaux V, Piller F, Piller V.

ACS Chem Biol. 2012 Apr 20;7(4):753-60. doi: 10.1021/cb200511t. Epub 2012 Feb 9.

PMID:
22276930
[PubMed - indexed for MEDLINE]
10.

Early cataract formation due to galactokinase deficiency: impact of newborn screening.

Janzen N, Illsinger S, Meyer U, Shin YS, Sander J, Lücke T, Das AM.

Arch Med Res. 2011 Oct;42(7):608-12. doi: 10.1016/j.arcmed.2011.11.004. Epub 2011 Dec 5.

PMID:
22154682
[PubMed - indexed for MEDLINE]
11.

Innovative therapy for Classic Galactosemia - tale of two HTS.

Tang M, Odejinmi SI, Vankayalapati H, Wierenga KJ, Lai K.

Mol Genet Metab. 2012 Jan;105(1):44-55. doi: 10.1016/j.ymgme.2011.09.028. Epub 2011 Oct 1. Review.

PMID:
22018723
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

N-acetylgalactosamine kinase: a naturally promiscuous small molecule kinase.

Kristiansson H, Timson DJ.

Appl Biochem Biotechnol. 2012 Jan;166(1):57-63. doi: 10.1007/s12010-011-9403-z. Epub 2011 Oct 8.

PMID:
21984386
[PubMed - indexed for MEDLINE]
13.

Hepatic galactose metabolism quantified in humans using 2-18F-fluoro-2-deoxy-D-galactose PET/CT.

Sørensen M, Mikkelsen KS, Frisch K, Bass L, Bibby BM, Keiding S.

J Nucl Med. 2011 Oct;52(10):1566-72. doi: 10.2967/jnumed.111.092924. Epub 2011 Aug 29.

PMID:
21875925
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Increased promiscuity of human galactokinase following alteration of a single amino acid residue distant from the active site.

Kristiansson H, Timson DJ.

Chembiochem. 2011 Sep 5;12(13):2081-7. doi: 10.1002/cbic.201100308. Epub 2011 Jul 11.

PMID:
21748839
[PubMed - indexed for MEDLINE]
15.

The role of the active site residues in human galactokinase: implications for the mechanisms of GHMP kinases.

Megarity CF, Huang M, Warnock C, Timson DJ.

Bioorg Chem. 2011 Jun;39(3):120-6. doi: 10.1016/j.bioorg.2011.03.001. Epub 2011 Mar 21.

PMID:
21474160
[PubMed - indexed for MEDLINE]
16.

Features and outcome of galactokinase deficiency in children diagnosed by newborn screening.

Hennermann JB, Schadewaldt P, Vetter B, Shin YS, Mönch E, Klein J.

J Inherit Metab Dis. 2011 Apr;34(2):399-407. doi: 10.1007/s10545-010-9270-8. Epub 2011 Feb 3.

PMID:
21290184
[PubMed - indexed for MEDLINE]
17.

The effect of a Pro²⁸Thr point mutation on the local structure and stability of human galactokinase enzyme-a theoretical study.

Jójárt B, Szori M, Izsák R, Marsi I, László A, Csizmadia IG, Viskolcz B.

J Mol Model. 2011 Oct;17(10):2639-49. doi: 10.1007/s00894-011-0958-y. Epub 2011 Jan 25.

PMID:
21264483
[PubMed - indexed for MEDLINE]
18.

Ultra fast and sensitive liquid chromatography tandem mass spectrometry based assay for galactose-1-phosphate uridylyltransferase and galactokinase deficiencies.

Li Y, Ptolemy AS, Harmonay L, Kellogg M, Berry GT.

Mol Genet Metab. 2011 Jan;102(1):33-40. doi: 10.1016/j.ymgme.2010.08.018. Epub 2010 Sep 21.

PMID:
20863731
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Generalized epimerase deficiency galactosemia.

Sarkar M, Bose SS, Mondal G, Chatterjee S.

Indian J Pediatr. 2010 Aug;77(8):909-10. doi: 10.1007/s12098-010-0135-9. Epub 2010 Aug 20.

PMID:
20725869
[PubMed - indexed for MEDLINE]
20.

Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors.

Tang M, Wierenga K, Elsas LJ, Lai K.

Chem Biol Interact. 2010 Dec 5;188(3):376-85. doi: 10.1016/j.cbi.2010.07.025. Epub 2010 Aug 7.

PMID:
20696150
[PubMed - indexed for MEDLINE]
Free PMC Article

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