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Results: 1 to 20 of 42

1.

Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study.

Etienne-Grimaldi MC, Mahamat A, Chazal M, Laurent-Puig P, Olschwang S, Gaub MP, Formento JL, Formento P, Sudaka A, Boige V, Abderrahim-Ferkoune A, Benchimol D, André T, Houry S, Faucheron JL, Letoublon C, Gilly FN, Delpero JR, Lasser P, Pradere B, Pezet D, Penault-Llorca F, Milano G.

Br J Cancer. 2014 May 27;110(11):2728-37. doi: 10.1038/bjc.2014.213. Epub 2014 May 6.

PMID:
24800948
[PubMed - indexed for MEDLINE]
2.

Molecular basis of 5-fluorouracil-related toxicity: lessons from clinical practice.

Papanastasopoulos P, Stebbing J.

Anticancer Res. 2014 Apr;34(4):1531-5. Review.

PMID:
24692679
[PubMed - indexed for MEDLINE]
3.

Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activity.

Offer SM, Fossum CC, Wegner NJ, Stuflesser AJ, Butterfield GL, Diasio RB.

Cancer Res. 2014 May 1;74(9):2545-54. doi: 10.1158/0008-5472.CAN-13-2482. Epub 2014 Mar 19.

PMID:
24648345
[PubMed - indexed for MEDLINE]
4.

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.

Rosmarin D, Palles C, Church D, Domingo E, Jones A, Johnstone E, Wang H, Love S, Julier P, Scudder C, Nicholson G, Gonzalez-Neira A, Martin M, Sargent D, Green E, McLeod H, Zanger UM, Schwab M, Braun M, Seymour M, Thompson L, Lacas B, Boige V, Ribelles N, Afzal S, Enghusen H, Jensen SA, Etienne-Grimaldi MC, Milano G, Wadelius M, Glimelius B, Garmo H, Gusella M, Lecomte T, Laurent-Puig P, Martinez-Balibrea E, Sharma R, Garcia-Foncillas J, Kleibl Z, Morel A, Pignon JP, Midgley R, Kerr D, Tomlinson I.

J Clin Oncol. 2014 Apr 1;32(10):1031-9. doi: 10.1200/JCO.2013.51.1857. Epub 2014 Mar 3. Review.

PMID:
24590654
[PubMed - indexed for MEDLINE]
5.

DPYD, TYMS, TYMP, TK1, and TK2 genetic expressions as response markers in locally advanced rectal cancer patients treated with fluoropyrimidine-based chemoradiotherapy.

Huang MY, Wu CH, Huang CM, Chung FY, Huang CW, Tsai HL, Chen CF, Lin SR, Wang JY.

Biomed Res Int. 2013;2013:931028. doi: 10.1155/2013/931028. Epub 2013 Dec 23.

PMID:
24455740
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxic effects: potential for an individualized medicine approach.

Saif MW, Lee AM, Offer SM, McConnell K, Relias V, Diasio RB.

Mayo Clin Proc. 2014 Jan;89(1):131-6. doi: 10.1016/j.mayocp.2013.09.008.

PMID:
24388031
[PubMed - indexed for MEDLINE]
7.

Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro.

Deng J, Lei W, Fu JC, Zhang L, Li JH, Xiong JP.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):789-95. doi: 10.1016/j.bbrc.2013.11.064. Epub 2013 Nov 23.

PMID:
24275137
[PubMed - indexed for MEDLINE]
8.

Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines.

Jennings BA, Loke YK, Skinner J, Keane M, Chu GS, Turner R, Epurescu D, Barrett A, Willis G.

PLoS One. 2013 Oct 22;8(10):e78053. doi: 10.1371/journal.pone.0078053. eCollection 2013.

PMID:
24167597
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer.

Ide H, Kikuchi E, Hasegawa M, Hattori S, Yasumizu Y, Miyajima A, Oya M.

Cancer Med. 2013 Aug;2(4):488-95. doi: 10.1002/cam4.95. Epub 2013 Jun 10.

PMID:
24156021
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers.

Gross E, Meul C, Raab S, Propping C, Avril S, Aubele M, Gkazepis A, Schuster T, Grebenchtchikov N, Schmitt M, Kiechle M, Meijer J, Vijzelaar R, Meindl A, van Kuilenburg AB.

Br J Cancer. 2013 Oct 29;109(9):2347-55. doi: 10.1038/bjc.2013.621. Epub 2013 Oct 8.

PMID:
24104963
[PubMed - indexed for MEDLINE]
11.

(13)C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients.

Cunha-Junior GF, De Marco L, Bastos-Rodrigues L, Bolina MB, Martins FL, Pianetti GA, Cesar IC, Coelho LG.

Cancer Chemother Pharmacol. 2013 Dec;72(6):1273-82. doi: 10.1007/s00280-013-2309-4. Epub 2013 Oct 8.

PMID:
24101147
[PubMed - indexed for MEDLINE]
12.

Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.

Mekata E, Murata S, Sonoda H, Shimizu T, Umeda T, Shiomi H, Naka S, Yamamoto H, Abe H, Edamatsu T, Fujieda A, Fujioka M, Wada T, Tani T.

Oncol Rep. 2013 Dec;30(6):2845-51. doi: 10.3892/or.2013.2788. Epub 2013 Oct 4.

PMID:
24100378
[PubMed - indexed for MEDLINE]
13.

Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer.

Alcazar-González GA, Calderón-Garcidueñas AL, Garza-Rodríguez ML, Rubio-Hernández G, Escorza-Treviño S, Olano-Martin E, Cerda-Flores RM, Castruita-Avila AL, González-Guerrero JF, le Brun S, Simon-Buela L, Barrera-Saldaña HA.

Pharmacogenomics. 2013 Oct;14(13):1583-92. doi: 10.2217/pgs.13.83.

PMID:
24088129
[PubMed - indexed for MEDLINE]
14.

Detection of complete dihydropyrimidine dehydrogenase deficiency in a Tunisian family using a simple phenotypic test.

Mani A, Nouira M, Ahmed SB, Saguem S.

Indian J Pharmacol. 2013 Jul-Aug;45(4):414-5. doi: 10.4103/0253-7613.115010. No abstract available.

PMID:
24014927
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Genome-wide copy number variation in sporadic amyotrophic lateral sclerosis in the Turkish population: deletion of EPHA3 is a possible protective factor.

Uyan Ö, Ömür Ö, Ağım ZS, Özoğuz A, Li H, Parman Y, Deymeer F, Oflazer P, Koç F, Tan E, Özçelik H, Başak AN.

PLoS One. 2013 Aug 26;8(8):e72381. doi: 10.1371/journal.pone.0072381. eCollection 2013.

PMID:
23991104
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing.

Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M.

Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29.

PMID:
23988873
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Screening of dihydropyrimidine dehydrogenase genetic variants by direct sequencing in different ethnic groups.

Shin JG, Cheong HS, Kim JY, Kim LH, Han CS, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD.

J Korean Med Sci. 2013 Aug;28(8):1129-33. doi: 10.3346/jkms.2013.28.8.1129. Epub 2013 Jul 31.

PMID:
23960437
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients.

Teh LK, Hamzah S, Hashim H, Bannur Z, Zakaria ZA, Hasbullani Z, Shia JK, Fijeraid H, Md Nor A, Zailani M, Ramasamy P, Ngow H, Sood S, Salleh MZ.

Ther Drug Monit. 2013 Oct;35(5):624-30. doi: 10.1097/FTD.0b013e318290acd2.

PMID:
23942539
[PubMed - indexed for MEDLINE]
19.

DPYD IVS14+1G>A and 2846A>T genotyping for the prediction of severe fluoropyrimidine-related toxicity: a meta-analysis.

Terrazzino S, Cargnin S, Del Re M, Danesi R, Canonico PL, Genazzani AA.

Pharmacogenomics. 2013 Aug;14(11):1255-72. doi: 10.2217/pgs.13.116.

PMID:
23930673
[PubMed - indexed for MEDLINE]
20.

Impact of excision repair cross-complementing gene 1 (ERCC1) on the outcomes of patients with advanced gastric cancer: correlative study in Japan Clinical Oncology Group Trial JCOG9912.

Yamada Y, Boku N, Nishina T, Yamaguchi K, Denda T, Tsuji A, Hamamoto Y, Konishi K, Tsuji Y, Amagai K, Ohkawa S, Fujita Y, Nishisaki H, Kawai H, Takashima A, Mizusawa J, Nakamura K, Ohtsu A.

Ann Oncol. 2013 Oct;24(10):2560-5. doi: 10.1093/annonc/mdt238. Epub 2013 Jul 24.

PMID:
23884439
[PubMed - indexed for MEDLINE]

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