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CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans.
Waaijers S, Portegijs V, Kerver J, Lemmens BB, Tijsterman M, van den Heuvel S, Boxem M. Waaijers S, et al. Genetics. 2013 Nov;195(3):1187-91. doi: 10.1534/genetics.113.156299. Epub 2013 Aug 26. Genetics. 2013. PMID: 23979586 Free PMC article.
The generation of genetic mutants in Caenorhabditis elegans has long relied on the selection of mutations in large-scale screens. Directed mutagenesis of specific loci in the genome would greatly speed up analysis of gene function. ...
The generation of genetic mutants in Caenorhabditis elegans has long relied on the selection of mutations in large-scale screens. Directed …
DREAM interrupted: severing LIN-35-MuvB association in Caenorhabditis elegans impairs DREAM function but not its chromatin localization.
Goetsch PD, Strome S. Goetsch PD, et al. Genetics. 2022 Jul 4;221(3):iyac073. doi: 10.1093/genetics/iyac073. Genetics. 2022. PMID: 35554539 Free PMC article.
Here, we examined how the Rb-like pocket protein contributes to DREAM formation and function by disrupting the interaction between the sole Caenorhabditis elegans pocket protein LIN-35 and the MuvB subunit LIN-52 using CRISPR/Cas9 targeted mutagenesis. …
Here, we examined how the Rb-like pocket protein contributes to DREAM formation and function by disrupting the interaction between the sole …