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Page 1
Biocatalysts by evolution.
Jäckel C, Hilvert D. Jäckel C, et al. Curr Opin Biotechnol. 2010 Dec;21(6):753-9. doi: 10.1016/j.copbio.2010.08.008. Epub 2010 Sep 17. Curr Opin Biotechnol. 2010. PMID: 20850962 Review.
Analogous evolutionary strategies are being profitably exploited in the laboratory to generate and optimize biocatalysts for diverse biotechnological applications. In this review, we summarize recent efforts to improve this process by creating more effective protein librar …
Analogous evolutionary strategies are being profitably exploited in the laboratory to generate and optimize biocatalysts for diverse …
Directed evolution of carbon-hydrogen bond activating enzymes.
Frey R, Hayashi T, Buller RM. Frey R, et al. Curr Opin Biotechnol. 2019 Dec;60:29-38. doi: 10.1016/j.copbio.2018.12.004. Epub 2018 Dec 21. Curr Opin Biotechnol. 2019. PMID: 30583278 Review.
Especially the utilization of carbon-hydrogen bond (C-H) activating enzymes is very attractive as they catalyze a variety of chemically extremely challenging transformations. ...Looking forward, the use of automation and advanced computer algorithms will help to streamline …
Especially the utilization of carbon-hydrogen bond (C-H) activating enzymes is very attractive as they catalyze a variety of chemical …
Emerging chemicals and the evolution of biodegradation capacities and pathways in bacteria.
Kolvenbach BA, Helbling DE, Kohler HP, Corvini PF. Kolvenbach BA, et al. Curr Opin Biotechnol. 2014 Jun;27:8-14. doi: 10.1016/j.copbio.2013.08.017. Epub 2013 Sep 17. Curr Opin Biotechnol. 2014. PMID: 24863891 Review.
Current research provides an understanding of how the evolution of promiscuous enzymes and the recruitment of enzymes available from the metagenome allows for the assembly of these pathways. ...
Current research provides an understanding of how the evolution of promiscuous enzymes and the recruitment of enzymes availabl …
Droplet-based microfluidics and enzyme evolution.
Jain A, Stavrakis S, deMello A. Jain A, et al. Curr Opin Biotechnol. 2024 Mar 1;87:103097. doi: 10.1016/j.copbio.2024.103097. Online ahead of print. Curr Opin Biotechnol. 2024. PMID: 38430713 Free article. Review.
Enzymes are widely used as catalysts in the chemical and pharmaceutical industries. While successful in many situations, they must usually be adapted to operate efficiently under nonnatural conditions. Enzyme engineering allows the creation of novel enzymes that are …
Enzymes are widely used as catalysts in the chemical and pharmaceutical industries. While successful in many situations, they must us …
Enzyme evolution for industrial biocatalytic cascades.
Nazor J, Liu J, Huisman G. Nazor J, et al. Curr Opin Biotechnol. 2021 Jun;69:182-190. doi: 10.1016/j.copbio.2020.12.013. Epub 2021 Jan 28. Curr Opin Biotechnol. 2021. PMID: 33517157 Review.
Multi-step, biocatalytic cascades are poised to lead to further adoption of enzymes by the chemical industry. Over the past twenty years, the promise of in vitro enzyme evolution for the sustainable biocatalytic synthesis of complex chemicals at large scale has materialize …
Multi-step, biocatalytic cascades are poised to lead to further adoption of enzymes by the chemical industry. Over the past twenty ye …
Directed enzyme evolution.
Farinas ET, Bulter T, Arnold FH. Farinas ET, et al. Curr Opin Biotechnol. 2001 Dec;12(6):545-51. doi: 10.1016/s0958-1669(01)00261-0. Curr Opin Biotechnol. 2001. PMID: 11849936 Review.
Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. ...
Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include …
Beyond directed evolution--semi-rational protein engineering and design.
Lutz S. Lutz S. Curr Opin Biotechnol. 2010 Dec;21(6):734-43. doi: 10.1016/j.copbio.2010.08.011. Epub 2010 Sep 24. Curr Opin Biotechnol. 2010. PMID: 20869867 Free PMC article. Review.
The advances in understanding protein structure and function, in no insignificant part a result of directed evolution studies, are increasingly empowering scientists and engineers to device more effective methods for manipulating and tailoring biocatalysts. Abandoning larg …
The advances in understanding protein structure and function, in no insignificant part a result of directed evolution studies, are increasin …
Metabolic engineering and directed evolution for the production of pharmaceuticals.
Chartrain M, Salmon PM, Robinson DK, Buckland BC. Chartrain M, et al. Curr Opin Biotechnol. 2000 Apr;11(2):209-14. doi: 10.1016/s0958-1669(00)00081-1. Curr Opin Biotechnol. 2000. PMID: 10753771 Review.
The tools of metabolic and enzyme engineering have been well developed in academic laboratories and are now being applied for the optimization of biocatalysts used in the production of a wide range of pharmaceutically important molecules. ...The use of directed evolution h …
The tools of metabolic and enzyme engineering have been well developed in academic laboratories and are now being applied for the optimizati …
Directed evolution of enzymes and pathways for industrial biocatalysis.
Zhao H, Chockalingam K, Chen Z. Zhao H, et al. Curr Opin Biotechnol. 2002 Apr;13(2):104-10. doi: 10.1016/s0958-1669(02)00291-4. Curr Opin Biotechnol. 2002. PMID: 11950559 Review.
Directed evolution has become a powerful tool for developing enzyme and whole cell based biocatalysts. Significant recent advances include the creation of novel enzyme functions and the development of several new efficient directed evolution methods. The combination of dir …
Directed evolution has become a powerful tool for developing enzyme and whole cell based biocatalysts. Significant recent advances in …
Adaptive laboratory evolution--harnessing the power of biology for metabolic engineering.
Portnoy VA, Bezdan D, Zengler K. Portnoy VA, et al. Curr Opin Biotechnol. 2011 Aug;22(4):590-4. doi: 10.1016/j.copbio.2011.03.007. Epub 2011 Apr 14. Curr Opin Biotechnol. 2011. PMID: 21497080 Review.
In contrast to rational engineering strategies and directed modification of specific enzymes, ALE has the advantage of letting nonintuitive beneficial mutations occur in many different genes and regulatory regions in parallel. ...
In contrast to rational engineering strategies and directed modification of specific enzymes, ALE has the advantage of letting nonint …
21 results