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Results: 1 to 20 of 35

1.

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.

Cheng JC, Bai A, Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR Jr, Bielawska A, Norris JS, Liu X.

J Clin Invest. 2013 Oct 1;123(10):4344-58. doi: 10.1172/JCI64791. Epub 2013 Sep 16.

PMID:
24091326
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.

Morad SA, Levin JC, Tan SF, Fox TE, Feith DJ, Cabot MC.

Biochim Biophys Acta. 2013 Dec;1831(12):1657-64. doi: 10.1016/j.bbalip.2013.07.016. Epub 2013 Aug 9.

PMID:
23939396
[PubMed - indexed for MEDLINE]
3.

Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis.

Berndt N, Patel R, Yang H, Balasis ME, Sebti SM.

Cell Cycle. 2013 Jul 1;12(13):2024-32. doi: 10.4161/cc.25043. Epub 2013 Jun 6.

PMID:
23777806
[PubMed - indexed for MEDLINE]
4.

Molecular basis of acid ceramidase deficiency in a neonatal form of Farber disease: identification of the first large deletion in ASAH1 gene.

Alves MQ, Le Trionnaire E, Ribeiro I, Carpentier S, Harzer K, Levade T, Ribeiro MG.

Mol Genet Metab. 2013 Jul;109(3):276-81. doi: 10.1016/j.ymgme.2013.04.019. Epub 2013 May 4.

PMID:
23707712
[PubMed - indexed for MEDLINE]
5.

Systemic ceramide accumulation leads to severe and varied pathological consequences.

Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA.

EMBO Mol Med. 2013 Jun;5(6):827-42. doi: 10.1002/emmm.201202301. Epub 2013 May 16.

PMID:
23681708
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.

Simonaro CM, Sachot S, Ge Y, He X, Deangelis VA, Eliyahu E, Leong DJ, Sun HB, Mason JB, Haskins ME, Richardson DW, Schuchman EH.

PLoS One. 2013 Apr 26;8(4):e62715. doi: 10.1371/journal.pone.0062715. Print 2013.

PMID:
23638138
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.

Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, LaFlamme DJ, Reisdorph N, Kechris KJ, Bowler RP.

Am J Respir Cell Mol Biol. 2013 Aug;49(2):316-23. doi: 10.1165/rcmb.2012-0230OC.

PMID:
23590301
[PubMed - indexed for MEDLINE]
8.

Acid ceramidase (AC)--a key enzyme of sphingolipid metabolism--correlates with better prognosis in epithelial ovarian cancer.

Hanker LC, Karn T, Holtrich U, Gätje R, Rody A, Heinrich T, Ruckhäberle E, Engels K.

Int J Gynecol Pathol. 2013 May;32(3):249-57. doi: 10.1097/PGP.0b013e3182673982.

PMID:
23518908
[PubMed - indexed for MEDLINE]
9.

Acid ceramidase as a therapeutic target in metastatic prostate cancer.

Camacho L, Meca-Cortés O, Abad JL, García S, Rubio N, Díaz A, Celià-Terrassa T, Cingolani F, Bermudo R, Fernández PL, Blanco J, Delgado A, Casas J, Fabriàs G, Thomson TM.

J Lipid Res. 2013 May;54(5):1207-20. doi: 10.1194/jlr.M032375. Epub 2013 Feb 19.

PMID:
23423838
[PubMed - indexed for MEDLINE]
10.

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity.

Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D.

Sci Rep. 2013;3:1035. doi: 10.1038/srep01035. Epub 2013 Jan 8.

PMID:
23301156
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.

Morad SA, Messner MC, Levin JC, Abdelmageed N, Park H, Merrill AH Jr, Cabot MC.

Cancer Chemother Pharmacol. 2013 Mar;71(3):635-45. doi: 10.1007/s00280-012-2050-4. Epub 2012 Dec 21.

PMID:
23263160
[PubMed - indexed for MEDLINE]
12.

Acid ceramidase (ASAH1) represses steroidogenic factor 1-dependent gene transcription in H295R human adrenocortical cells by binding to the receptor.

Lucki NC, Li D, Bandyopadhyay S, Wang E, Merrill AH, Sewer MB.

Mol Cell Biol. 2012 Nov;32(21):4419-31. doi: 10.1128/MCB.00378-12. Epub 2012 Aug 27.

PMID:
22927646
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Spinal muscular atrophy associated with progressive myoclonic epilepsy is caused by mutations in ASAH1.

Zhou J, Tawk M, Tiziano FD, Veillet J, Bayes M, Nolent F, Garcia V, Servidei S, Bertini E, Castro-Giner F, Renda Y, Carpentier S, Andrieu-Abadie N, Gut I, Levade T, Topaloglu H, Melki J.

Am J Hum Genet. 2012 Jul 13;91(1):5-14. doi: 10.1016/j.ajhg.2012.05.001. Epub 2012 Jun 14.

PMID:
22703880
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.

Ramírez de Molina A, de la Cueva A, Machado-Pinilla R, Rodriguez-Fanjul V, Gomez del Pulgar T, Cebrian A, Perona R, Lacal JC.

Curr Cancer Drug Targets. 2012 Jul;12(6):617-24.

PMID:
22515519
[PubMed - indexed for MEDLINE]
15.

DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.

Haynes TA, Filippov V, Filippova M, Yang J, Zhang K, Duerksen-Hughes PJ.

Biochim Biophys Acta. 2012 Jul;1821(7):943-53. doi: 10.1016/j.bbalip.2012.02.002. Epub 2012 Feb 11.

PMID:
22349266
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.

Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X.

Int J Cancer. 2012 Nov 1;131(9):2034-43. doi: 10.1002/ijc.27480. Epub 2012 Mar 27.

PMID:
22322590
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression.

Lucki NC, Bandyopadhyay S, Wang E, Merrill AH, Sewer MB.

Mol Endocrinol. 2012 Feb;26(2):228-43. doi: 10.1210/me.2011-1150. Epub 2012 Jan 19.

PMID:
22261821
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.

Flowers M, Fabriás G, Delgado A, Casas J, Abad JL, Cabot MC.

Breast Cancer Res Treat. 2012 Jun;133(2):447-58. doi: 10.1007/s10549-011-1768-8. Epub 2011 Sep 21.

PMID:
21935601
[PubMed - indexed for MEDLINE]
19.

Novel V97G ASAH1 mutation found in Farber disease patients: unique appearance of the disease with an intermediate severity, and marked early involvement of central and peripheral nervous system.

Chedrawi AK, Al-Hassnan ZN, Al-Muhaizea M, Colak D, Al-Younes B, Albakheet A, Tulba S, Kaya N.

Brain Dev. 2012 May;34(5):400-4. doi: 10.1016/j.braindev.2011.07.003. Epub 2011 Sep 3.

PMID:
21893389
[PubMed - indexed for MEDLINE]
20.

Identification of cystatin SA as a novel inhibitor of acid ceramidase.

Eliyahu E, Shtraizent N, He X, Chen D, Shalgi R, Schuchman EH.

J Biol Chem. 2011 Oct 14;286(41):35624-33. doi: 10.1074/jbc.M111.260372. Epub 2011 Aug 16.

PMID:
21846728
[PubMed - indexed for MEDLINE]
Free PMC Article

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