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Peroxide Natural Products from Plakortis zyggompha and the Sponge Association Plakortis halichondrioides-Xestospongia deweerdtae: Antifungal Activity against Cryptococcus gattii.
Jamison MT, Dalisay DS, Molinski TF. Jamison MT, et al. J Nat Prod. 2016 Mar 25;79(3):555-63. doi: 10.1021/acs.jnatprod.5b00951. Epub 2016 Feb 9. J Nat Prod. 2016. PMID: 26859086
Investigation of antifungal extracts of the marine sponge association Plakortis halichondrioides-Xestospongia deweerdtae and the sponge Plakortis zyggompha from the Bahamas led to the discovery and isolation of 6-epi-7,8-dihydroplakortide K (1), plakortide AA (2), a …
Investigation of antifungal extracts of the marine sponge association Plakortis halichondrioides-Xestospongia deweerdtae and t …
Chemical constituents of the deep reef caribbean sponges Plakortis angulospiculatus and Plakortis halichondrioides and their anti-inflammatory activities.
Ankisetty S, Gochfeld DJ, Diaz MC, Khan SI, Slattery M. Ankisetty S, et al. J Nat Prod. 2010 Sep 24;73(9):1494-8. doi: 10.1021/np100233d. J Nat Prod. 2010. PMID: 20738102
Three new aromatic compounds (7-9) were isolated from the Caribbean sponge Plakortis halichondrioides. The structural determination of the compounds was based on extensive NMR and mass spectroscopic analysis. ...
Three new aromatic compounds (7-9) were isolated from the Caribbean sponge Plakortis halichondrioides. The structural determin …
Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation.
Schirmeister T, Oli S, Wu H, Della Sala G, Costantino V, Seo EJ, Efferth T. Schirmeister T, et al. Mar Drugs. 2017 Mar 3;15(3):63. doi: 10.3390/md15030063. Mar Drugs. 2017. PMID: 28273803 Free PMC article.
The 6-epimer of the plakortide H acid (1), along with the endoperoxides plakortide E (2), plakortin (3), and dihydroplakortin (4) have been isolated from a sample of the Caribbean sponge Plakortis halichondrioides. To perform a comparative study on the cytotoxicity …
The 6-epimer of the plakortide H acid (1), along with the endoperoxides plakortide E (2), plakortin (3), and dihydroplakortin (4) have been …
Polyketide synthases in the microbiome of the marine sponge Plakortis halichondrioides: a metagenomic update.
Della Sala G, Hochmuth T, Teta R, Costantino V, Mangoni A. Della Sala G, et al. Mar Drugs. 2014 Nov 14;12(11):5425-40. doi: 10.3390/md12115425. Mar Drugs. 2014. PMID: 25405856 Free PMC article.
A comprehensive overview of polyketide biosynthetic genes of the sponge Plakortis halichondrioides and its symbionts was obtained in the present study by massively parallel 454 pyrosequencing of complex and heterogeneous PCR (Polymerase Chain Reaction) products ampl …
A comprehensive overview of polyketide biosynthetic genes of the sponge Plakortis halichondrioides and its symbionts was obtai …
Identification of plakortide E from the Caribbean sponge Plakortis halichondroides as a trypanocidal protease inhibitor using bioactivity-guided fractionation.
Oli S, Abdelmohsen UR, Hentschel U, Schirmeister T. Oli S, et al. Mar Drugs. 2014 May 2;12(5):2614-22. doi: 10.3390/md12052614. Mar Drugs. 2014. PMID: 24798927 Free PMC article.
We further report on its anti-parasitic activity against Trypanosoma brucei with an IC50 value of 5 muM and without cytotoxic effects against J774.1 macrophages at 100 muM concentration. Plakortide E was isolated from the sponge Plakortis halichondroides using enzym …
We further report on its anti-parasitic activity against Trypanosoma brucei with an IC50 value of 5 muM and without cytotoxic effects agains …
Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides.
Jiménez-Romero C, Ortiz I, Vicente J, Vera B, Rodríguez AD, Nam S, Jove R. Jiménez-Romero C, et al. J Nat Prod. 2010 Oct 22;73(10):1694-700. doi: 10.1021/np100461t. Epub 2010 Oct 5. J Nat Prod. 2010. PMID: 20923180 Free PMC article.
Two new five-membered-ring polyketide endoperoxides, epiplakinic acid F methyl ester (1) and epiplakinidioic acid (3), and a peroxide-lactone, plakortolide J (2), were isolated from the Puerto Rican sponge Plakortis halichondrioides, along with two previously report …
Two new five-membered-ring polyketide endoperoxides, epiplakinic acid F methyl ester (1) and epiplakinidioic acid (3), and a peroxide-lacton …
Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association.
Dalisay DS, Quach T, Molinski TF. Dalisay DS, et al. Org Lett. 2010 Apr 2;12(7):1524-7. doi: 10.1021/ol100249v. Org Lett. 2010. PMID: 20205426 Free PMC article.
Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were isolated from a two-sponge association of Plakortis halichondroides and Xestospongia deweerdtae. The absolute configurations of the remote dimethyl-branched stereocenters in plakinic acid K were …
Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were isolated from a two-sponge association of Plakortis halich …
Glanvillic acids A and B and methyl capucinoate A, new metabolites isolated from the Caribbean sponges Plakortis halichondrioides and Plakinastrella onkodes.
Williams DE, Allen TM, Van Soest R, Behrisch HW, Andersen RJ. Williams DE, et al. J Nat Prod. 2001 Mar;64(3):281-5. doi: 10.1021/np000417i. J Nat Prod. 2001. PMID: 11277739
Glanvillic acids A (2) and B (3) and the cytotoxic cyclic peroxides methyl capucinoate A (4) and 5 were isolated from the Dominican marine sponges Plakortis halichondrioides and Plakinastrella onkodes, respectively. ...
Glanvillic acids A (2) and B (3) and the cytotoxic cyclic peroxides methyl capucinoate A (4) and 5 were isolated from the Dominican marine s …
Three new cytotoxic metabolites from the marine sponge Plakortis halichondrioides.
Rudi A, Kashman Y. Rudi A, et al. J Nat Prod. 1993 Oct;56(10):1827-30. doi: 10.1021/np50100a027. J Nat Prod. 1993. PMID: 8277322
Three new cytotoxic compounds, one a cyclic-peroxide-containing acid (5) and the two others alkylated dihydroxy alpha,beta-unsaturated C22 and C21 acids (6 and 7), were isolated from the marine sponge Plakortis halichondrioides, which was collected off the coast of …
Three new cytotoxic compounds, one a cyclic-peroxide-containing acid (5) and the two others alkylated dihydroxy alpha,beta-unsaturated C22 a …
Plakortides M and N, bioactive polyketide endoperoxides from the Caribbean marine sponge Plakortis halichondrioides.
del Sol Jiménez M, Garzón SP, Rodríguez AD. del Sol Jiménez M, et al. J Nat Prod. 2003 May;66(5):655-61. doi: 10.1021/np030021h. J Nat Prod. 2003. PMID: 12762801
From a small specimen of the marine sponge Plakortis halichondrioides collected in Puerto Rico we have isolated the known unsaturated ester methyl (2Z,6R,8R,9E)-3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate (1) along with the known cyclic peroxide plakortide F (2). …
From a small specimen of the marine sponge Plakortis halichondrioides collected in Puerto Rico we have isolated the known unsa …
16 results