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Results: 1 to 20 of 115


Structural determinants of phenotypic diversity and replication rate of human prions.

Safar JG, Xiao X, Kabir ME, Chen S, Kim C, Haldiman T, Cohen Y, Chen W, Cohen ML, Surewicz WK.

PLoS Pathog. 2015 Apr 14;11(4):e1004832. doi: 10.1371/journal.ppat.1004832. eCollection 2015 Apr.


From Neurodegeneration to Brain Health: An Integrated Approach.

Petersen RB, Lissemore FM, Appleby B, Aggarwal N, Boyatzis R, Casadesus G, Cummings J, Jack A, Perry G, Safar J, Sajatovic M, Surewicz W, Wang Y, Whitehouse P, Lerner A.

J Alzheimers Dis. 2015 Feb 26. [Epub ahead of print]


Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β.

Cohen ML, Kim C, Haldiman T, ElHag M, Mehndiratta P, Pichet T, Lissemore F, Shea M, Cohen Y, Chen W, Blevins J, Appleby BS, Surewicz K, Surewicz WK, Sajatovic M, Tatsuoka C, Zhang S, Mayo P, Butkiewicz M, Haines JL, Lerner AJ, Safar JG.

Brain. 2015 Apr;138(Pt 4):1009-22. doi: 10.1093/brain/awv006. Epub 2015 Feb 15.


Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.

Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D.

EMBO Mol Med. 2015 Feb 6;7(3):339-56. doi: 10.15252/emmm.201404588.


Structural and functional partitioning of bread wheat chromosome 3B.

Choulet F, Alberti A, Theil S, Glover N, Barbe V, Daron J, Pingault L, Sourdille P, Couloux A, Paux E, Leroy P, Mangenot S, Guilhot N, Le Gouis J, Balfourier F, Alaux M, Jamilloux V, Poulain J, Durand C, Bellec A, Gaspin C, Safar J, Dolezel J, Rogers J, Vandepoele K, Aury JM, Mayer K, Berges H, Quesneville H, Wincker P, Feuillet C.

Science. 2014 Jul 18;345(6194):1249721. doi: 10.1126/science.1249721.


Whole-genome profiling and shotgun sequencing delivers an anchored, gene-decorated, physical map assembly of bread wheat chromosome 6A.

Poursarebani N, Nussbaumer T, Simková H, Safář J, Witsenboer H, van Oeveren J, Doležel J, Mayer KF, Stein N, Schnurbusch T.

Plant J. 2014 Jul;79(2):334-47. doi: 10.1111/tpj.12550. Epub 2014 Jun 19.


Expression response of duplicated metallothionein 3 gene to copper stress in Silene vulgaris ecotypes.

Nevrtalova E, Baloun J, Hudzieczek V, Cegan R, Vyskot B, Dolezel J, Safar J, Milde D, Hobza R.

Protoplasma. 2014 Nov;251(6):1427-39. doi: 10.1007/s00709-014-0644-x. Epub 2014 Apr 20.


Prion disease tempo determined by host-dependent substrate reduction.

Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG.

J Clin Invest. 2014 Feb;124(2):847-58. doi: 10.1172/JCI72241. Epub 2014 Jan 16.


A physical map of the short arm of wheat chromosome 1A.

Breen J, Wicker T, Shatalina M, Frenkel Z, Bertin I, Philippe R, Spielmeyer W, Simková H, Safář J, Cattonaro F, Scalabrin S, Magni F, Vautrin S, Bergès H; International Wheat Genome Sequencing Consortium, Paux E, Fahima T, Doležel J, Korol A, Feuillet C, Keller B.

PLoS One. 2013 Nov 21;8(11):e80272. doi: 10.1371/journal.pone.0080272. eCollection 2013.


Flow sorting and sequencing meadow fescue chromosome 4F.

Kopecký D, Martis M, Číhalíková J, Hřibová E, Vrána J, Bartoš J, Kopecká J, Cattonaro F, Stočes Š, Novák P, Neumann P, Macas J, Šimková H, Studer B, Asp T, Baird JH, Navrátil P, Karafiátová M, Kubaláková M, Šafář J, Mayer K, Doležel J.

Plant Physiol. 2013 Nov;163(3):1323-37. doi: 10.1104/pp.113.224105. Epub 2013 Oct 4.


Can a late bloomer become an early bird? Tools for flowering time adjustment.

Milec Z, Valárik M, Bartoš J, Safář J.

Biotechnol Adv. 2014 Jan-Feb;32(1):200-14. doi: 10.1016/j.biotechadv.2013.09.008. Epub 2013 Oct 1. Review.


Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection.

Haldiman T, Kim C, Cohen Y, Chen W, Blevins J, Qing L, Cohen ML, Langeveld J, Telling GC, Kong Q, Safar JG.

J Biol Chem. 2013 Oct 11;288(41):29846-61. doi: 10.1074/jbc.M113.500108. Epub 2013 Aug 23.


A high density physical map of chromosome 1BL supports evolutionary studies, map-based cloning and sequencing in wheat.

Philippe R, Paux E, Bertin I, Sourdille P, Choulet F, Laugier C, Simková H, Safář J, Bellec A, Vautrin S, Frenkel Z, Cattonaro F, Magni F, Scalabrin S, Martis MM, Mayer KF, Korol A, Bergès H, Doležel J, Feuillet C.

Genome Biol. 2013 Jun 25;14(6):R64. doi: 10.1186/gb-2013-14-6-r64.


Physical mapping integrated with syntenic analysis to characterize the gene space of the long arm of wheat chromosome 1A.

Lucas SJ, Akpınar BA, Kantar M, Weinstein Z, Aydınoğlu F, Safář J, Simková H, Frenkel Z, Korol A, Magni F, Cattonaro F, Vautrin S, Bellec A, Bergès H, Doležel J, Budak H.

PLoS One. 2013 Apr 16;8(4):e59542. doi: 10.1371/journal.pone.0059542. Print 2013.


Intraspecific sequence comparisons reveal similar rates of non-collinear gene insertion in the B and D genomes of bread wheat.

Bartoš J, Vlček C, Choulet F, Džunková M, Cviková K, Safář J, Simková H, Pačes J, Strnad H, Sourdille P, Bergès H, Cattonaro F, Feuillet C, Doležel J.

BMC Plant Biol. 2012 Aug 30;12:155.


Chromosomes in the flow to simplify genome analysis.

Doležel J, Vrána J, Safář J, Bartoš J, Kubaláková M, Simková H.

Funct Integr Genomics. 2012 Aug;12(3):397-416. doi: 10.1007/s10142-012-0293-0. Epub 2012 Aug 16. Review.


Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

Kim C, Haldiman T, Surewicz K, Cohen Y, Chen W, Blevins J, Sy MS, Cohen M, Kong Q, Telling GC, Surewicz WK, Safar JG.

PLoS Pathog. 2012;8(8):e1002835. doi: 10.1371/journal.ppat.1002835. Epub 2012 Aug 2.


Sporadic human prion diseases: molecular insights and diagnosis.

Puoti G, Bizzi A, Forloni G, Safar JG, Tagliavini F, Gambetti P.

Lancet Neurol. 2012 Jul;11(7):618-28. doi: 10.1016/S1474-4422(12)70063-7. Review. Erratum in: Lancet Neurol. 2012 Oct;11(10):841.


Molecular pathogenesis of sporadic prion diseases in man.

Safar JG.

Prion. 2012 Apr-Jun;6(2):108-15. doi: 10.4161/pri.18666. Epub 2012 Apr 1. Review.

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