[Human pluripotent stem cells: opening key for pathological modeling].
Med Sci (Paris). 2011.
PMID: 21524412
Review.
French.
No abstract available.
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[Human pluripotent stem cells: opening key for pathological modeling].
Med Sci (Paris). 2011 Apr;27(4):443-6. doi: 10.1051/medsci/2011274023. Epub 2011 Apr 28.
Med Sci (Paris). 2011.
PMID: 21524412
Free article.
Review.
French.
No abstract available.
The potential of induced pluripotent stem cells as a tool to study skeletal dysplasias and cartilage-related pathologic conditions.
Osteoarthritis Cartilage. 2017 May;25(5):616-624. doi: 10.1016/j.joca.2016.11.015. Epub 2016 Dec 3.
Osteoarthritis Cartilage. 2017.
PMID: 27919783
Free article.
Review.
The development of induced pluripotent stem cells (iPSCs) technology has opened up new horizons for development of new research tools especially for skeletal dysplasias, which often lack human disease models. ...
The development of induced pluripotent stem cells (iPSCs) technology has opened up new horizons for development …
Patient-Derived Induced Pluripotent Stem Cells (iPSCs) and Cerebral Organoids for Drug Screening and Development in Autism Spectrum Disorder: Opportunities and Challenges.
Pharmaceutics. 2021 Feb 19;13(2):280. doi: 10.3390/pharmaceutics13020280.
Pharmaceutics. 2021.
PMID: 33669772
Free PMC article.
Review.
The clinical heterogeneity and complex etiology of this pediatric disorder have limited the development of pharmacological therapies. The major limit to ASD research remains a lack of relevant human disease models which can faithfully recapitulate key feature …
The clinical heterogeneity and complex etiology of this pediatric disorder have limited the development of pharmacological therapies. The ma …
Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?
Front Immunol. 2020 Dec 21;11:573562. doi: 10.3389/fimmu.2020.573562. eCollection 2020.
Front Immunol. 2020.
PMID: 33408713
Free PMC article.
Review.
Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes. Organoid models can be derived from induced pluripotent stem cells (iPSCs) or from primary stem cell …
Individualised cellular models of disease are a key tool for precision medicine to recapitulate chronic inflammatory processes …
Applications of Induced Pluripotent Stem Cell-Derived Glia in Brain Disease Research and Treatment.
Handb Exp Pharmacol. 2023;281:103-140. doi: 10.1007/164_2023_697.
Handb Exp Pharmacol. 2023.
PMID: 37735301
Review.
Induced pluripotent stem cell (iPSC)-derived glia provide opportunities to study the contributions of glia in human brain diseases. These cells have been used for human disease modeling as well as generating new therapies. ...
Induced pluripotent stem cell (iPSC)-derived glia provide opportunities to study the contributions of glia in human bra …
Vascularized Brain Assembloids with Enhanced Cellular Complexity Provide Insights into The Cellular Deficits of Tauopathy.
bioRxiv [Preprint]. 2023 Jul 2:2023.06.30.547293. doi: 10.1101/2023.06.30.547293.
bioRxiv. 2023.
PMID: 37425812
Free PMC article.
Updated.
Preprint.
Advanced technologies have enabled the engineering of self-organized 3-dimensional (3D) cellular structures from human induced pluripotent stem cells (hiPSCs), namely organoids, which recapitulate some key features of tissue development and func …
Advanced technologies have enabled the engineering of self-organized 3-dimensional (3D) cellular structures from human induced plu …
Amyloid precursor proteins, neural differentiation of pluripotent stem cells and its relevance to Alzheimer's disease.
Stem Cells Dev. 2012 May 1;21(7):997-1006. doi: 10.1089/scd.2011.0564. Epub 2012 Jan 18.
Stem Cells Dev. 2012.
PMID: 22122714
Review.
Indeed, the advent of induced pluripotent stem cell technology has opened up exciting new avenues for generating patient and disease-specific cell lines from somatic cells that may be used to model AD. ...Stem cell technology offers the o …
Indeed, the advent of induced pluripotent stem cell technology has opened up exciting new avenues for generating patien …
Anti-fibrotic effect of a selective estrogen receptor modulator in systemic sclerosis.
Stem Cell Res Ther. 2022 Jul 15;13(1):303. doi: 10.1186/s13287-022-02987-w.
Stem Cell Res Ther. 2022.
PMID: 35841004
Free PMC article.
BACKGROUND: The rarity of systemic sclerosis (SSc) has hampered the development of therapies for this intractable autoimmune disease. Induced pluripotent stem cell (iPSC) can be differentiated into the key disease-affected cells in vitro. The generatio …
BACKGROUND: The rarity of systemic sclerosis (SSc) has hampered the development of therapies for this intractable autoimmune disease. Induce …
Stem cell models of cardiac development and disease.
Annu Rev Cell Dev Biol. 2010;26:667-87. doi: 10.1146/annurev-cellbio-100109-103948.
Annu Rev Cell Dev Biol. 2010.
PMID: 20604707
Free PMC article.
Review.
The recent identification of cardiovascular progenitor cells, as well as the identification of genetic variants underlying congenital heart disorders and adult disease, opens the door to the development of human models of human cardiovascular di …
The recent identification of cardiovascular progenitor cells, as well as the identification of genetic variants underlying congenital …
High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission.
Anesth Analg. 2016 May;122(5):1269-79. doi: 10.1213/ANE.0000000000001254.
Anesth Analg. 2016.
PMID: 26991754
Free PMC article.
To investigate the role of glucose concentration in ROS production and mitochondrial fission during ischemia-reperfusion (with and without anesthetic protection), we used the novel platform of human-induced pluripotent stem-cell (iPSC)-derived cardiomyocytes …
To investigate the role of glucose concentration in ROS production and mitochondrial fission during ischemia-reperfusion (with and without a …
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