Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.
Quan ML, Liauw AY, Ellis CD, Pruitt JR, Carini DJ, Bostrom LL, Huang PP, Harrison K, Knabb RM, Thoolen MJ, Wong PC, Wexler RR.
Quan ML, et al.
J Med Chem. 1999 Jul 29;42(15):2752-9. doi: 10.1021/jm980405i.
J Med Chem. 1999.
PMID: 10425086
We report a series of novel biaryl-substituted isoxazoline derivatives in which the biaryl moiety was designed to interact with the S(4) aryl-binding domain of the FXa active site. Several of the compounds herein have low nanomolar affinity for FXa, have good in vitro sele …
We report a series of novel biaryl-substituted isoxazoline derivatives in which the biaryl moiety was designed to interact with the S(4 …