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Year Number of Results
2019 11
2020 17
2021 16
2022 16
2023 11
2024 1

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60 results

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Page 1
Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors.
Klein AP. Klein AP. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):493-502. doi: 10.1038/s41575-021-00457-x. Epub 2021 May 17. Nat Rev Gastroenterol Hepatol. 2021. PMID: 34002083 Free PMC article. Review.
Inherited genetic factors, although not directly modifiable, are an important component of pancreatic cancer risk, and include pathogenic variants in hereditary cancer genes, genes associated with hereditary pancreatitis, as well as common variants identified in gen …
Inherited genetic factors, although not directly modifiable, are an important component of pancreatic cancer risk, and include pathogenic va …
Diagnosis and Management of Chronic Pancreatitis: A Review.
Singh VK, Yadav D, Garg PK. Singh VK, et al. JAMA. 2019 Dec 24;322(24):2422-2434. doi: 10.1001/jama.2019.19411. JAMA. 2019. PMID: 31860051 Review.
Up to 50% of these individuals have mutations of the trypsin inhibitor gene (SPINK1) or the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Approximately 1% of people diagnosed with CP may have hereditary pancreatitis, associated with cationic tryps …
Up to 50% of these individuals have mutations of the trypsin inhibitor gene (SPINK1) or the cystic fibrosis transmembrane conductance regula …
Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.
Goggins M, Overbeek KA, Brand R, Syngal S, Del Chiaro M, Bartsch DK, Bassi C, Carrato A, Farrell J, Fishman EK, Fockens P, Gress TM, van Hooft JE, Hruban RH, Kastrinos F, Klein A, Lennon AM, Lucas A, Park W, Rustgi A, Simeone D, Stoffel E, Vasen HFA, Cahen DL, Canto MI, Bruno M; International Cancer of the Pancreas Screening (CAPS) consortium. Goggins M, et al. Gut. 2020 Jan;69(1):7-17. doi: 10.1136/gutjnl-2019-319352. Epub 2019 Oct 31. Gut. 2020. PMID: 31672839 Free PMC article.
Main areas of disagreement included if and how surveillance should be performed for hereditary pancreatitis, and the management of indeterminate lesions. ...
Main areas of disagreement included if and how surveillance should be performed for hereditary pancreatitis, and the managemen …
AGA Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals: Expert Review.
Aslanian HR, Lee JH, Canto MI. Aslanian HR, et al. Gastroenterology. 2020 Jul;159(1):358-362. doi: 10.1053/j.gastro.2020.03.088. Epub 2020 May 19. Gastroenterology. 2020. PMID: 32416142 Review.
BEST PRACTICE ADVICE 2: Pancreas cancer screening should be considered in patients with genetic syndromes associated with an increased risk of pancreas cancer, including all patients with Peutz-Jeghers syndrome, hereditary pancreatitis, patients with CDKN2A gene mut …
BEST PRACTICE ADVICE 2: Pancreas cancer screening should be considered in patients with genetic syndromes associated with an increased risk …
Genetic Evaluation of Pancreatitis.
Fu Y, Lucas AL. Fu Y, et al. Gastrointest Endosc Clin N Am. 2022 Jan;32(1):27-43. doi: 10.1016/j.giec.2021.08.006. Gastrointest Endosc Clin N Am. 2022. PMID: 34798985 Review.
Hereditary pancreatitis (HP) is a rare inherited chronic pancreatitis (CP) with strong genetic associations, with estimated prevalence ranging from 0.3 to 0.57 per 100,000 across Europe, North America, and East Asia. ...
Hereditary pancreatitis (HP) is a rare inherited chronic pancreatitis (CP) with strong genetic associations, with estimated pr …
Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
Chanda D, Thoudam T, Sinam IS, Lim CW, Kim M, Wang J, Lee KM, Ma J, Saxena R, Choi J, Oh CJ, Lee H, Jeon YH, Cho SJ, Jung HY, Park KG, Choi HS, Suh JM, Auwerx J, Ji B, Liangpunsakul S, Jeon JH, Lee IK. Chanda D, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2219644120. doi: 10.1073/pnas.2219644120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155882 Free PMC article.
Using two different mouse models of pancreatitis, we showed that pharmacological blockade of ERRgamma-VDAC1 pathway has therapeutic benefits in mitigating progression of pancreatitis. Likewise, using PRSS1(R122H)-Tg mice to mimic human hereditary pancreatitis, we de …
Using two different mouse models of pancreatitis, we showed that pharmacological blockade of ERRgamma-VDAC1 pathway has therapeutic benefits …
A New Insight into Chronic Pancreatitis.
Shimosegawa T. Shimosegawa T. Tohoku J Exp Med. 2019 Aug;248(4):225-238. doi: 10.1620/tjem.248.225. Tohoku J Exp Med. 2019. PMID: 31378749 Free article. Review.
CP has long been understood based on a fixed disease concept deduced from the clinical and morphological features of the end-stage disease. However, identification of causal genes for hereditary pancreatitis and success in the isolation and culture of pancreatic ste …
CP has long been understood based on a fixed disease concept deduced from the clinical and morphological features of the end-stage disease. …
Impact of hereditary pancreatitis on patients and their families.
Shelton CA, Grubs RE, Umapathy C, Yadav D, Whitcomb DC. Shelton CA, et al. J Genet Couns. 2020 Dec;29(6):971-982. doi: 10.1002/jgc4.1221. Epub 2020 Feb 5. J Genet Couns. 2020. PMID: 32026589 Free PMC article.
Hereditary pancreatitis (HP), a highly penetrant (~80%) autosomal dominant disease associated with PRSS1 variants, causes acute pancreatitis in childhood and chronic pancreatitis by early adulthood. ...
Hereditary pancreatitis (HP), a highly penetrant (~80%) autosomal dominant disease associated with PRSS1 variants, causes acut …
The clinical and genetic features of hereditary pancreatitis in South Australia.
Wu D, Bampton TJ, Scott HS, Brown A, Kassahn K, Drogemuller C, De Sousa SM, Moore D, Ha T, Chen JW, Khurana S, Torpy DJ, Radford T, Couper R, Palmer L, Coates PT. Wu D, et al. Med J Aust. 2022 Jun 20;216(11):578-582. doi: 10.5694/mja2.51517. Epub 2022 May 16. Med J Aust. 2022. PMID: 35578795 Free PMC article.
OBJECTIVE: To characterise the clinical phenotypes and genetic variants of hereditary pancreatitis in people diagnosed in South Australia. DESIGN, SETTING, PARTICIPANTS: Cross-sectional study of people who received molecular diagnoses of hereditary pancrea …
OBJECTIVE: To characterise the clinical phenotypes and genetic variants of hereditary pancreatitis in people diagnosed in Sout …
Transgenic Expression of PRSS1R122H Sensitizes Mice to Pancreatitis.
Huang H, Swidnicka-Siergiejko AK, Daniluk J, Gaiser S, Yao Y, Peng L, Zhang Y, Liu Y, Dong M, Zhan X, Wang H, Bi Y, Li Z, Ji B, Logsdon CD. Huang H, et al. Gastroenterology. 2020 Mar;158(4):1072-1082.e7. doi: 10.1053/j.gastro.2019.08.016. Epub 2019 Aug 13. Gastroenterology. 2020. PMID: 31419436 Free PMC article.
BACKGROUND & AIMS: Mutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. ...CONCLUSIONS: Expression of a transgene encoding PRSS1(R122H) in mice promot …
BACKGROUND & AIMS: Mutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear …
60 results