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Sclerostin and Cardiovascular Disease.
Tobias JH. Tobias JH. Curr Osteoporos Rep. 2023 Oct;21(5):519-526. doi: 10.1007/s11914-023-00810-w. Epub 2023 Jul 25. Curr Osteoporos Rep. 2023. PMID: 37490188 Free PMC article. Review.
To further examine the causal relationship between sclerostin inhibition and CVD risk, three Mendelian randomisation (MR) studies have examined effects of sclerostin lowering on CVD outcomes, using common genetic variants in the SOST gene which produces sclerostin, to mimi …
To further examine the causal relationship between sclerostin inhibition and CVD risk, three Mendelian randomisation (MR) studies have exami …
Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization.
Zheng J, Wheeler E, Pietzner M, Andlauer TFM, Yau MS, Hartley AE, Brumpton BM, Rasheed H, Kemp JP, Frysz M, Robinson J, Reppe S, Prijatelj V, Gautvik KM, Falk L, Maerz W, Gergei I, Peyser PA, Kavousi M, de Vries PS, Miller CL, Bos M, van der Laan SW, Malhotra R, Herrmann M, Scharnagl H, Kleber M, Dedoussis G, Zeggini E, Nethander M, Ohlsson C, Lorentzon M, Wareham N, Langenberg C, Holmes MV, Davey Smith G, Tobias JH. Zheng J, et al. Arthritis Rheumatol. 2023 Oct;75(10):1781-1792. doi: 10.1002/art.42538. Epub 2023 Aug 3. Arthritis Rheumatol. 2023. PMID: 37096546 Free PMC article.
RESULTS: We found that 18 conditionally independent variants were associated with circulating sclerostin. Of these, 1 cis signal in SOST and 3 trans signals in B4GALNT3, RIN3, and SERPINA1 regions showed directionally opposite signals for sclerostin levels and estimated bo …
RESULTS: We found that 18 conditionally independent variants were associated with circulating sclerostin. Of these, 1 cis signal in SOST
Epigenetic therapies of osteoporosis.
de Nigris F, Ruosi C, Colella G, Napoli C. de Nigris F, et al. Bone. 2021 Jan;142:115680. doi: 10.1016/j.bone.2020.115680. Epub 2020 Oct 6. Bone. 2021. PMID: 33031975 Review.
Bisphosphonates (BPs), target therapy blocking RANK/RANKL pathway, and anti-sclerostin antibody (SOST) are the main therapeutic approaches. However, future large trials will reveal whether epigenetic therapies of osteoporosis will remain a work in progress or data will bec …
Bisphosphonates (BPs), target therapy blocking RANK/RANKL pathway, and anti-sclerostin antibody (SOST) are the main therapeutic appro …
The Genetic Architecture of High Bone Mass.
Gregson CL, Duncan EL. Gregson CL, et al. Front Endocrinol (Lausanne). 2020 Oct 29;11:595653. doi: 10.3389/fendo.2020.595653. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33193107 Free PMC article. Review.
Genetics and Genomics of SOST: Functional Analysis of Variants and Genomic Regulation in Osteoblasts.
Martínez-Gil N, Roca-Ayats N, Cozar M, Garcia-Giralt N, Ovejero D, Nogués X, Grinberg D, Balcells S. Martínez-Gil N, et al. Int J Mol Sci. 2021 Jan 6;22(2):489. doi: 10.3390/ijms22020489. Int J Mol Sci. 2021. PMID: 33419004 Free PMC article.
SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the canonical Wnt pathway in bone, playing a crucial role in skeletal development and bone homeostasis. ...In conclusion, SOST presents functional regulatory and missense variants th
SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the canonical Wnt pathway in bone, playing a cruc
Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women.
Ciubean AD, Ungur RA, Irsay L, Ciortea VM, Borda IM, Dogaru GB, Trifa AP, Vesa SC, Buzoianu AD. Ciubean AD, et al. PLoS One. 2019 Nov 27;14(11):e0225776. doi: 10.1371/journal.pone.0225776. eCollection 2019. PLoS One. 2019. PMID: 31774873 Free PMC article.
OBJECTIVES: This study aimed to assess the relationship between bone mineral density and genotypes of four polymorphisms in previously detected osteoporosis-candidate genes (FDPS rs2297480, LRP5 rs3736228, SOST rs1234612, VKORC1 rs9934438) in postmenopausal Romanian women …
OBJECTIVES: This study aimed to assess the relationship between bone mineral density and genotypes of four polymorphisms in previously detec …
Decreased Serum Wnt Antagonist Levels in Patients With Active Acromegaly.
Chen H, Huang H, Wang Y, Zhang Y, Liu M, Lou Y, Zhang Z, Zhu D, Li P. Chen H, et al. Endocr Pract. 2022 May;28(5):515-520. doi: 10.1016/j.eprac.2022.01.011. Epub 2022 Feb 2. Endocr Pract. 2022. PMID: 35123069
Serum SOST and WIF-1 levels were negatively correlated with growth hormone levels; SOST levels were positively correlated with WIF-1. ...In biochemically controlled patients, SOST and WIF-1 levels and bone turnover markers were restored and did not differ fro …
Serum SOST and WIF-1 levels were negatively correlated with growth hormone levels; SOST levels were positively correlated with …
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5.
Diegel CR, Kramer I, Moes C, Foxa GE, McDonald MJ, Madaj ZB, Guth S, Liu J, Harris JL, Kneissel M, Williams BO. Diegel CR, et al. Bone Res. 2023 Aug 24;11(1):47. doi: 10.1038/s41413-023-00278-5. Bone Res. 2023. PMID: 37612291 Free PMC article.
We treated three different mouse models of high bone mass caused by aberrant Wnt signaling, including homozygosity for loss-of-function in Sost, which models sclerosteosis, and two strains of mice carrying different point mutations in Lrp5 (equivalent to human G171V and A2 …
We treated three different mouse models of high bone mass caused by aberrant Wnt signaling, including homozygosity for loss-of-function in …
Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses.
Kaya S, Schurman CA, Dole NS, Evans DS, Alliston T. Kaya S, et al. J Bone Miner Res. 2022 Apr;37(4):804-817. doi: 10.1002/jbmr.4516. Epub 2022 Feb 28. J Bone Miner Res. 2022. PMID: 35094432 Free PMC article.
Though these genes were not the most differentially expressed, they included Sost, Lrp5, and others with well-established functions in bone. Several others have, as yet, unknown roles in the skeleton. ...
Though these genes were not the most differentially expressed, they included Sost, Lrp5, and others with well-established functions i …
Serum sclerostin levels in osteoporotic fracture patients.
Gorter EA, Reinders CR, Krijnen P, Appelman-Dijkstra NM, Schipper IB. Gorter EA, et al. Eur J Trauma Emerg Surg. 2022 Dec;48(6):4857-4865. doi: 10.1007/s00068-022-02017-7. Epub 2022 Jun 16. Eur J Trauma Emerg Surg. 2022. PMID: 35705746 Free PMC article.
After defrosting biobank samples, serum sclerostin was measured using the human SOST (sclerostin) enzyme-linked immunosorbent assay kit. We prespecified a subgroup analysis including only female patients. ...
After defrosting biobank samples, serum sclerostin was measured using the human SOST (sclerostin) enzyme-linked immunosorbent assay k …
57 results