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Year Number of Results
2019 3
2020 17
2021 9
2022 3
2023 4
2024 0

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Page 1
Small Heat Shock Proteins and Human Neurodegenerative Diseases.
Muranova LK, Ryzhavskaya AS, Sudnitsyna MV, Shatov VM, Gusev NB. Muranova LK, et al. Biochemistry (Mosc). 2019 Nov;84(11):1256-1267. doi: 10.1134/S000629791911004X. Biochemistry (Mosc). 2019. PMID: 31760916 Free article. Review.
The effects of CMT-associated mutations in two small heat shock proteins (HspB1 and HspB8) on the protein stability, oligomeric structure, and chaperone-like activity are described. Mutations in HspB1 shift the equilibrium between different protein oligomeric forms, leadin …
The effects of CMT-associated mutations in two small heat shock proteins (HspB1 and HspB8) on the protein stability, oligomeric struc …
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas.
Zhao S, Li J, Zhang H, Qi L, Du Y, Kogiso M, Braun FK, Xiao S, Huang Y, Li J, Teo WY, Lindsay H, Baxter P, Su JMF, Adesina A, Laczik M, Genevini P, Veillard AC, Schvartzman S, Berguet G, Ding SR, Du L, Stephan C, Yang J, Davies PJA, Lu X, Chintagumpala M, Parsons DW, Perlaky L, Xia YF, Man TK, Huang Y, Sun D, Li XN. Zhao S, et al. Nat Commun. 2022 Nov 5;13(1):6689. doi: 10.1038/s41467-022-34514-z. Nat Commun. 2022. PMID: 36335125 Free PMC article.
Integrating with RNAseq reveals differentially expressed genes regulated by potential driver DMRs (CACNA1H, SLC12A7, RARA in RELA and HSPB8, GMPR, ITGB4 in PFA) and potential booster DMRs (PLEKHG1 in RELA and NOTCH, EPHA2, SUFU, FOXJ1 in PFA tumors). ...
Integrating with RNAseq reveals differentially expressed genes regulated by potential driver DMRs (CACNA1H, SLC12A7, RARA in RELA and HSP …
Small heat shock proteins in neurodegenerative diseases.
Vendredy L, Adriaenssens E, Timmerman V. Vendredy L, et al. Cell Stress Chaperones. 2020 Jul;25(4):679-699. doi: 10.1007/s12192-020-01101-4. Epub 2020 Apr 22. Cell Stress Chaperones. 2020. PMID: 32323160 Free PMC article. Review.
The first half of this paper will be focused on how mutations in HSPB1, HSPB3, and HSPB8 are linked to inherited peripheral neuropathies like Charcot-Marie-Tooth (CMT) disease and distal hereditary motor neuropathy (dHMN). ...
The first half of this paper will be focused on how mutations in HSPB1, HSPB3, and HSPB8 are linked to inherited peripheral neuropath …
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE. Abdel-Nour M, et al. Science. 2019 Jul 5;365(6448):eaaw4144. doi: 10.1126/science.aaw4144. Science. 2019. PMID: 31273097 Free PMC article.
We found that the eIF2alpha kinase heme-regulated inhibitor (HRI) controls NOD1 signalosome folding and activation through a process requiring eukaryotic initiation factor 2alpha (eIF2alpha), the transcription factor ATF4, and the heat shock protein HSPB8. The HRI/eIF2alph …
We found that the eIF2alpha kinase heme-regulated inhibitor (HRI) controls NOD1 signalosome folding and activation through a process requiri …
HSPB8 promoted intrahepatic cholangiocarcinoma progression by enhancing epithelial-mesenchymal transition and autophagy.
Shu B, Zhou Y, Liang Q, He C, Li F. Shu B, et al. Exp Mol Pathol. 2021 Dec;123:104691. doi: 10.1016/j.yexmp.2021.104691. Epub 2021 Oct 1. Exp Mol Pathol. 2021. PMID: 34606781 Free article.

High HSPB8 expression in ICC indicated poor prognosis of patients. HSPB8 expression was mainly expressed in cell cytoplasm and aberrantly increased in RBE cells (P < 0.01). ...CONCLUSION: HSPB8 promoted ICC progression by enhancing EMT and autophagy. HS

…
High HSPB8 expression in ICC indicated poor prognosis of patients. HSPB8 expression was mainly expressed in cell cytoplasm and …
PINK1 and Parkin rescue motor defects and mitochondria dysfunction induced by a patient-derived HSPB3 mutant in Drosophila models.
Han JE, Kang KH, Kim H, Hong YB, Choi BO, Koh H. Han JE, et al. Biochem Biophys Res Commun. 2023 Nov 19;682:71-76. doi: 10.1016/j.bbrc.2023.09.092. Epub 2023 Sep 29. Biochem Biophys Res Commun. 2023. PMID: 37804589
Small heat shock proteins (sHSPs) are ATP-independent molecular chaperones with the alpha-crystalline domain that is critical to their chaperone activity. Within the sHSP family, three (HSPB1, HSPB3, and HSPB8) proteins are linked with inherited peripheral neuropathies, in …
Small heat shock proteins (sHSPs) are ATP-independent molecular chaperones with the alpha-crystalline domain that is critical to their chape …
Human HspB1, HspB3, HspB5 and HspB8: Shaping these disease factors during vertebrate evolution.
Benndorf R, Velazquez R, Zehr JD, Pond SLK, Martin JL, Lucaci AG. Benndorf R, et al. Cell Stress Chaperones. 2022 Jul;27(4):309-323. doi: 10.1007/s12192-022-01268-y. Epub 2022 Jun 9. Cell Stress Chaperones. 2022. PMID: 35678958 Free PMC article.
Small heat shock proteins (sHSPs) emerged early in evolution and occur in all domains of life and nearly in all species, including humans. Mutations in four sHSPs (HspB1, HspB3, HspB5, HspB8) are associated with neuromuscular disorders. The aim of this study is to investig …
Small heat shock proteins (sHSPs) emerged early in evolution and occur in all domains of life and nearly in all species, including humans. M …
Neuromuscular Diseases Due to Chaperone Mutations: A Review and Some New Results.
Sarparanta J, Jonson PH, Kawan S, Udd B. Sarparanta J, et al. Int J Mol Sci. 2020 Feb 19;21(4):1409. doi: 10.3390/ijms21041409. Int J Mol Sci. 2020. PMID: 32093037 Free PMC article. Review.
In this review, we cover mutations in DNAJB6, DNAJB2, alphaB-crystallin (CRYAB, HSPB5), HSPB1, HSPB3, HSPB8, and BAG3, and discuss the molecular mechanisms by which they cause neuromuscular disease. ...
In this review, we cover mutations in DNAJB6, DNAJB2, alphaB-crystallin (CRYAB, HSPB5), HSPB1, HSPB3, HSPB8, and BAG3, and discuss th …
The Homeobox gene, HOXB13, Regulates a Mitotic Protein-Kinase Interaction Network in Metastatic Prostate Cancers.
Yao J, Chen Y, Nguyen DT, Thompson ZJ, Eroshkin AM, Nerlakanti N, Patel AK, Agarwal N, Teer JK, Dhillon J, Coppola D, Zhang J, Perera R, Kim Y, Mahajan K. Yao J, et al. Sci Rep. 2019 Jul 4;9(1):9715. doi: 10.1038/s41598-019-46064-4. Sci Rep. 2019. PMID: 31273254 Free PMC article.
HSPB8 mRNA expression was significantly increased following HOXB13 depletion in multiple metastatic CRPC models. Increased expression of HSPB8 by the microtubule inhibitor Colchicine or by exogenous means suppressed migration of mCRPC cells. ...
HSPB8 mRNA expression was significantly increased following HOXB13 depletion in multiple metastatic CRPC models. Increased expression …
Macrophage-specific autophagy-related gene HSPB8 is involved in the macrophage polarization in atherosclerosis.
Wang J, Zhao C, Zhang B, Liu X. Wang J, et al. BMC Cardiovasc Disord. 2023 Mar 18;23(1):141. doi: 10.1186/s12872-023-03158-2. BMC Cardiovasc Disord. 2023. PMID: 36934244 Free PMC article.
Furthermore, the expression of HSPB8 was negatively correlated with most inflammatory factors. CONCLUSION: The downregulation of MARG HSPB8 probably involves in the M2 macrophage polarization in AS samples. HSPB8 is a promising diagnostic marker for AS patien …
Furthermore, the expression of HSPB8 was negatively correlated with most inflammatory factors. CONCLUSION: The downregulation of MARG …
34 results